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1991 Fiscal Year Final Research Report Summary

Elucidation of Biosynthesis and Metabolism of Nicotinic Acid Related Compounds and Various Specific Physiological Functions of the compounds

Research Project

Project/Area Number 02660089
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 応用生物化学・栄養化学
Research InstitutionMie University

Principal Investigator

TAGUCHI Hiroshi  Mie University, Department of Bioresources, Associate Professor, 生物資源学部, 助教授 (60024593)

Project Period (FY) 1990 – 1991
KeywordsCinchomeronic acid / Growth-promoting effect / Radish seedling / Indoleacetic acid / Escherichia coli / Nicotinic acid related compounds / Cultured animal cells / Homarine
Research Abstract

1. Growth-prmoting Effect of Cinchomeronic Acid (CA)
(1) On Radish Seeding : Maximum growth of the stem was observed at 10mM of CA and it was 2.18 times longer than that of control. Cell length was several times longer and cell width was about the half as compared to those of the control on microscopic obervation of the epidermal cells of radish stems. Indoleacetic acid slightly promoted the growth of radish seedings.
(2) On Escherichia coli and Other Microorganisms : At 0.1-100mM of CA with E. coli B was most effective among various microorganisms (lactic acid bacteria, E. coli, Bacillus subtiis, yeast).
2. Metabolism of Cinchomeronic Acid in Plants and Microorganisms No radioactive peak other than CA was observed in the extract from duckweed and E. coli B grown in the medium containing [3, 4, 7, 8-^<14>C] CA on radio HPLC analysis. Also no radioactive peak except CA was observed in the reaction mixture after incubating [^<14>C] CA with the cell-free extract from duckeweed and E. coli B. Hence, CA may not be metabolized in the these organisms.
3. Function of Various Nicotinic acid-Related Compounds
(1) On Cultured Animal cells : Almost all compounds added to the medium of 3 kinds of animal cells were inhibitory.
(2) On Flowering Induction in Duckweed : Relationship between intrinsic nicotinic acid-, nicotinamide-, and NAD-contents and flowering induction was not found.
4. Biosynthesis of Homarine in marine Invertebrates
Proposed pathway from glycine to homarine can not be supported with various investigations.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 田口 寛: "ダイコン幼植物に対するシンコメロン酸の生長促進作用" ビタミン. 65. 63-70 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田口 寛: "アオウキクサ(Lemna paucicostata 151)のニコチンアミダ-ゼの性質ならびに花芽誘導との関連性の考察" 三重大学生物資源学部紀要. 7号. 77-82 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田口 寛: "ニコチン酸関連化合物による動物培養細胞の増殖阻害" 三重大学生物資源学部紀要. 8号. (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田口 寛: "シンコメロン酸による大腸菌の生育促進効果" ビタミン. 66. (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroshi Taguchi: "Relationship between the Growth-promoting Effect of Cinchomeronic Acid and Intrinsic Indoleacetic Acid Content in the Seedling of Radish(Raphanus sativus L.)" Biosci.Biotech.Biochem.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroshi Taguchi: "Growth-Promoting Effect of Cinchomeronic Acid on the Seedling of Radish (Raphanus sativus L.)" Vitamins. 65. 63-70 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroshi Taguchi: "Properties of Nicotinamidase in the Duckweed (Lemna paucicostata 151) and Considerations in Relation to Flowering-Induction of the Plant" The Bulletin of the Faculty of Bioresources, Mie University. No. 7. 77-82 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroshi Taguchi: "Growth Inhibition of Cultured Animal Cells with Nicotinic Acid Related Compounds" The Bulletin of the Faculty of Bioresources, Mie University. No. 8. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroshi Taguchi: "Growth Promoting Effect of Cinchomeronic Acid on Escherichia coli Strains," Vitamins. 66. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroshi Taguchi: "Relationship between the Growth-Promoting Effect of Cinchomeronic Acid and Intrinsic Indoleacetic Acid Content in the Seeding of Radish (Raphanus sativus L.)" Biosci. Biotech. Biochem.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-16  

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