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1990 Fiscal Year Final Research Report Summary

Causes of the Biliary Tract Cancer from the Point of View of Environmental Epidemiology

Research Project

Project/Area Number 01570286
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionNiigata University

Principal Investigator

YAMAMOTO Masaharu  Niigata University School of Medicine, Professor, 医学部, 教授 (40018693)

Co-Investigator(Kenkyū-buntansha) TAKAGI Shuko  Niigata University School of Medicine, Research Associate, 医学部, 助手 (30134109)
WATANABE Gen-ichi  Niigata University School of Medicine, Professor Emeritus, 名誉教授 (50018280)
Project Period (FY) 1989 – 1990
KeywordsBiliary tract cancer / Human bile / Rec assay / Mutagenicity / Selenium
Research Abstract

(1) Rec assay of human bile
Epidemiological studies revealed that the death rate for the biliary tract cancer in Niigata Prefecture has been the highest in japan since 1958. In order to examine whether or not the human bile in Niigata is mutagenic, we tested the bile collected in Niigata by means of rec assay and compared with the rate of mutagenic activity of the bile in Kochi Prefecture, where the death rate has been relatively low in Japan. Spore rec assay of human bile was conducted by the Bacillus subtilis test system to examine possible mutagenicity and co-mutagenicity. Of 65 samples in Niigata Prefecture examined, 3(4.6%) Showed mutagenic activity. In 26 samples in Kochi Prefecture, none was mutagenic. There was no statistical significance in frequencies of mutagenicity between Niigata and Kochi Prefectures.
(2) Selenium contents in human gallbladder bile
The selenium contents in human gallbladder bile were analyzed. Thirty- Seven subjects were studied ; 22 Patients with cholelithiasis in Niigata and 15 patients (13 with cholelithiasis and 2 with gallbladder polypus) in Kochi Prefecture. Five ml of bile was withdrawn withdrawn with a syringe from the gallbladder during the operation and stored at -20^゚C until analysis. For the analysis by gas chromatograph with an electron-capture detector, 0.2 ml of sample was used. The mean selenium contents in bile were 269 <plus-minus>39.0 (mean<plus-minus>S.D.) ng/ml for the subjects in Niigata and 285 <plus-minus>84.4ml in Kochi ; without significant difference.

  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] 陳偉師,他: "Selenium Contents in Human Gallbladder Bile" Tohoku J.Exp.Med.161. 257-259 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 渋谷 範夫,他: "CoーMutagenic Activity of phenoxyherbicides MCPAーand MCPBーEthylesters in the Ames Assay" Tohoku J.Exp.Med.160. 167-168 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 陳偉師,他: "International Comparison of the Mortalites of Biliary Tract Cancer" J.Aichi Med.Univ.Assoc.18. 187-192 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山本 正治,他: "胆道癌 1)記述疫学" 胆肝膵. 22. (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] CHEN, WEISHI et al.: "Selenium contents in human gallbladder bile" Tohoku J. Exp. Med.161. 257-259 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] SHIBUYA, NORIO et al.: "Co-mutagenic activity of phenoxyherbicides MCPA-and MCPB-ethylesters in the Ames assay" Tohoku J. Exp. Med.160. 167-168 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] CHEN, WEISHI et al.: "International comparison of the mortalities of biliary tract cancer" J. Aichi Med. Univ. Assoc.18. 187-192 (1990)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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