Construction of nano-plasma control technique and biological function control by localized plasma irradiation

2016 Fiscal Year Final Research Report

• Project Area: Plasma medical innovation
• Project/Area Number: 24108004
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Tohoku University
• Principal Investigator: KANEKO Toshiro 東北大学, 工学研究科, 教授 (30312599)
• Co-Investigator(Kenkyū-buntansha): 佐藤 岳彦 東北大学, 流体科学研究所, 教授 (10302225) ; 加藤 俊顕 東北大学, 工学(系)研究科(研究院), 講師 (20502082)
• Research Collaborator: KANZAKI Makoto 東北大学, 大学院医工学研究科, 准教授 ; TACHIKAWA Masanori 東北大学, 大学院薬学研究科, 准教授 ; KANETAKA Hiroyasu 東北大学, 大学院歯学研究科, 准教授 ; TAKASHIMA Keisuke 東北大学, 大学院工学研究科, 助教
• Project Period (FY): 2012-06-28 – 2017-03-31
• Keywords: ナノプラズマ / 短寿命活性種 / 遺伝子導入 / 生体機能制御 / 局所プラズマ照射

Outline of Final Research Achievements

In order to develop a highly efficient and minimally invasive drug delivery method, the applications of plasmas generated in liquid to control of biological response have been proposed. In the beginning, it has been experimentally verified that micro-scale plasma was generated by applying a pulse voltage to coaxial type thin electrode and had the capability to enhance the cellular uptake of drugs and genes. Next, investigation of effects of separated plasma-derived stimuli on drug uptake showed that plasma-produced short-lived reactive species contribute to the drug uptake. Furthermore, it is clarified that relatively short-lived reactive species (i.e., deactivated within approximately 10 min) in plasma-irradiated saline induced physiologically relevant calcium ion influx through ion channel on cell membrane, which triggers activation of gene and drug uptake.

Free Research Field

プラズマエレクトロニクス