1993 Fiscal Year Annual Research Report

生物機能が求める多元金属錯体反応系の研究

Research Project

Project/Area Number	05353003
Research Institution	Nagoya University
Principal Investigator	山内脩名古屋大学, 理学部, 教授 (70029643)
Co-Investigator(Kenkyū-buntansha)	桜井弘京都薬科大学, 薬学部, 教授 (30065916) 木村栄一広島大学, 医学部, 教授 (30034010) 大川尚士九州大学, 理学部, 教授 (00037219) 鈴木晋一郎大阪大学, 教養部, 教授 (70116052) 上山憲一大阪大学, 理学部, 教授 (80093376)
Keywords	多元金属錯体 / 生物無機化学 / 生命金属元素 / 超機能システム / 環境と医療 / 反応制御 / 高次構造 / 化学的構築
Research Abstract	金属酵素など,種々の金属錯体を含む生体内反応系を解明し,化学反応系の構築とその生物機能を調べることを目指して,次の3項目に関する研究を企画し,調査を行った:1)多元金属錯体反応系の化学的構築,2)多元金属錯体反応系の分子配列,3)生体反応系の構造と機能発現メカニズム.調査の結果,生体系の大きな特徴は,金属酵素などが物質の交換経路上あるいは電子伝達経路上に有機的に配列され,反応が精密にコントロールされていることであり,このことが生体内反応の方向性と機能を支配しているため,生命現象の解明には個々の反応を統一し,方向性を有する反応系を構築することが求められているとの結論に達した.さらにこの方向で,現在進行中の生物無機化学研究に続く次代の生物機化学を目指して,生物機能が必要とする多成分から成る金属錯体系の研究を展開すべく,重点領域研究を推進するべしとの一致を見た.そこで,さらに(1)生体反応系の解明,(2)化学反応系の構築,(3)分子配列,(4)生物機能,の各面からの研究を企画し,研究対象,方法論,意義などに関して調査を行って,全体としての研究体系を検討した.本研究結果をふまえて,平成7年度発足重点領域「生命金属元素の超機能システム」として申請を行なった.本申請では,A)環境と医療における超機能システム,B)超機能を支える反応制御,C)超機能が求める高次構造,D)超機能システムの化学的構築,の各研究項目を柱として,生物機能と化学機能とを結びつけると共に,医学や地球環境保全に貢献することをも目指している.

Research Products
(13 results)

All Other

All Publications (13 results)

[Publications] H.Masuda: "Structures and Stabilities of Ternary Copper(II) Complexes Containing an Acidic and a Basic Amino Acid.Evidence for Arginine Side Chain Involvement in Inter-molecular Interactions and Its Biological Implication" Inorg.Chem.32. 1111-1118 (1993)
[Publications] Osamu Yamauchi: "Ternary Metal(II) Complexes with Tyrosine-Containing Dipeptides.Structures of Copper(II) and Palladium(II) Complexes Involving L-Tyrosylglycine and Stabilization of Copper(II) Complexes Due to Intramolecular Aromatic Ring Stacking." Inorg.Chem.32. 4951-4959 (1993)
[Publications] Akira Odani: "Structures and Properties of Temary Copper(II) Complexes Involving a Halogen Substituted Pheny-lalanine and 2,2'-Bipyridine.Intermolecular Interactions between Halo and Organic Groups." Bull.Chem.Soc.Jpn.67. 131-137 (1994)
[Publications] Akira Odani: "Spectroscopic Evidence for the Redox Reaction between Copper(II) and a Pterin Cofactor Model,6,7-Dimethyl-5,6,7,8-tetrahydropterin." Chem.Lett.385-388 (1994)
[Publications] L.Lomozik: "Spectroscopic studies on complex formation and noncovalent interactions in ter-nary palladium(II) systems involving spermidine and 2,3-diaminopropionate of 2,4-diaminobutyrate." Inorg.Chim.Acta. 219. 107-114 (1994)
[Publications] S.Ozawa: "Preparation and Characterization of Oxoiron(IV) Chlorin Complexes as the First Models for a Reaction Intermediate in the Catalytic Cycle of Cyto-chrome d." J.Am.Chem.Soc.116. 634-641 (1994)
[Publications] H.Sakiyama: "Dinuclear Manganese(II) Complexes of 2,6-Bis [2-(dialkylamino)-ethylimino-methyl]-4-methylphenolate(1-):Synthesis,Structure,and Magnetism." J.Chem.Soc.Dalton.591-595 (1993)
[Publications] H.Sakiyama: "A Functional Model of Manganese Catalase.Mass Spectrometric and Visible Spectral Evidence for {Mn^<IV>(=0)}_2 and Mn^<II> Mn^<IV>(=0) Intermediates." J.Chem.Soc.Chem.Commun.882-884 (1993)
[Publications] S.Itoh: "Physicochemical Properties of 2-Methylthio-4-methylphenol,a Model Com-pound of the Novel Cofactor of Galactose Oxidase." Chem.Lett.12. 2099-2102 (1993)
[Publications] N.Nakamura: "Structure of a Tripotassium Pyrroloquinoline Quinone Salt." Acta Cryst.2093-2095 (1993)
[Publications] Y.Nakao: "Preparation and Properties of the Dinuclear Copper(II) Complexes Bridged by an Alkoxo and an Exogenous Bridging Ligand." Bull.Chem.Soc.Jpn.67. 260-262 (1994)
[Publications] T.Kohzuma: "Direct Electrochemistry of Nitrite Reductase from Achromobacter cycloclastes IAM 1013." Bull.Chem.Soc.Jpn.138-143 (1994)
[Publications] K.D.Karlin: "Bioinorganic Chemistry of Copper" Copper(II)-Pteridine Chemistry.Structures,Properties,and Phenylalanine Hydroxylase Models., (1993)

1993 Fiscal Year Annual Research Report

生物機能が求める多元金属錯体反応系の研究

Principal Investigator

山内 脩 名古屋大学, 理学部, 教授 (70029643)

Research Products

[Publications] H.Masuda: "Structures and Stabilities of Ternary Copper(II) Complexes Containing an Acidic and a Basic Amino Acid.Evidence for Arginine Side Chain Involvement in Inter-molecular Interactions and Its Biological Implication" Inorg.Chem.32. 1111-1118 (1993)

[Publications] Osamu Yamauchi: "Ternary Metal(II) Complexes with Tyrosine-Containing Dipeptides.Structures of Copper(II) and Palladium(II) Complexes Involving L-Tyrosylglycine and Stabilization of Copper(II) Complexes Due to Intramolecular Aromatic Ring Stacking." Inorg.Chem.32. 4951-4959 (1993)

[Publications] Akira Odani: "Structures and Properties of Temary Copper(II) Complexes Involving a Halogen Substituted Pheny-lalanine and 2,2'-Bipyridine.Intermolecular Interactions between Halo and Organic Groups." Bull.Chem.Soc.Jpn.67. 131-137 (1994)

[Publications] Akira Odani: "Spectroscopic Evidence for the Redox Reaction between Copper(II) and a Pterin Cofactor Model,6,7-Dimethyl-5,6,7,8-tetrahydropterin." Chem.Lett.385-388 (1994)

[Publications] L.Lomozik: "Spectroscopic studies on complex formation and noncovalent interactions in ter-nary palladium(II) systems involving spermidine and 2,3-diaminopropionate of 2,4-diaminobutyrate." Inorg.Chim.Acta. 219. 107-114 (1994)

[Publications] S.Ozawa: "Preparation and Characterization of Oxoiron(IV) Chlorin Complexes as the First Models for a Reaction Intermediate in the Catalytic Cycle of Cyto-chrome d." J.Am.Chem.Soc.116. 634-641 (1994)

[Publications] H.Sakiyama: "Dinuclear Manganese(II) Complexes of 2,6-Bis [2-(dialkylamino)-ethylimino-methyl]-4-methylphenolate(1-):Synthesis,Structure,and Magnetism." J.Chem.Soc.Dalton.591-595 (1993)

[Publications] H.Sakiyama: "A Functional Model of Manganese Catalase.Mass Spectrometric and Visible Spectral Evidence for {Mn^<IV>(=0)}_2 and Mn^<II> Mn^<IV>(=0) Intermediates." J.Chem.Soc.Chem.Commun.882-884 (1993)

[Publications] S.Itoh: "Physicochemical Properties of 2-Methylthio-4-methylphenol,a Model Com-pound of the Novel Cofactor of Galactose Oxidase." Chem.Lett.12. 2099-2102 (1993)

[Publications] N.Nakamura: "Structure of a Tripotassium Pyrroloquinoline Quinone Salt." Acta Cryst.2093-2095 (1993)

[Publications] Y.Nakao: "Preparation and Properties of the Dinuclear Copper(II) Complexes Bridged by an Alkoxo and an Exogenous Bridging Ligand." Bull.Chem.Soc.Jpn.67. 260-262 (1994)

[Publications] T.Kohzuma: "Direct Electrochemistry of Nitrite Reductase from Achromobacter cycloclastes IAM 1013." Bull.Chem.Soc.Jpn.138-143 (1994)

[Publications] K.D.Karlin: "Bioinorganic Chemistry of Copper" Copper(II)-Pteridine Chemistry.Structures,Properties,and Phenylalanine Hydroxylase Models., (1993)

山内脩名古屋大学, 理学部, 教授 (70029643)