Molecular mechanisms of cell competition between normal and transformed cells

2018 Fiscal Year Final Research Report

• Project Area: Cell competition: a mechanism for survival of the fittest in the multi-cellular community
• Project/Area Number: 26114008
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Hokkaido University
• Principal Investigator: Fujita Yasuyuki 北海道大学, 遺伝子病制御研究所, 教授 (50580974)
• Co-Investigator(Kenkyū-buntansha): 伊藤 俊樹 神戸大学, バイオシグナル総合研究センター, 教授 (30313092)
• Project Period (FY): 2014-07-10 – 2019-03-31
• Keywords: 細胞競合

Outline of Final Research Achievements

The study has been steadily developed, and we have eventually acquired quite satifcatroy achievement.
I will briefly summarized the main publications. 1) Identification of cell competition regulators (Anton et al., 2014, JCS; Ohoka et al., 2015, JCS); 2)Involvement of endocytosis in cell competition (Saitoh et al., 2017, PNAS); 3) Involvement of metabolism in cell competition (Kon et al., 2017, Nat Cell Biol); 4) Cell competition between normal and p53-mutated epithelial cells (Watanabe et al., 2018, Cell Rep); 5) Obesity suppresses apical elimination of RasV12-transformed cells through cell competition (Sasaki et al., 2018, Cell Rep)

Free Research Field

分子腫瘍学

Academic Significance and Societal Importance of the Research Achievements

スクリーニングで同定された細胞競合候補分子について、領域班内の様々なモデルシステムを用いて解析を進めることによって、多彩な細胞競合現象を司る普遍的な制御因子の同定を目指す。本研究を精力的に推進することによって今後「周囲の正常細胞に変異細胞を攻撃させる」というがんの社会性を利用した全く新たながん予防・治療戦略の開発へとつなげていく。