1992 Fiscal Year Final Research Report Summary
CHOLESTEROL SYNTHESIS IN CHOLESTEATOMA
Project/Area Number |
03670822
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Research Category |
Grant-in-Aid for General Scientific Research (C)
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Allocation Type | Single-year Grants |
Research Field |
Otorhinolaryngology
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Research Institution | THE JIKEI UNIVERSITY SCHOOL OF MEDICINE |
Principal Investigator |
SUGITA Takafumi THE JIKEI UNIVERSITY SCHOOL OF MEDICINE OTOLARYNGOLOGY, LECTURER, 医学部, 講師 (50133393)
|
Co-Investigator(Kenkyū-buntansha) |
HAYASHI Naruhiko THE JIKEI UNIVERSITY SCHOOL OF MEDICINE OTOLARYNGOLOGY, ASSISTANT, 医学部, 助手 (40173017)
|
Project Period (FY) |
1991 – 1992
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Keywords | CHOLESTEATOMA / TISSUE CULTURE / CHOLESTEROL SYNTHESIS |
Research Abstract |
At the present time, the origin of the cholesterol in the cholesteatoma is still uncertain. In this study, we cultured the tissues of cholesteatoma and added C-acetic acid and H-leucine to measure the synthesis of cholesterol in cholesteatoma in vitro. Acetic acid and leucine are one of the precursors of cholesterol synthesis.The result showed that the cholesterol derived from acetate did not exist in cholesteatoma tissue. On the other hand, the cholesterol derived from leucine exists in cholesteatoma.This result suggests that the cholesterol in cholesteatoma is synthesized in the tissue in vivo.
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