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1991 Fiscal Year Final Research Report Summary

Induction of thyroid C cell function and its mechanism.

Research Project

Project/Area Number 02670141
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionWakayama Medical College

Principal Investigator

KAKUDO K.  Wakayama Med Coll, Pathology, Professor, 第2病理, 教授 (00112037)

Co-Investigator(Kenkyū-buntansha) TAKEKOSHI S.  Tokai Univ Med Sch, Pathol, assistant, 医学部・病理学, 助手 (70216878)
Project Period (FY) 1990 – 1991
KeywordsC cell / Thyroid / Cell differentiation / Tumor differentiation / Secretion / Hormone synthesis / Lysosome
Research Abstract

For the purpose of studying effects of synthetic salmon calcitonin (TZ-CT) on CT synthesis and cell cycle of rat thyroid C cell, the following three experiments were carried out :
In experiment #1, effects of long term administration of TZ-CT on C cell population were evaluated immunohistochemically. Administration of TZ-CT 30IU/kg and 12OIU/kg for 53 weeks caused a dose-dependent, statistically significant reduction of the C cell population without the alteration of serum calcium levels. Electron microscopic examination showed no significant ultrastructural changes in C cells of both experimental and control groups.
In experiment #2, administration of TZ-CT 0.5IU/kg and 10OIU/kg for a short term (14 days) caused dose-dependent reduction of CT and CT-mRNA in the rat thyroid.
In experiment #3, effects of a short term administration of TZ-CT on C cell cycle were investigated. Administration of TZ-CT 0.4IU/kg and 40IU/kg for 15 days induced dose-dependent suppression of S phase C cell ratio to total C cells without decrease of C cell to the total thyroid cell ratio. These results may suggest that exogenous TZ-CT induces negative feedback to synthesis of CT and the proliferation of C cells of the thyroid.
Ultraviolet (254nm, 5J/m^2) on poorly differentiated C cell tumor line (HMCa) resulted in increased CT production after 96 hours, while over lOJ/m^2 ultraviolet resulted in cell degeneration.

  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] 小田 高司他: "甲状腺癌における血液型関連糖鎖抗原の変異:免疫組織化学的検討" 内分泌外科. 8. 67-72 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 高見 博他: "副腎皮質刺激ホルモン産生甲状腺髄様癌" 腫瘍マ-カ-研究会記録. 10. 269-270 (1991)

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      「研究成果報告書概要(和文)」より
  • [Publications] 覚道 健一他: "カルシトニンの基礎、カルシトニンの分泌調節" 骨・関節・靭帯. 4. 625-633 (1991)

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      「研究成果報告書概要(和文)」より
  • [Publications] Lertpraseetsuke,N.et al.: "Functional interpretation of the kidney Juxtaglomerular apparatus using renin immunohistochemistry." Tokai J Exp Clin Med. 15. 317-326 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tauchi,K.et al.: "Immunohistochemical studies of blood group-related antigens in human superficial esophageal carcinomas." Cancer. 67. 3042-3050 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Morikawa,Y.et al.: "The role of antibodies in the regulation of delayedtype hypersensitivity." Immunology. 74. 146-152 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 覚道 健一: "病理学キ-ワ-ド" 文光堂, 424 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 覚道 健一: "甲状腺" 文光堂, 174 (1991)

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      「研究成果報告書概要(和文)」より
  • [Publications] N. Lertprasertsuke, K. Kakudo, Y. Osamura, Y. Nomoto, H. Sakai & K. Watanabe: "Functional interpretation of the kidney Juxtaglomerular apparatus using renin immunohistochemistry in Batter's, pseudo-Batter's and Conn's syndromes." Tokai J Exp Clin Med. 15. 317-326 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Tauchi, K. Kakudo, T. Machimura, H. Makuuchi, T. Mitomi: "Superficial esophageal carcinoma : with special reference to basaloid expansive growth." Pathol Res Pract. 186. 450-454 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Katoh, K. Shimamura, K. Kakuko, Y. Osamura & K, Tamaoki: "An autopsy case of a cystic variant of thymic carcinoma mimicing a thymic cyst." Virch Arch A path Anat. 417. 85-87 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N. Lertprasertsuke, K. Yazaki, K. Kakudo, N. Tada, Y. P. Osamura: "Rectal carcinoid tumor metastatizing to the thyroid and pancreas : An autopsy case aided by immunohistochemistry in differentiating tumor involving multiple endocrine organs." Acta Pathol Jpn. 40. 352-360 (1990)

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      「研究成果報告書概要(欧文)」より
  • [Publications] K. Ito, K. Kakudo, I. Mori, M. Horiuchi, Y. P. Osamura: "Neuroendocrine differentiation in a case of acinic cell carcinoma of the parotid gland." Acta Pathol Jpn. 40. 279-287 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Takami, J. Shikata, K. Kakudo, K. Ito: "Calcitonin gene-related peptide in patients with endocrine tumors." J. Surg Oncol. 43. 28-32 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Tauchi, K. Kakudo, T. Machimura, H. Makuuchi, T. Mitomi: "Immunohistochemical studies of blood group-related antigens in human superficial esophageal carcinomas." Cancer. 67. 3042-3050 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Kakudo, I. Iteya, N, Matsuura, S. Takekoshi: "Basic science of calcitonin. Regulation of calcitonin secretion." Bone Joint Ligament. 4. 625-633 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Morikawa, K. Kuribayashi, F. Yoshikawa, K. Fujita, A. Mizushima & K. Kakudo: "The role of antibodies in the regulation of delayed-type hypersensitivity." Immunology. 74. 146-152 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Kakudo, H. Takami, S, Katayama, A. Matsuura, S. Kamosida, A. Miyauchi, K. Watanabe: "Carcinoembryonic antigen and nonspecific crossreacting antigen in medullary carcinoma of the thyroid." Acta Pathol Jpn. 40. 261-266 (1991)

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Published: 1993-03-16  

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