Time-resolved Observation and Elucidation of Functionally-important Molecular Flexibility

2017 Fiscal Year Final Research Report

• Project Area: Science on Function of Soft Molecular Systems by Cooperation of Theory and Experiment
• Project/Area Number: 25104006
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Osaka University
• Principal Investigator: Mizutani Yasuhisa 大阪大学, 理学研究科, 教授 (60270469)
• Co-Investigator(Kenkyū-buntansha): 水野 操 大阪大学, 理学研究科, 助教 (10464257) ; 石川 春人 大阪大学, 理学研究科, 講師 (40551338)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Keywords: ラマン分光学 / アロステリー / 時間分解分光学

Outline of Final Research Achievements

Proteins can exhibit high functionality which artificial molecules cannot do. Thus, understanding of protein helps us not only to understand life phenomena but also to create highly functional molecules. Because coupling of functional units in structural changes is indispensable for proteins to function, dynamic structure as well as static one of proteins is needed to be elucidated. We revealed structural changes important for allostery and energy flow driving functionally-important motions mainly by using time-resolved resonance Raman spectroscopy.

Free Research Field

生物物理化学