1995 Fiscal Year Final Research Report Summary
A study on pathophysiology of circulatory dysfunction in immature fetuses by extrauterine fetal incubation
| Project/Area Number |
05454344
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | UNIVERSITY OF TOKYO |
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Principal Investigator |
OKAI Takashi University of Tokyo, Dept.of Obstetrics and Gynecology, Associate Professor, 医学部(病), 助教授 (40126016)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Kouichi University of Tokyo, Dept.of Obstetrics and Gynecology, Lecturer, 医学部(病), 助手 (10262015)
RYO Eiji University of Tokyo, Dept.of Obstetrics and Gynecology, Lecturer, 医学部(病), 助手 (30221683)
FUJII Tomoyuki University of Tokyo, Dept.of Obstetrics and Gynecology, Lecturer, 医学部(病), 助手 (40209010)
UNNO Nobuya University of Tokyo, Dept.of Obstetrics and Gynecology, Lecturer, 医学部(病), 助手 (90193979)
KOZUMA Shiro University of Tokyo, Dept.of Obstetrics and Gynecology, Lecturer, 医学部(病), 助手 (10272569)
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| Project Period (FY) |
1993 – 1995
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| Keywords | artificial placenta / fetus / cerebral blood flow / colored microsphere / oxygen consumption / ECMO |
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| Research Abstract |
1. The condition of isolated goat fetuses with umibilical arteriovenous extracorporeal membrane oxygenation was investigated. (1) Umbilical arteriovenous extracorporeal membrane oxygenation enabled isolated goat fetuses to survive for three weeks. (2) It was confirmed that fetal circulation was maintained with the patent ductus arteriosus during the extrauterine incubation period. (3) The fetuses maintained stable circlatory and respiratory paramaters after the postoperative period. (4) Oxygen consumption in the incubated fetuses was almost the same as the level in the intrauterine fetuses.
2. Effects of repeated umbilical cord occlusion on brain circulation in fetal goats were investigated by colored microsphere technique. (1) The blood flow to the cerebral cortex, white matter, cerebellum and medulla increased by 200-300% respectively during umbilical cord occlusion. (2) The regional blood flow in the brain increased further after the release of cord occlusion. However, it tended to decrease with the repetition of cord occlusion.
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[Publications] Unno N,Kuwabara Y,Narumiya-Takikawa Y,Takechi K,Masuda H,Ogami Y,Tsushima R,Sakai M,Baba K,Okai T,Kozuma S,Taketani Y: "Development of an artificail placenta : Endocrine responses of goat fetuses during long-term extrauterine incubation with umbilical arteriovenous extracoporeal membrane oxygenation." Endocrine Journal. 41 (Suppl). S69-S76 (1994)
Description
「研究成果報告書概要(欧文)」より
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