Elucidation of interactive mechanism on wound healing process after low temperature plasma treatment

2016 Fiscal Year Annual Research Report

• Project Area: Plasma medical innovation
• Project/Area Number: 24108006
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: 池原 譲 国立研究開発法人産業技術総合研究所, 創薬基盤研究部門, 上級主任研究員 (10311440)
• Co-Investigator(Kenkyū-buntansha): 榊田 創 国立研究開発法人産業技術総合研究所, 電子光技術研究部門, グループ長 (90357088) ; 金 載浩 国立研究開発法人産業技術総合研究所, 電子光技術研究部門, 主任研究員 (30376595) ; 中西 速夫 愛知県がんセンター(研究所), 遺伝子病理診断部, 研究員 (20207830)
• Project Period (FY): 2012-06-28 – 2017-03-31
• Keywords: 病理解析 / プラズマ解析 / タンパク凝集 / 低侵襲止血

Outline of Annual Research Achievements

本研究の目的は、申請者らが開発を進めてきた医療用プラズマ発生装置の使用で明確となる「低侵襲性」や「血液凝固やその後の創傷治癒効果」について、その作用原理・メカニズムを明らかにすることである。平成27年度までに実施した1）プラズマが作用する生体分子ネットワークの探索 (担当：池原、中西)と、2）プラズマによるタンパク凝集・分散の解析(榊田、金、池原）は、いずれも当初の予定どおりの進捗を達成してきた。これを踏まえ、プラズマによる生体分子の凝集・分散メカニズムについて構築した学理の発信に努めるとともに、その応用展開として、プラズマ照射による3) タンパク質の機能改変や形状加工を中心とした医薬品製造プロセス等における利用可能性にむけた道筋を探索した。
1）では領域横断的な体制を構築し、プラズマによる血液凝固と止血についての有効性と安全性検証を実施した。2）では試験環境の制御下に質の異なるプラズマを照射し、その影響について検討した。具体的な解析方法としては、化学プローブ法、吸収分光法、電子スピン共鳴法を用いた。質の異なるプラズマがどのように反応したかを構造変化として捉えるため、ラマン分光顕微鏡での観察により検出評価するシステムを整えて、得られた結果の理論化をすすめた。さらに3) では、医療技術への利用展開として、プラズマを起因としてタンパク質に作用する気相・界面・液中の反応プロセスについての体系的理解を進めることができた。
以上の結果、プラズマによる血液凝固の現象は、そのメカニズム理解を深めることとなり、一般のタンパク質を対象とした凝集制御技術として医薬品製造の新しいプロセスの可能性を明らかにしたと結論する。なお、域内に構築を進めた複数のワーキンググループは、参加研究者のつながりと共同研究の活性化に反映されるなどすることで、当研究計画の目標を達成したと結論する。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Consorzio RFX(イタリア)
  • Country Name: ITALY
  • Counterpart Institution: Consorzio RFX
• [Journal Article] Low temperature plasma equipment applied on surgical hemostasis and wound healings. (2017)
  • Author(s): K. Miyamoto, S. Ikehara, H. Sakakida, Y. Ikehara
  • Journal Title: J Clin Biochem Nutr. Volume: 60(1) Pages: 25-28
  • DOI: 10.3164/jcbn.16-60.
  • Peer Reviewed
• [Journal Article] Time Evolution Measurements of Emission Propagation Phenomena in Low Energy Atmospheric Pressure Plasma Using High Speed Camera, (2017)
  • Author(s): H. Yamada, H Sakakita, Y. Fujiwara, M. Fujiwara, J. Kim, H. Itagaki, S. Kato, T. Hotta, S. Kiyama, S. Ikehara, N. Shimizu, H. Nakanishi, Y. Ikehara
  • Journal Title: Proc. The 1st International Conference on Plasma Medical Science Innovation Volume: - Pages: 66
• [Journal Article] Time Evolution Measurements of Metastable Helium Atoms in a Low Energy Atmospheric Pressure Plasma Using a Laser Absorption Spectroscopic Measurement (2017)
  • Author(s): H. Sakakita, T. Hotta, A. Nonaka, H. Yamada, A. Okamoto, S. Kitajima, M. Fujiwara, S. Kato, H. Itagaki, Y. Ikehara
  • Journal Title: Proc. 1st International Conference on Plasma Medical Science Innovation Volume: - Pages: 67
• [Journal Article] Recent progress in microwave plasma sources and their applications (2017)
  • Author(s): J Kim, H. Itagaki, H. Sakakita
  • Journal Title: Proceedings of IUVSTA Workshop Volume: - Pages: -
• [Journal Article] A Low power nitriding technique utilizing a microwave excited radical flow (2016)
  • Author(s): H. Itagaki, S. Hirose, J. Kim, M. Ogura, X. Wang, A. Nonaka, H. Ogiso, H. Sakakita
  • Journal Title: Japanese Journal of Applied Physics Volume: 55-6S2 Pages: 1-5
  • DOI: 10.7567/JJAP.55.06HC05
  • Peer Reviewed
• [Journal Article] Spectroscopy of reactive species produced by low-energy atmospheric-pressure plasma on conductive target material surface (2016)
  • Author(s): H. Yamada, H. Sakakita, S. Kato, J. Kim, S. Kiyama, M, Fujiwara, H. Itagaki, T. Okazaki, S. Ikehara, H. Nakanishi, N. Shimizu, Y. Ikehara
  • Journal Title: Journal of Physics D, Applied Physics Volume: 49-394001 Pages: 1-11
  • DOI: 10.1088/0022-3727/49/39/394001
  • Peer Reviewed
• [Journal Article] Lectin microarray technology identifies specific lectins related to lymph node metastasis of advanced gastric cancer (2016)
  • Author(s): K. Yamashita, A. Kuno, A. Matsuda, Y. Ikehara, N. Katada, J. Hirabayashi, H. Narimatsu, M. Watanabe
  • Journal Title: Gastric Cancer Volume: 19(2) Pages: 531-542
  • DOI: 10.1007/s10120-015-0491-2
  • Peer Reviewed
• [Journal Article] Verification of WFA-Sialylated MUC1 as a Sensitive Biliary Biomarker for Human Biliary Tract Cancer (2016)
  • Author(s): T. Yamaguchi, Y. Yokoyama, T. Ebata, A. Matsuda, A. Kuno, Y. Ikehara, J. Shoda, H. Narimatsu, M. Nagino
  • Journal Title: Ann Surg Oncol Volume: 23(2) Pages: 671-677
  • DOI: 10.1245/s10434-015-4878-4
  • Peer Reviewed
• [Journal Article] Galectin expression in healing wounded skin treated with low-temperature plasma: Comparison with treatment by electronical coagulation (2016)
  • Author(s): Y. Akimoto, S. Ikehara, T. Yamaguchi, J. Kim, H. Kawakami, N. Shimizu, M. Hori, H. Sakakita, Y. Ikehara
  • Journal Title: Archives of Biochemistry and Biophysics Volume: 605 Pages: 86-94
  • DOI: 10.1016/j.abb.2016.01.012
  • Peer Reviewed
• [Journal Article] Red Blood Cell Coagulation Induced by Low-temperature Plasma Treatment (2016)
  • Author(s): K. Miyamoto, S. Ikehara, H. Takei, Y. Akimoto, H. Sakakida, K. Ishikawa, M. Ueda, J. Ikeda, M. Yamagishi, J. Kim, T. Yamaguchi, H. Nakanishi, N. Shimizu, M. Hori, Y. Ikehara
  • Journal Title: Archives of Biochemistry and Biophysics Volume: 605 Pages: 95-101
  • DOI: 10.1016/j.abb.2016.03.023
  • Peer Reviewed
• [Journal Article] Evaluation of fluorescence imaging with indocyanine green in hepatocellular carcinoma (2016)
  • Author(s): M. Kaibori, K. Matsui, M. Ishizaki, H. Iida, T. Sakaguchi, T. Tsuda, T. Okumura, K. Inoue, S. Shimada, S. Ohtsubo, M. Kusano, Y. Ikehara, E. Ozeki, T. Kitawaki and M. Kon
  • Journal Title: Cancer Imaging Volume: 16:6 Pages: 1-7
  • DOI: 10.1186/s40644-016-0064-6
  • Peer Reviewed
• [Journal Article] Formation of fibroblastic reticular network in the brain after infection with neurovirulent murine coronavirus (2016)
  • Author(s): R. Watanabe, M. Kakizaki, Y. Ikehara, A. Togayachi
  • Journal Title: Neuropathology Volume: 36（6） Pages: 513-526
  • DOI: 10.1111/neup.12302
  • Peer Reviewed
• [Journal Article] Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation, (2016)
  • Author(s): K. Hayashizaki, M Y. Kimura, K. Tokoyoda, H. Hosokawa, K. Shinoda, K. Hirahara, T. Ichikawa, A. Onodera, A. Hanazawa, C. Iwamura, J.Kakuta, K. Muramoto, S. Motohashi, D J. Tumes, T. Iinuma, H. Yamamoto, Y. Ikehara, Y. Okamoto, and T. Nakayama,
  • Journal Title: Sci. Immunol Volume: 1（3） Pages: 9154
  • Peer Reviewed
• [Journal Article] Ex vivo culture of circulating tumor cells using magnetic force-based coculture on a fibroblast feeder layer (2016)
  • Author(s): S. Yamamoto, K . Shimizu, J. Fei, H. Iwata, M. Okochi, H. Nakanishi, H. Honda
  • Journal Title: Biotechnol J Volume: 11(11) Pages: 1433-1442
  • DOI: 10.1002/biot.201600084
  • Peer Reviewed
• [Journal Article] Modeling mesothelioma utilizing human mesothelial cells reveals involvement of phospholipase-C beta 4 in YAP-active mesothelioma cell proliferation (2016)
  • Author(s): T. Kakiuchi, T. Takahara, Y. Kasugai, K. Arita, N. Yoshida, K. Karube, M. Suguro, K. Matsuo, H. Nakanishi, T. Kiyono, S. Nakamura, H. Osada, Y. Sekido, M. Seto, S.Tsuzuki
  • Journal Title: Carcinogenesis Volume: - Pages: -
  • DOI: 10.1093/carcin/bgw084
  • Peer Reviewed
• [Journal Article] Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer (2016)
  • Author(s): H. Suzuki, M. Nishio, H. Nakanishi, N. Hanai, H. Hirakawa, T. Kodaira, T. Tamaki, Y. Hasegawa
  • Journal Title: Oncol Lett Volume: 12(2) Pages: 1493-1500
  • DOI: 10.3892/ol.2016.4765
  • Peer Reviewed
• [Journal Article] 高度物理刺激と生体応答(9)：第５章プラズマ刺激による細胞応答と応用 その３, 5.7 低侵襲プラズマ止血機器の開発 (2016)
  • Author(s): 榊田 創, 池原 譲, 清水 伸幸, 山田 大将
  • Journal Title: 機械の研究 Volume: 68 (4) Pages: 319-321
  • Peer Reviewed
• [Journal Article] 低温プラズマ技術を取り入れた低侵襲な手術用止血装置. (2016)
  • Author(s): 宮本 健司, 池原 早苗, 榊田 創, 池原 譲
  • Journal Title: 応用物理 Volume: 85(9) Pages: 793-796
  • Peer Reviewed
• [Journal Article] Catastrophic hypothesisによる膵発癌 -ヒト膵癌とマウスモデル膵癌 (2016)
  • Author(s): 山口 高志, 池原 早苗, 池原 譲
  • Journal Title: 臨床消化器内科 Volume: 31(13) Pages: (5-1).
  • Peer Reviewed
• [Journal Article] Microwave excited plasma sources using microstrip line (2016)
  • Author(s): J. Kim, H. Sakakita, H. Itagaki
  • Journal Title: Proc. 20th International Vacuum Congress Volume: - Pages: -
• [Journal Article] Time resolved behavior of metastable helium atoms in a low energy atmospheric pressure plasma using a laser absorption spectroscopic measurement (2016)
  • Author(s): T. Hotta, A. Nonaka, H. Yamada, A. Okamoto, S. Kitajima, S. Kato, M. Fujiwara, H. Itagaki, H. Sakakita
  • Journal Title: Proc. 20th International Vacuum Congress Volume: - Pages: -
• [Journal Article] Characteristic Measurements of a Low Energy Atmospheric Pressure Plasma for blood coagulation (2016)
  • Author(s): H. Yamada, H Sakakita, Y. Fujiwara, T. Hotta, J. Kim, H. Itagaki, M. Fujiwara, S. Kato, S. Kiyama, N. Shimizu, H. Nakanishi, Y. Ikehara
  • Journal Title: Proc. 20th International Vacuum Congress Volume: - Pages: -
• [Journal Article] Advanced microwave plasma technology for materials processing (2016)
  • Author(s): J. Kim, H. Itagaki, H. Sakakita
  • Journal Title: Proceedings of ICMAP2016 Volume: - Pages: -
• [Journal Article] Discharge properties of a microwave-excited atmospheric-pressure air plasma (2016)
  • Author(s): J. Kim, H. Sakakita
  • Journal Title: Proceedings of MRS-J Volume: - Pages: -
• [Journal Article] Surface wave excited plasma CVD technologies for the synthesis of carbon nanomaterials (2016)
  • Author(s): J. Kim
  • Journal Title: Vacuum Magazine Volume: 2(4) Pages: 16-26
  • DOI: 10.5757/vacmac.2.4.16
• [Journal Article] Effects of a Dielectric Material in an Ion Source on the Ion Beam Current Density and Ion Beam Energy (2016)
  • Author(s): Y. Fujiwara, H. Sakakita, A. Nakamiya, Y. Hirano, S.Kiyama
  • Journal Title: Review of Scientific Instruments Volume: 87(2) Pages: 1-3
  • DOI: 10.1063/1.4935643
• [Journal Article] 高速度カメラによる低エネルギー大気圧プラズマフレアーの時間発展計測 (2016)
  • Author(s): 山田大将、榊田創、藤原大、藤原正純、加藤進、板垣宏知、堀田朋敬、中西博之、金載浩、池原早苗、中西速夫、清水伸幸、池原譲
  • Journal Title: 第33回プラズマ・核融合学会年会予稿集 Volume: 01a Pages: 6
• [Journal Article] 医療機器等に関する開発ガイドライン策定事業「低侵襲プラズマ止血装置開発ガイドラインの教育講演」 (2016)
  • Author(s): 榊田 創
  • Journal Title: 第８回プラズマ医療・健康産業シンポジウム講演集 Volume: - Pages: 4-11
• [Journal Article] 低温プラズマが拓く生体分子、組織・細胞の加工とプロセス科学 (2016)
  • Author(s): 池原 譲
  • Journal Title: 第８回プラズマ医療・健康産業シンポジウム講演集 Volume: - Pages: 48-52
• [Journal Article] 外科手術用低侵襲プラズマ止血装置 (2016)
  • Author(s): 榊田 創、池原 譲
  • Journal Title: 医療機器開発ガイドライン総合解説 Volume: - Pages: 251-266
• [Journal Article] 低侵襲プラズマ止血装置の開発・実用化と国際標準化 (2016)
  • Author(s): 榊田 創、池原 譲
  • Journal Title: 第6回電子光技術シンポジウム「光技術の医療・ヘルスケアへの展開」 講演集 Volume: - Pages: 35-38
• [Journal Article] 近赤外レーザー吸収分光法を用いた大気圧プラズマフレアー中のヘリウム準安定原子密度の高時空間分解計測 (2016)
  • Author(s): 堀田朋敬、山田大将、野中淳司、岡本敦、北島純男、藤原正純、加藤進、板垣宏知、榊田創
  • Journal Title: 第64回応用物理学会春季学術講演会予稿集 Volume: - Pages: 15a-301-4
• [Presentation] Development of a new near infrared imaging technology over 1000nm wavelength. (2017)
  • Author(s): Y. Ikehara
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松（静岡県・浜松市）
  • Year and Date: 2017-03-28 – 2017-03-28
  • Invited
• [Presentation] 産業技術総合研究所・電子光技術研究部門における先進プラズマプロセス研究 (2017)
  • Author(s): 榊田 創
  • Organizer: Final Detonation－Aerospace Workshop in Aoyama 2017
  • Place of Presentation: 青山学院大学(東京都・渋谷区）
  • Year and Date: 2017-03-18 – 2017-03-18
  • Int'l Joint Research
• [Presentation] 近赤外レーザー吸収分光法を用いた大気圧プラズマフレアー中のヘリウム準安定原子密度の高時空間分解計測 (2017)
  • Author(s): 堀田 朋敬、山田 大将、野中 淳司、岡本敦、北島純男、藤原 正純、加藤 進、板垣 宏知、榊田 創
  • Organizer: 第64回応用物理学会春季学術講演会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市）
  • Year and Date: 2017-03-15 – 2017-03-15
• [Presentation] Recent progress in microwave plasma sources and their applications, (2017)
  • Author(s): J. Kim, H. Itagaki, H. Sakakita
  • Organizer: 81st IUVSTA Workshop on Response of Biological materials to Plasma Treated Medium
  • Place of Presentation: Rogla (Slovenia)
  • Year and Date: 2017-03-13 – 2017-03-13
  • Int'l Joint Research
• [Presentation] 病理工学連携研究による超1000nm近赤外波長域イメージング技術の開発と医用展開 (2017)
  • Author(s): 池原 譲
  • Organizer: 「大阪大学 大学院工学研究科・産総研合同シンポジウム」工学研究科 材料系/アトミックデザイン研究センター・産総研共同研究シンポジウム
  • Place of Presentation: 大阪大学（大阪府・吹田市）
  • Year and Date: 2017-03-03 – 2017-03-03
  • Invited
• [Presentation] A new therapeutic modality with Plasma-Activated Medium targeting peritoneal micrometastasis in human gastric cancer. (2017)
  • Author(s): H. Nakanishi
  • Organizer: Keynote Lecture. ISPlasma2017
  • Place of Presentation: 中部大学（愛知県・春日井市）
  • Year and Date: 2017-03-02 – 2017-03-02
  • Int'l Joint Research / Invited
• [Presentation] Time Evolution Measurements of Emission Propagation Phenomena in Low Energy Atmospheric Pressure Plasma Using High Speed Camera (2017)
  • Author(s): H. Yamada, H Sakakita, Y. Fujiwara, M. Fujiwara, J. Kim, H. Itagaki, S. Kato, T. Hotta, S. Kiyama, S. Ikehara, N. Shimizu, H. Nakanishi, Y. Ikehara19.H. Yamada, H Sakakita, Y. Fujiwara, M. Fujiwara, J. Kim, H. Itagaki, S. Kato, T. Hotta, S. Kiyama, S. Ikehara, N. Shimizu, H. Nakanishi, Y. Ikehara
  • Organizer: International Conference on Plasma Medical Science Innovation
  • Place of Presentation: 名古屋大学(愛知県・名古屋市）
  • Year and Date: 2017-02-27 – 2017-02-27
  • Int'l Joint Research
• [Presentation] Time Evolution Measurements of Metastable Helium Atoms in a Low Energy Atmospheric Pressure Plasma Using a Laser Absorption Spectroscopic Measurement (2017)
  • Author(s): H. Sakakita, T. Hotta, A. Nonaka, H. Yamada, A. Okamoto, S. Kitajima, M. Fujiwara, S. Kato, H. Itagaki, Y. Ikehar
  • Organizer: International Conference on Plasma Medical Science Innovation
  • Place of Presentation: 名古屋大学(愛知県・名古屋市）
  • Year and Date: 2017-02-27 – 2017-02-27
  • Int'l Joint Research
• [Presentation] 低侵襲プラズマ止血装置の開発・実用化と国際標準化 (2017)
  • Author(s): 榊田 創、池原 譲
  • Organizer: 第6回電子光技術シンポジウム「光技術の医療・ヘルスケアへの展開」
  • Place of Presentation: UDX カンファレンス(東京都・千代田区）
  • Year and Date: 2017-02-27 – 2017-02-27
• [Presentation] 医療機器等に関する開発ガイドライン策定事業「低侵襲プラズマ止血装置開発ガイドラインの教育講演」 (2016)
  • Author(s): 榊田 創
  • Organizer: 第８回プラズマ医療・健康産業シンポジウム
  • Place of Presentation: 産総研臨海センター（東京都・江東区）
  • Year and Date: 2016-12-22 – 2016-12-22
• [Presentation] 低温プラズマが拓く生体分子、組織・細胞の加工とプロセス科学 (2016)
  • Author(s): 池原 譲
  • Organizer: 第８回プラズマ医療・健康産業シンポジウム
  • Place of Presentation: 産総研臨海センター（東京都・江東区）
  • Year and Date: 2016-12-22 – 2016-12-22
• [Presentation] Discharge properties of a microwave-excited atmospheric-pressure air plasma (2016)
  • Author(s): J..Kim, H. Sakakita
  • Organizer: 26th Annual Meeting of MRS-J
  • Place of Presentation: Yokohama Port Opening Plaza（神奈川県・横浜市）
  • Year and Date: 2016-12-19 – 2016-12-19
  • Int'l Joint Research
• [Presentation] 高速度カメラによる低エネルギー大気圧プラズマフレアーの時間発展計測 (2016)
  • Author(s): 山田 大将、榊田 創、藤原 大、藤原 正純、加藤 進、板垣 宏知、堀田 朋敬、中西 博之、金 載浩、池原 早苗、中西速夫、清水伸幸、池原 譲
  • Organizer: 第33回プラズマ・核融合学会年会
  • Place of Presentation: 東北大学（宮城県・仙台市）
  • Year and Date: 2016-12-01 – 2016-12-01
• [Presentation] Understanding to develop treatments for pancreatic cancer using cutting-edge technologies of disease models, hemostasis with cold atmospheric plasma, and spectrophotometric imaging in over-1000nm near infrared (2016)
  • Author(s): Y. Ikehara, S. Ikehara, H. Sakakita, K. Ishikawa, T. Yamaguchi, H. Nakanishi, M. Hori
  • Organizer: 10th Anniversary International Symposium on Nanomedicine (ISNM2016)
  • Place of Presentation: 産総研(茨城県・つくば市）
  • Year and Date: 2016-11-25 – 2016-11-25
  • Int'l Joint Research / Invited
• [Presentation] Development and analysis of genetically engineered mouse models to increase knowledge for catastrophic phenotype of PDAC. (2016)
  • Author(s): T. Yamaguchi, S. K. Ikehara, N. Hayao, Y.Ikehara
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-10-07 – 2016-10-07
  • Invited
• [Presentation] Biomarker research based on the principles of pathology- Glycoproteomics using genetically engineered mouse models. (2016)
  • Author(s): Y. Ikehara
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市）
  • Year and Date: 2016-10-06 – 2016-10-06
  • Invited
• [Presentation] Advanced microwave plasma technology for materials processing (2016)
  • Author(s): J. Kim, H. Sakakita, H. Itagaki
  • Organizer: The 6th International Conference on Microelectronics and Plasma Technology (ICMAP 2016)
  • Place of Presentation: Dream Center, Gyeongju（Korea）
  • Year and Date: 2016-09-27 – 2016-09-27
  • Int'l Joint Research / Invited
• [Presentation] The interaction among plasma and proteins for hemostasis (2016)
  • Author(s): Y. Ikehara,S. Ikehara,Y. Akimoto, H. Sakakita, K. Ishikawa, M. Ueda, J. Ikeda, J. Kim, T. Yamaguchi, H. Nakanishi, T. Shimizu , N. Shimizu, M. Hori
  • Organizer: Workshop for Current concept for LTP at atmospheric pressure in medical practice
  • Place of Presentation: Gate Garchinger Technologie, Garching (Germany)
  • Year and Date: 2016-09-12 – 2016-09-12
  • Int'l Joint Research / Invited
• [Presentation] Recent advances in standardization for Plasma coagulation equipment (2016)
  • Author(s): H. Sakakita
  • Organizer: Workshop for Current concept for LTP at atmospheric pressure in medical practice
  • Place of Presentation: Gate Garchinger Technologie, Garching (Germany)
  • Year and Date: 2016-09-12 – 2016-09-12
  • Int'l Joint Research / Invited
• [Presentation] Study on the moving striation phenomena of a low energy atmospheric pressure neon plasma flare using a high speed camera (2016)
  • Author(s): Y. Fujiwara, H. Sakakita, H. Yamada, H. Itagaki, S. Kiyama, M. Fujiwara, S. Kato, Y. Ikehara, J. Kim
  • Organizer: 6th International Conference on Plasma Medicine (ICPM-6)
  • Place of Presentation: Comenius University and Slovak University of Technology, Bratislava (Slovakia)
  • Year and Date: 2016-09-06 – 2016-09-06
  • Int'l Joint Research
• [Presentation] Study on Propagation Mode (Bullet or Striation) of a Low Energy Atmospheric Pressure Plasma (2016)
  • Author(s): H. Yamada, H. Sakakita, Y, Fujiwara, T. Hotta, J. Kim, H. Itagaki, M. Fujiwara, S. Kato, S. Kiyama, N. Shimizu, H. Nakanishi, Y. Ikehara
  • Organizer: 6th International Conference on Plasma Medicine (ICPM-6)
  • Place of Presentation: Comenius University and Slovak University of Technology, Bratislava (Slovakia)
  • Year and Date: 2016-09-06 – 2016-09-06
  • Int'l Joint Research
• [Presentation] Time evolutions of metastable helium atoms in a Low Energy Atmospheric Pressure Plasma using a laser absorption spectroscopic measurement (2016)
  • Author(s): T. Hotta, A. Nonaka, H. Yamada, A. Okamoto, S. Kitajima, S. Kato, H. Itagaki, M. Fujiwara, H. Sakakita
  • Organizer: 6th International Conference on Plasma Medicine (ICPM-6)
  • Place of Presentation: Comenius University and Slovak University of Technology, Bratislava (Slovakia)
  • Year and Date: 2016-09-06 – 2016-09-06
  • Int'l Joint Research
• [Presentation] Power Distributions of Each Impedance in the Electrical Circuit of Ionized Gas Coagulation Equipment (2016)
  • Author(s): H. Sakakita, S. Kiyama, J. Kim, H. Yamada, T. Niwa, N. Shimizu, Y. Seto, M. Ichinose, Y. Ikehara
  • Organizer: 6th International Conference on Plasma Medicine (ICPM-6)
  • Place of Presentation: Comenius University and Slovak University of Technology, Bratislava (Slovakia)
  • Year and Date: 2016-09-06 – 2016-09-06
  • Int'l Joint Research
• [Presentation] Review of plasma characteristic measurements of a Low Energy Atmospheric Pressure Plasma for Blood Coagulation (2016)
  • Author(s): H. Yamada, T. Hotta, H. Sakakita, Y. Fujiwara, J. Kim, H. Itagaki, M. Fujiwara, S. Kato, S. Kiyama, N. Shimizu, H. Nakanishi, Y. Ikehara
  • Organizer: 6th International Conference on Plasma Medicine (ICPM-6)
  • Place of Presentation: Comenius University and Slovak University of Technology, Bratislava (Slovakia)
  • Year and Date: 2016-09-06 – 2016-09-06
  • Int'l Joint Research
• [Presentation] Mechanism of blood coagulation induced by plasma treatment in addition to the acceleration of the natural blood coagulation process. (2016)
  • Author(s): Y. Ikehara, S. Ikehara, Y. Akimoto, H. Sakakita, K. Ishikawa, M. Ueda, J.Ikeda, J. Kim, T.Yamaguchi, H. Sakakita,T. Shimizu, N. Shimizu, M. Hori
  • Organizer: 6th International Conference on Plasma Medicine (ICPM-6)
  • Place of Presentation: Comenius University and Slovak University of Technology, Bratislava (Slovakia)
  • Year and Date: 2016-09-06 – 2016-09-06
  • Int'l Joint Research / Invited
• [Presentation] 医療用マイルドプラズマのよる創傷治癒の確立とプラズマー組織細胞交互作用の解明 (2016)
  • Author(s): 池原 譲
  • Organizer: 第57回組織細胞化学会 総会・学術集会シンポジウム
  • Place of Presentation: 杏林大学(東京都・三鷹市）
  • Year and Date: 2016-09-04 – 2016-09-04
  • Invited
• [Presentation] Microwave excited plasma sources using microstrip line (2016)
  • Author(s): J. Kim, H. Sakakita, H. Itagaki
  • Organizer: 20th International Vacuum Conference
  • Place of Presentation: Busan Exhibition Convention Center, 釜山（韓国）
  • Year and Date: 2016-08-26 – 2016-08-26
  • Int'l Joint Research
• [Presentation] Time resolved behavior of metastable helium atoms in a low energy atmospheric pressure plasma using a laser absorption spectroscopic measurement (2016)
  • Author(s): T. Hotta, A. Nonaka, H. Yamada, A. Okamoto, S. Kitajima, S. Kato, M. Fujiwara, H. Itagaki, H. Sakakita
  • Organizer: 20th International Vacuum Conference
  • Place of Presentation: Busan Exhibition Convention Center, 釜山（韓国）
  • Year and Date: 2016-08-24 – 2016-08-24
  • Int'l Joint Research
• [Presentation] Characteristic Measurements of a Low Energy Atmospheric Pressure Plasma for blood coagulation (2016)
  • Author(s): H. Yamada, H Sakakita, Y. Fujiwara, T. Hotta, J. Kim, H. Itagaki, M. Fujiwara, S. Kato, S. Kiyama, N. Shimizu, H. Nakanishi, Y. Ikehara
  • Organizer: 20th International Vacuum Conference
  • Place of Presentation: Busan Exhibition Convention Center, 釜山（韓国）
  • Year and Date: 2016-08-24 – 2016-08-24
  • Int'l Joint Research
• [Presentation] 超1000nm近赤外波長域のイメージングと利用技術 (2016)
  • Author(s): 池原 譲
  • Organizer: 第35回日本医用画像工学会
  • Place of Presentation: 千葉大学（千葉県・千葉市）
  • Year and Date: 2016-07-21 – 2016-07-21
  • Invited
• [Presentation] Plasmatreatment Induces Blood Clot Formation; Protein Aggregation and Hemoysisi (2016)
  • Author(s): Y. Ikehara
  • Organizer: 43rd IEEE International Conference on Plasma Science, (ICOPS)
  • Place of Presentation: The Banff Centre, Alberta（Canada）
  • Year and Date: 2016-06-19 – 2016-06-19
  • Int'l Joint Research / Invited
• [Presentation] Development of a new imaging technology to use over-1000nm near infrared wave length for histopathology and cytology. (2016)
  • Author(s): Y. Ikehara
  • Organizer: ICC2016
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-05-28 – 2016-05-28
  • Int'l Joint Research / Invited
• [Presentation] Ionized Gas Coagulation Equipmentの電気回路系としての各構成部のパワー分布の検討 (2016)
  • Author(s): 榊田 創、木山 学、金 載浩、山田 大将、増金 勲、丹羽徹、清水伸幸、瀬戸泰之、一瀬雅夫、池原 譲
  • Organizer: 第３回産総研プラズマ研究会
  • Place of Presentation: 産総研(茨城県・つくば市）
  • Year and Date: 2016-05-17 – 2016-05-17
• [Presentation] 低エネルギー大気圧プラズマフレアーのストリエーション現象の解析 (2016)
  • Author(s): 藤原 大、榊田 創、山田 大将、板垣 宏知、山岸祐介、木山 学、藤原 正純、池原 譲、金 載浩
  • Organizer: 第３回産総研プラズマ研究会
  • Place of Presentation: 産総研(茨城県・つくば市）
  • Year and Date: 2016-05-17 – 2016-05-17
• [Presentation] エネルギー大気圧プラズマと生体物質との相互作用に関する研究 (2016)
  • Author(s): 山田 大将、堀田 朋敬、榊田 創、加藤 進、板垣 宏知、金 載浩、藤原 正純、木山 学、池原 早苗、中西速夫、清水伸幸、池原 譲
  • Organizer: 第３回産総研プラズマ研究会
  • Place of Presentation: 産総研(茨城県・つくば市）
  • Year and Date: 2016-05-17 – 2016-05-17
• [Presentation] エレクトロニクス産業における次世代プロセスプラズマの開発 (2016)
  • Author(s): 金 載浩、榊田 創、板垣 宏知
  • Organizer: 第３回産総研プラズマ研究会
  • Place of Presentation: 産総研(茨城県・つくば市）
  • Year and Date: 2016-05-17 – 2016-05-17
• [Presentation] 大気圧プラズマ中準安定ヘリウム粒子の近赤外レーザー吸収分光計測 (2016)
  • Author(s): 堀田 朋敬、野中 淳司、山田 大将、岡本敦、北島純男、加藤 進、板垣 宏知、藤原 正純、榊田 創
  • Organizer: 第３回産総研プラズマ研究会
  • Place of Presentation: 産総研(茨城県・つくば市）
  • Year and Date: 2016-05-17 – 2016-05-17
• [Patent(Industrial Property Rights)] プラズマ照射処理装置、その制御方法、凝固物の評価装置、及び、膜の製造方法 (2016)
  • Inventor(s): 池原 譲、池原 早苗
  • Industrial Property Rights Holder: 池原 譲、池原 早苗
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-129295
  • Filing Date: 2016-06-29
• [Patent(Industrial Property Rights)] 内包フラーレン生成装置及び生成方法 (2016)
  • Inventor(s): 藤原大、板垣宏知、榊田創、箕輪祐貴、池原譲、岡崎俊也、飯泉陽子
  • Industrial Property Rights Holder: 藤原大、板垣宏知、榊田創、箕輪祐貴、池原譲、岡崎俊也、飯泉陽子
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-161077
  • Filing Date: 2016-08-19
• [Patent(Industrial Property Rights)] 幹細胞様細胞の調製方法 (2016)
  • Inventor(s): 池原 譲
  • Industrial Property Rights Holder: 池原 譲
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016- 195112
  • Filing Date: 2016-09-30
• [Patent(Industrial Property Rights)] プラズマ評価装置 (2012)
  • Inventor(s): 榊田 創,池原 譲、木山 学
  • Industrial Property Rights Holder: 榊田 創,池原 譲、木山 学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-234839
  • Filing Date: 2012-10-24
  • Acquisition Date: 2017-01-20