1991 Fiscal Year Final Research Report Summary
Late Radiation Effects of Low Doses from Occupational Exposure.
| Project/Area Number |
01580214
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
放射線5生物学
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| Research Institution | Kumamoto University |
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Principal Investigator |
KUMAGAI Etsuko Kumamoto University, College of Medical Science, Researcher, 医療技術短期大学部, 助手 (80145341)
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| Project Period (FY) |
1989 – 1991
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| Keywords | Occupational Exposure / Low Dose Radiation / Radiological Technologist / ATL Cell / Chromosomal Aberration / HTLV-1 Antibody / EB Virus Antibody / Cytomegalovirus Antibody |
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| Research Abstract |
Kumamoto prefecture in Japan is one of endemic areas of adult T cell leukemia (ATL). Therefore, in this study, the relationship between human T cell leukemia virus type 1 (HTLV-1) infection and exposure to low doses of radiation in radiological technologist (RT) was studied.
The incidence of HTLV-1 antibodies was identified in 3 (3.0%) of 99 RT and 4 (4.2%) of 96 controls. A RT of HTLV-1 carriers was diagnosed as chronic ATL in Kumamoto University hospital. The WBC count was 8500/mm^3 with about 50% abnormal lymphocytes, and Ca levels was 9.2mg/dl. However, other HTLV-1 carriers had not abnormal lymphocyte. Structural aberrations were identified in 384 (2.5%) of 15, 442 cells analyzed from 53 RT as compared to 177 (1.6%) of 11136 cells from 36 healthy controls. Most of structural. aberrations in both groups was translocations and the frequency was significantly higher in the RT than in the controls. 7/14 translocations were the most frequent reciprocal translocations in RT. However, the frequency of 7/14 translocations was not significantly different between the RT and controls. In these cases, most of the break points were localized in band 14q11-12 and 7q32-36. It was reported that most Japanese patients with ATL had abnormalities of chromosome 14 a band 14q11. However, none of the HTLV-1 carriers demonstrated clones of cell with this chromosomal abemations. At the chromosomal sites which were related to the sites of ski abl, myb, mos, myc, N-myc oncogenes, very low incidences of translocation were detected in RT. However, none of the RT demonstrated abnormal clones of cells with identical chromosomal aberrations.
Also, the relationship between EB virus (EBV) antibodies and cytomegalovirus (CMV) antibodies and e e to radiation in 96 RT and 99 controls was studied. The RT in service over many years of experience often had increased EBV antibody titers, but there was no correlation between exposure and CMV antibodies.
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Research Products
(2 results)
