2017 Fiscal Year Final Research Report
Molecular mechanisms for empathetic systems
| Project Area | Empathic system |
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| Project/Area Number |
25118007
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Complex systems
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| Research Institution | Azabu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
茂木 一孝 麻布大学, 獣医学部, 准教授 (50347308)
永澤 美保 麻布大学, 獣医学部, その他 (70533082)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGASAWA Miho 麻布大学, 獣医学部, 講師 (70533082)
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| Project Period (FY) |
2013-06-28 – 2018-03-31
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| Keywords | マウス / 情動伝染 / 帯状回 / 中脳水道周囲灰白質 / オキシトシン / 心拍変動解析 / 涙 |
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| Outline of Final Research Achievements |
In mice, visual and olfactory cues are responsible for fear-contagion. In observer mice, ACC to PAG circuits in the brain is involved in fear-contagion. TRPV1 is also a regulatory molecule in this circuit. The mice weaned earlier showed decreased capacity of emotional contagion, and physical contact from mom increased ACC oxytocin release in pups. If this oxytocin was blocked, their social cognition and affiliation was impaired.
In dog-human dyad, eye-gaze contact increase oxytocin release in both, and if the dog watch the owner, their emotion became similar to that of the owners. When dogs reunite with their owners, they secret tears via oxytocin.
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| Free Research Field |
動物行動学
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