High speed cell assembly using microfluidics

2015 Fiscal Year Final Research Report

• Project Area: Hyper Bio Assembler for 3D Celluler Innovation
• Project/Area Number: 23106007
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Chiba University
• Principal Investigator: Seki Minoru 千葉大学, 工学(系)研究科(研究院), 教授 (80206622)
• Co-Investigator(Kenkyū-buntansha): YAMADA MASUMI 千葉大学, 大学院工学研究科, 准教授 (30546784)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: マイクロシステム / マイクロ流体デバイス / 生体組織工学 / ハイドロゲル / 細胞培養 / 生体外マトリックス / 肝細胞工学 / 細胞分離

Outline of Final Research Achievements

We have developed new technologies to produce anisotropic, complex hydrogel materials that encapsulate multiple types of cells with micrometer-scale precision, using microfluidics. We tried to build up relatively large-sized perfusable tissue models, especially liver tissues, by using unit hydrogel structures as building blocks. In addition, relating technologies such as cell sorting and transformation of ECM components into micrometer-sized particles/fibers have been developed, in order to establish versatile strategies useful for 3D tissue engineering.

Free Research Field

生物化学工学