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1995 Fiscal Year Final Research Report Summary

Physiological role of the ascending monoaminergic system in hypothalamo-hypophysial responses to emotional stress

Research Project

Project/Area Number 05454675
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research InstitutionJichi Medical School

Principal Investigator

YAGI Kinji  Department of Physiology, Jichi Medical School, Professor, 医学部, 教授 (70048974)

Project Period (FY) 1993 – 1995
KeywordsVasopressin / Fear stress / Anxiety stress / Dopamine / Histamine / Noradrenaline / Benzodiazepine / Serotonin
Research Abstract

Effects of monoaminergic receptor antagonists or a benzodiazepine were studied on neuroendocrine responses to fear stimuli of anxiety-producing novel stimuli in male Wistar rats.
1.Dopaminergic D1 receptors were found to mediate facilitatory vasopressin response to noxious stimuli but not the suppressive vasopressin response to conditioned fear stimuli.
2.Anxiogenic novel environmental stimuli were shown to suppress vasopressin secretion.
3.Histaminergic H2 receptors were shown to mediate the suppressive vasopressin response to novel stimuli and to inhibit, in an activity-dependent manner, the facilitatory oxytocin response to the stimuli.
4.The noradrenergic system was demonstrated to mediate the responses in vasopressin, oxytocin and prolactin secretion to conditioned fear stimuli but not to the responses to unconditioned fear stimuli or anxiogenic novel environmental stimuli.
5.Chlordiazepoxide, one of the benzodiazepines which are known to ameliorate an anxiety state as a result of modulating noradrenergic neuron activity, was found to block the responses in vasopressin and oxytocin secretion to unconditioned or conditioned fear stimuli but not the responses to anxiety-producing novel environmental stimuli.
6.Serotonergic 5-HT_<1A> receptors were demonstrated to be involved in the vasopressin and oxytocin responses to conditioned fear stimuli but not to novel stimuli.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Yagi,K: "Effects of a histamine H2-receptor antagonist,ranitdine on the vasopressin and oxytocin responses to novelty stress in the rat." Neurosci Res. 19. 357-364 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yagi,K: "Suppressive vasopressin reponse to emotional stress and the neuroactive substances involved (in Japanese)" Brain Sci Mental Disorders. 5. 127-136 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yagi,K and Onaka,T: "Chlordiazepoxide discriminates between the neural circuits mediating neuroendocrine responses to fear-and anxiety-producing stimuli in the rat." Neurosci Res. 24. 151-158 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yagi,K and Onaka,T: "A benzodiazepine,chlordiazepoxide,blocks vasopressin and oxytocin release after footshocks but not osmotic stmulus in the rat." Neurosci Letters. 203. 49-52 (1966)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Onaka,T and Yagi,K: "Norepinephrine deletion impairs neuroendocrine responses to fear not novel environmental stimuli in the rat." Brain Res. in the press. (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Onaka,T and Yagi,K: "A selective role of brainstem noradrenergic neurons in oxytocin release from the neurohypophysis following noxious stimuli in the rat." Neurosci Res. in the press. (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yagi, K and Onaka, T: "Suppressive vasopressin response to emotional stress : the neuroactive substance that may be involved." Ann NY Acad Sci. 689. 685-688 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Onaka T and Yagi, K: "Effects of novelty stress on vasopressin and oxytocin secretion by the pituitary in the rat." J Neuroendocrinol. 5. 365-369 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yagi, K: "Effects of a histamine H2-receptor antagonist, ranitidine on the vasopressin and oxytocin responses to novelty stress in the rat." Neurosci Res. 19. 357-364 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yagi, K: "Suppressive vasopressin response to emotional stress and the neuroactive substances involved" Brain Sci Mental Disorders. 5 (in Japanese). 127-136 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yagi, K and Onaka, T: "Chlordiazepoxide discriminates between the neural circuits mediating neuroendocrine responses to fear- and anxiety-producing stimuli in the rat." Neurosci Res. 24. 151-158 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yagi, K and Onaka, T: "A benzodiazepine, chlordiazepoxide, blocks vasopressin and oxytocin release after footshocks but not osmotic stimulus in the rat." Neurosci Letters. 203. 49-52 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Onaka, T and Yagi, K: "Norepinephrine deletion impairs neuroendocrine responses to fear but not novel environmental stimuli in the rat." Brain Res. (in the press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Onaka, T and Yagi, K: "A selective role of brainstem noradrenergic neurons in oxytocin release from the neurohypophysis following noxious stimuli in the rat." Neurosci Res. (in the press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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