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1995 Fiscal Year Final Research Report Summary

Difference in the properties of contraction in vassular and intestinal smooth mscles

Research Project

Project/Area Number 05404015
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionThe University of Tokyo

Principal Investigator

KARAKI Hideaki  The University of Tokyo, Professor, 農学部, 教授 (60011912)

Co-Investigator(Kenkyū-buntansha) TSUBONE Hirokazu  The University of Tokyo, Associate Professor, 農学部, 助手 (30142095)
SUGANO Shigeru  The University of Tokyo, Professor, 農学部, 助教授 (70111482)
SAITO Minori  The University of Tokyo, Assistant Professor, 農学部, 助手 (70192359)
OZAKI Hiroshi  The University of Tokyo, Associate Professor, 農学部, 助教授 (30134505)
Project Period (FY) 1993 – 1995
KeywordsSmooth Muscle / Phasic Muscle / Tonic Muscle / Cytosolic Ca level / Platelet activating factor / Endothelin
Research Abstract

In some smooth muscles, stimulation by elevated external K^+ concentration or receptor agonists increases the amplitude of phasic contraction, with little, if any, elevation in tone. These muscles have been classified as "phasic" type. This type contrasts with "tonic" type which maintain force generation over time without visible rhythmic fluctuations. Mechanism responsible for these differences has not been examined except to speculate that differences in membrane electrical activities may be responsible for. The major emphasis of this study was to characterize the physiological and pharmacological properties between these smooth muscle subtypes. In this study, we have revealed 1) role of PAF in phasic muscle, 2) subtypes of endothelin receptors in phasic and tonic muscles, 3) subtypes of purinoceptors in tonic muscle, 4) role of protein kinase C in phasic and tonic muscle, etc.

  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Hori.M: "Different Pathways of Calcium sensitization activated by receptor agonists and phovbol esters in vascular smooth muscle." British J. Pharmacology. 110. 1527-1531 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kitajima,S: "The Effects of ATP and αβ-methylene-ATP on cytosolic Ca^<2+> level and force in isolated rat aovta." British J. Pharmacology. 110. 263-268 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mitsui,M: "Contractile and relaxant effects of phorbol ester in the intestinal smooth muscle of guinea pig taenic coeci" British J. Pharmacology. 109. 229-233 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ozaki,H: "Ca^<2+> regulation of the contractile apparatus in canine gastric smooth muscle." J Physiology. 460. 33-50 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ozaki,H: "Different Ca^<2+> sensitivity in phasic and tonic types of smooth muscles" Biol. Signals. 2. 253-262 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kitajima S: "Role of different subtypes of P_2 prinoceptor on cytosolic Ca^<2+> levels in rat aortic smmoth muscle." European J. Pharmacology. 266. 263-267 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hori, M: "Defferent pathways of calcium sensitization activated by receptor agonists and phorbol esters in vascular smooth muscle" Br.J.Pharmacol. 110. 1527-1531 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitajima, S: "The effects of ATP and alpha.beta.methylene.ATP on cytosolic Ca^<2+> level and force in siolated rat aorta" Br.J.Pharmacol. 110. 263-268 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mitsui, M: "Contractile and relaxant effects of phorbol ester in the intestinal smooth muscle of guinea pig taenia caeci" Br.J.Pharmacol. 109. 229-233 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ozaki H: "Ca^<2+> regulation of the contractile apparatus in canine gastivic smooth muscle" J.Physiol. 460. 33-50 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ozaki H: "Different Ca^+-sensitivity in phasic and tonic types of smooth muscle" Biol.Signals. 2. 253-262 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitajima S: "Role of different subtypes of P_2 purinoceptor on cytosolic Ca^<2+> levels in rat aortic smooth muscle" Eur.J.Pharmacol. 266. 263-267 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] ABE,F: "Calcium compartments in vascular smooth muscle cells as detected by aeguorin signal" Br.J.Pharmacol. 116. 3000-3004 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kim, BK: "Increased sensitivity of rat myometrium to the contractile effect of platelet activating factor before delive" Br.J.Pharmacol. 115. 1211-1214 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sudiarrwa SA: "Role of protein kinase C on the endothelin induced contraction in the rabbit saphenous vein" Eur.J.Pharmacol. 294. 261-269 (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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