2017 Fiscal Year Final Research Report
Studies on molecular mechanism of dynamic ordering and disassembling of biomolecular systems
| Project Area | Dynamical ordering of biomolecular systems for creation of integrated functions |
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| Project/Area Number |
25102004
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2013-06-28 – 2018-03-31
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| Keywords | タンパク質 / 反応 / 時間分解 / 拡散係数 / 分子間相互作用 |
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| Outline of Final Research Achievements |
Dynamical association and dissociation processes are essentially important for biological functions of biomolecules. To reveal the dynamical ordering of proteins and DNA, several new methods for detections of the intermolecular interaction and stability in time-domain have been developed based on the transient grating method, which can monitor the translational diffusion and thermodynamical properties in time domain. Using these methods, it was found that the structural fluctuation controls the association/dissociation reactions. Furthermore, for many photosensor proteins, increase and/or decrease in the intermolecular interaction during the protein reactions were observed. These observations are important to understand the molecule mechanism of the dynamical association/dissociation processes.
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| Free Research Field |
生物物理化学
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