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1990 Fiscal Year Final Research Report Summary

Biomechanics on the Growth and Deformation of Living Tissues and its Applications to Engineering

Research Project

Project/Area Number 01044009
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionHokkaido Univ.

Principal Investigator

HAYASHI Kozaburo  Research Institute of Applied Electricity, Hokkaido University, 応用電気研究所, 教授 (90026196)

Co-Investigator(Kenkyū-buntansha) WOO Savio L-Y  Dept. Orthopaedic Surgery, Univ. of California, San Diego, サンディエゴ校・整形外科, 教授
FUNG YuanーCh  カリフォルニア大学, サンディエゴ校・応用力学・物理工学科, 教授
TANAKA Masao  School of Engineering Sciences, Osaka Univ., 基礎工学部, 助手 (40163571)
SEGUCHI Yasuyuki  School of Engineering Sciences, Osaka Univ., 基礎工学部, 教授 (20031073)
MATSUMOTO Takeo  Research Institute of Applied Electricity, Hokkaido Univ., 応用電気研究所, 助手 (30209639)
YAMAMOTO Noritaka  Research Institute of Applied Electricity, Hokkaido Univ., 応用電気研究所, 助手 (40210546)
TADANO Shigeru  School of Engineering, Hokkaido Univ., 工学部, 講師 (50175444)
NAKAMURA Takao  Research Institute of Applied Electricity, Hokkaido Univ., 応用電気研究所, 講師 (00142654)
ISHIKAWA Hiromasa  School of Engineering, Hokkaido Univ., 工学部, 教授 (80001212)
FUNG Yuan-chen B  Dept. Appl. Mech. Eng. Sci., Univ. of California, San Diego
Project Period (FY) 1989 – 1990
KeywordsBiomechanics / Living tissues and organs / Bio-control / Bio-function / Functional adaptation / Optimal design / Model and simulation / Computation
Research Abstract

The purposes of this project were : 1) to study the functional adaptation of living tissues and organs to various mechanical environment, 2) to apply the optimal adaptation mechanisms to the development of new engineering methodologies, and 3) to establish a new organization for international cooperative research activities. The main results obtained are :
1. Arterial wall thickness increased promptly with the increase in blood pressure, Keeping the wall stress within a physiological range, followed by the change in such material properties as elastic modulus.
2. Release of tension in the patellar tendon decreased the tensile strength (fracture load divided by initial cross sectional area) rapidly and remarkably, while the strength was not changed by over-stressing. In response to these variation of mechanical environment, the cross sectional area of ligament increased compensatively to keep the structural strength at a normal level.
3. Air way-lung system was modelled considering the gas … More transportation in the air way, deformation behavior and surface tension of the lung, gas exchange between the alveolus and blood, and so on, which was successfully applied to simulate the respiratory mechanics.
4. An in-plane stress-based 3-D finite element model was proposed for the stress/strain analyses in the human whole lumbar spine, and successfully applied to analyze the stress distribution in each component of the normal and diseased spines exposed to various load condition.
5. The functional adaptation observed with living systems has possibilities of being applied to engineering field, for example, like the growth strain method for structural design. The technique developed to analyze the solid-fluid-gas interaction in biological systems would be very useful for the design and analysis of similar complex engineering systems.
6. By the action of the investigators for this project, the World Committee for Biomechanics has been established for the efficient exchange of information and international cooperative studies. Less

  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] K.Hayashi: "Biomechanical approach to the design of vascular prostheses" Tissue Engineering ー 1989. 5-10 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Yamamoto: "Effects of stress Shielding on the mechanical properties ofpatellar tendon" Tissue Engineering ー 1989. 103-106 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Nakamura: "Effect of longーterm pumping of cardiac assist device on the left ventricular mechanics (In the case of normal heart)" Artificial Organs.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Yamamoto: "Mechanical properties of the rabbit patellar tendon" ASME,Journal of Biomechanical Engineering.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Yamamoto: "Effects of stress shielding on the mechanical properties of rabbit patellar tendon" ASME,Journal of Mechanical Engineering.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Ohno: "Effects of stress shielding on the mechanical properties of normal and in situ frozen patellar tendon" Proc.37th Ann.Meet.Orth.Res.Soc.(1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Tadano: "A finite element model on whole Iumber spine in flexion" Tissue Engineering ー 1989. 71-74 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 但野 茂: "全腰つい(椎)の前方屈曲シミュレ-ション" 日本機械学会論文集. 56. 1885-1892 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 但野 茂: "生体内椎間板矢状面に生じるひずみ分布" 日本機械学会論文集.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Seguchi: "Preliminar study on adaptation by remodeling" Tissue Engineering ー 1989. 75-78 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Tanaka: "A note on the ACL deformation under tensile loading along ligament and/or tibia direction" Tissue Engineering ー 1989. 115-118 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Wada: "Simulation of breathing and ventilation combined with body circulation" 1990 Advances in Engineering. 67-70 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Wada: "Breathingーventilation model,and simulation of highーfrequency ventilation" JSME International Journal. 34. 98-105 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.C.Fung: "The future of biomechanics" 第2回バイオメカニクスカンファレンス講演論文集. 3 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.LーY.Woo: "Biomechanical evaluation of human anterior cruciate ligament" 第2回バイオメカニクスカンファレンス講演論文集. 1-2 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K. Hayashi: "Biomechanical approach to the design of vascular prostheses" Tissue Engineering - 1989. 5-10 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N. Yamamoto, K. Ohno, H. Kuriyama, K. Yasuda, K. Hayashi and K. Kaneda: "Effects of stress shielding on the mechanical properties of patellar tendon" Tissue Engineering - 1989. 103-106 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Nakamura, K. hayashi, J. Seki, S. Fukuda, H. Noda, T. Nakatani, H. Takano and T. Akutsu: "Effects of long-term pumping of cardiac assist device on the left ventricular mechanics (In the case of normal heart)" Artificial Organs.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N. Yamamoto, K. Ohno, K. Hayashi, H. Kuriyama, K. Yasuda and K. Kaneda: "Mechanical properties of the rabbit patellar tendon" ASME, Journal of Biomechanical Engineering.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N. Yamamoto, K. Ohno, K. Hayashi, H. Kuriyama, K. Yasuda and K. Kaneda: "Effects of stress shielding on the mechanical properties of rabbit patellar tendon" ASME, Journal of Biomechanical Engineering.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Ohno, K. Yasuda, N. Yamamoto and K. Hayashi: "Effects of stress shielding on the mechanical properties of normal and in situ frozen patellar tendon" Proc. 37th Ann. Meet. Ortopaedic Research Society. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Tadanao, H. Ishikawa, I. Yamamoto and K. Kaneda: "A finite element model on whole lumbar spine in flexion" Tissue Engineering - 1989. 71-74 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Tadano, H. Ishikawa, I. Yamamoto and K. Kaneda: "Computational simulation of the whole lumbar spine under flexion" Trans. Jap. Soc. Mech. Eng.56. 1885-1892 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Tadano, H. Ishikawa, M. Itoh and K. Kaneda: "Strain distribution on the sagittal plane of an intervertebral disc" Trans. Jap. Soc. Mech. Eng.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Seguchi: "Preliminary study on adaptation by remodeling" Tissue Engineering - 1989. 75-78 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Tanaka, Y. Seguchi, T. Mizutani and M. Inoue: "A note on the ACL deformation under tensile loading along ligament and/or tibia direction" Tissue Engineering - 1989. 115-118 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Wada, Y. Seguchi and M. Tanaka: "Simulation of breathing and ventilation combined with body circulation" 1990 Advances in Bioengineering. 67-70 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Wada, Y. Seguchi and M. Tanaka: "Breathing-ventilation model, and simulation of high-frequency ventilation" JSME International Journal. 34. 98-105 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. C. Fung: "The future of biomechanics" Proc. 2nd JSME Conference on Biomechanics. 3 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. L-Y. Woo: "Biomechanical evaluation of human anterior cruciate ligament" Proc. 2nd JSME Conference on Biomechanics. 1-2 (1991)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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