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1992 Fiscal Year Final Research Report Summary

Study on quantification of radiation-induced aging by linear model

Research Project

Project/Area Number 03671085
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 医学一般
Research InstitutionNagasaki University

Principal Investigator

KONDO Hisayoshi  Scientific Data Center for the A-bomb Disaster Nagasaki University School of Medicine, Assistant, 医学部・原爆資料センター, 助手 (00170431)

Co-Investigator(Kenkyū-buntansha) SHIMAZAKI Tatsuya  Department of Radiation Biophysics Nagasaki University School of Medicine, Techn, 医学部・原研放射, 教務員
MINE Mariko  Scientific Data Center for the A-bomb Disaster Nagasaki University School of Med, 医学部・原爆資料センター, 講師 (00108292)
ISEKI Masachika  Scientific Data Center for the A-bomb Disaster Nagasaki University School of Med, 医学部・原爆資料センター, 助手 (50176252)
KISHIKAWA Masao  Scientific Data Center for the A-bomb Disaster Nagasaki University School of Med, 医学部・原爆資料センター, 助教授 (80112374)
OKUMURA Yutaka  Scientific Data Center for the A-bomb Disaster Nagasaki University School of Med, 医学部・原爆資料センター, 教授 (00073130)
Project Period (FY) 1991 – 1992
Keywordsradiation-induced aging / serum components / time series changes / accelerated aging / senescence accelerated mouse
Research Abstract

Radiation-induced aging on five serum components which were total cholesterol, inorganic phosphorus, albumin, glucose and GOT and considered to depend on age were measured sequentially in SAM-P/1 which was the senescence accelerated mouse.
The regression equations of each observed value on age of week were calculated by each groups whose radiation dose were 0, 2, 3 and 4 Gy. The equality and dose-dependency of each regression coefficients were tested between groups.
In inorganic phosphorus, radiation-induced aging was observed, and the type of aging was the accelerated aging, which changed the slant in regression line.
In total cholesterol, albumin, glucose and GOT, radiation-induced aging were not observed.
From these results, it was considered that the radiation-induced aging was different by items.

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Published: 1994-03-24  

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