2016 Fiscal Year Final Research Report
Microendophenotype of psychiatric disorders by glutamatergic signal
Project Area | Unraveling micro-endophenotypes of psychiatric disorders at the molecular, cellular and circuit levels. |
Project/Area Number |
24116006
|
Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
|
Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
|
Research Institution | Chiba University |
Principal Investigator |
Kenji Hashimoto 千葉大学, 社会精神保健教育研究センター, 教授 (10189483)
|
Co-Investigator(Renkei-kenkyūsha) |
ISHIMA Tamaki 千葉大学, 社会精神保健教育研究センター, 特任助教 (00597130)
|
Research Collaborator |
FUJITA Yuko 千葉大学, 社会精神保健教育研究センター, 特任助教 (40623591)
|
Project Period (FY) |
2012-06-28 – 2017-03-31
|
Keywords | 脳・神経疾患 / 統合失調症 / うつ病 / ストレス / NMDA受容体 / Dセリン / ケタミン |
Outline of Final Research Achievements |
Ketamine enantiomers are the most attractive antidepressants.Repeated administration of S-ketamine, but not R-ketamine, caused the loss of parbalubumin-positive cells in the prefrontal cortex. In the social defeat stress model of depression, (2R,6R)-hydroxynorketamine, a final metabolite of R-ketamine, did not show antidepressant-like effects. In the PolyIC model of schizophrenia, treatment of D-serine from 4-week olds to 8-week olds can prevent the onset of behavioral abnormality in adult offspring after maternal immune activation.
|
Free Research Field |
精神神経科学
|