1994 Fiscal Year Final Research Report Summary
Clinical and Experimental Study on the pathology of olfactory epithelial disorder.
Project/Area Number |
04671048
|
Research Category |
Grant-in-Aid for General Scientific Research (C)
|
Allocation Type | Single-year Grants |
Research Field |
Otorhinolaryngology
|
Research Institution | OSAKA CITY UNIVERSITY |
Principal Investigator |
AIBA Tsunemasa Osaka City University, Medicine, Lecturer, 医学部, 講師 (10192840)
|
Project Period (FY) |
1992 – 1994
|
Keywords | Olfactory epithelium / Common cold / Virus / Trace metals / Immunohistochemistry / Nerve growth factor / Aging / Regeneration |
Research Abstract |
(1)Clinical features of olfactory disorder following common cold is as follows : 1.It occurs most frequently in middle-aged women, suggesting a relationship between olfaction and sex hormone. 2.It is often accompanied by abnormal smell perception. (2)An analysis of the monthly incidence of the common cold as a trigger of olfactory disorder revealed that it occurred mostly in spring and summer. Therefore para-influenza virus, enterovirus group, adenovirus are rather more likely to be the causative agents of the disorder. Serological study suggested the relationship between the disorder and para-influenza virus type 3. (3)Plasma levels of biological trace metals in patients with olfactory disorder in any etiology were investigated. The total balance of minerals and other nutritional elements is important in the treatment of olfactory disorders. In cases of olfactory epithelial disorder with zinc deficiency, internal use of zinc sulfate was effective. (4)NGF and NGF receptor were detected in the olfactory epithelium of young and mature rats with an immunohistochemical technique. NGF plays a role in the maintenance and regeneration of olfactory nerve cells. (5)The decrease of the area of olfactory epithelium depends on the respiratory epithelization on the margin of it. The regeneration ability of olfactory nerve cell decrease in the aged animals.
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Research Products
(10 results)