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1994 Fiscal Year Final Research Report Summary

Molecular biological study of lymphocytic stem cell leukemia

Research Project

Project/Area Number 05670937
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Hematology
Research InstitutionFukuoka University

Principal Investigator

KIMURA Nobuhiro  Fukuoka University, School of Medicine.The First Dep.of Internal Medicine, Associate Professor, 医学部・第一内科, 講師 (40136445)

Co-Investigator(Kenkyū-buntansha) KIKUCHI Masahiro  School of Medicine, The First Dep.of Pathology, Professor, 医学部・第一病理, 教授 (80078774)
Project Period (FY) 1993 – 1994
KeywordsDdelta2 (D) Jdelta1 / cytoplasmic CD3 / CD7+ stem cell leukemia / NK cell / Epstein Barr virus / T-precursor leukemia
Research Abstract

We analyzed the immunoassociated genes, specially T-cell receptor(TcR)delta chain gene, of sixteen patients with CD7+stem cell leukemia as lymphocytic stem cell leukemia, and of nine patients with sinonasal malignant lymphoma.
In 1993, we reported that the DDJdelta rearrangement are frequently shown in the patients with CD7+ stem cell leukemia and occur more earlier stage than that of expression of cytoplasmic CD3epsilon in T-cell development. These findings indicate DDJdelta to be a marker of T-lineage stem cell, and suggest that TcRdelta gene rearrangement occur as following ; DD*DDJ*VDDJ.
In 1994, we documented that five out of sixteen patients with CD7+ stem cell leukemia, showed the specific clinical, immunophenotypic and immunogenotypic characteristics. We reported this subgroup as T-precursor leukemia/lumphoma. The T-precursor leukemia/lymphoma has some characteristics as following ; 1) on phenotypic examination, the phenotypes of blast cells correspond to those of early T cells between prothymocyte stage I and II,2) on the clinical feature at diagnosis, without blast cells in peripheral blood, with thymoma (4/5 cases) and lymphoadenopaty (4/5 cases) ; these patients achieved complete remission (5/5) but had relapse (4/5) , indicating transformation to mixed type (4/4, T/B/M-2 cases, T/M-2 cases) , 3) on immunogenotypic examination, the presence of the common Ddelta2 (D) Jdelta1. The more intensive chemotherapy including the stem cell transplantation should be considered to alter the poor prognosis of T-precursor leukemia.
In nine patients with sinonasal malignant lymphoma, which is generally considered to be T-cell lineage, 8 cases were suggested to be originated from Natural killer (NK) cell, which in many patients correspond to fetal NK cell type with cCD3. This finding suggests the presence of common precursor to both NK cell and T-cell. The lymphoma cells of all nine patients have the monoclonal integration of Epstein Barr virus.

  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Katsuno M. , et al.: "CD7+stem cell leukemia/lymphoma:Features of a subgroup without circulating blast cells" Cancer. 72. 99-104 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akashi K. , Mizuno S. , Harada M. , Kimura N. et al. :"T lymphoid/myeloid bilineal crisis in chronic myelogenous leukemia" Exp. Hematol.21. 743-748 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimamoto T. , et al.: "Clinical and Biologic characteristics of CD7^+ acute myeloid leukemia:Our experience and literature review" Cancer Genet Cytogenet. 73. 69-74 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzumiya J. , Takeshita M. , Kimura N. et al. :"Expression of adult and fetal natural killer cell markers in sinonasal lymphomas" Blood. 83. 2255-2260 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimamoto T. , Ohyashiki JH. , Ohyasiki K. , Kawakubo K. , Kimura N. et al. :"GATA-1, GATA-2, and stem cell leukemia gene expression in acute myeloid leukemia" Leukemia. 8. 1176-1180 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimura N. , Akiyoshi T. , Uchida T et al.: "High prevalence of T-cell receptor Ddelta2 (Ddelta) Jdelta rearrangement in CD7-positive stem cell leukemia/lymphoma" submitting to Leukemia.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimura N., Suzumiya J., Akiyoshi T.et al.: "Rearrangements of T-cell receptor and immunoglobulin genes in Hodgkin's disease ; Polyclonal rearranged bands and HTLV-I integration in mixed cellularity subtype" Med.Bull Fukuoka Univ.20 (2). 79-88 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tachibana K., Kimura N., Okumura M.et al.: "Enhancement of cell killing of HL-60 cells by ultrasound in the presence of the photosensitizing drug Photofrin II" Cancer Letters. 72. 195-199 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Katsuno M., Abe Y., Taguchi F., Yufu Y., Sadamura S., Goto T., Takatsuki H., Nishimura J., Hirata J., Akiyoshi T., Kimura N., Nawata H.: "CD7+ stem cell leukemia/lymphoma : Features of a subgroup without circulating blast cells" Cancer. 72 (1). 99-104 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohshima K., Kikuchi M., Kobari S., Masuda Y., Eguchi F., Kimura N.: "Amplified bcl-2/JH rearrangements in reactive lymphoadenopathy" Virchows Archiv (B) : Cell Pathology. 63. 197-198 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hara T., Matsumoto T., Mizuno Y., Nishizaki M., Ueda K., Motooka M., Kimura N.et al.: "Peripheral expansion of gammadelta T cell receptor-positive cells in a patients with Crohn's disease" Acta Paediatrica Japonica. 38. 45-48 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawakubo K., Ohyashiki JH., Ohyashiki K., Iwabuchi A., Kimura N.et al.: "Acute myeloid leukemia with concomitant expression of T-/B-lymphoid antigens and immunogenotypic alterations exhibiting t (7 ; 12)(q32 ; q24) : A case report" Leukemia. 7 (6). 909-911 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akashi K., Mizuno S., Harada M., Kimura N.et al.: "T lymphoid/myeloid bilineal crisis in chronic myelogenous leukemia" Exp.Hematol.21. 743-748 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohyashiki JH., Ohyashiki K., Kawakubo K., Fujimura T., Shimamoto T., Nakazawa S., Kimura N., Toyama K.: "Comparison between immunophenotypic findings in de novo AML and AML post MDS" Leukemia. 7 (11). 1747-1751 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohshima K., Kikuchi M., Yoneda S., Kobari S., Sumiyoshi Y., Takeshita M.and Kimura N.: "Restriction of T-cell receptor variable region in lymph nodes of adult T-cell leukemia/lymphoma" Hematol Oncol. 11. 147-154 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimamoto T., Ohyashiki JH., Ohyashiki K., Kawakubo K., Inatomi Y., Fujieda H., Nakazawa S., Kimura N., Miyauchi J., Toyama K.: "Clinical and Biologic characteristics of CD7^+ acute myeloid leukemia : Our experience and literature review" Cancer Genet Cytogenet. 73. 69-74 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzumiya J., Takeshita M., Kimura N.et al.: "Expression of adult and fetal natural killer cell markers in sinonasal lymphomas" Blood. 83(8). 2255-2260 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshida T., Suzumiya J., Katakami H., Kimura N.et al.: "Hypercalcemia caused by PTH-rp associated with metastasis from the urinary bladder carcinoma : An autopsied case" J Intemal Med. 33 (11). 673-676 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimamoto T., Ohyashiki JH., Ohyashiki K., Kawakubo K., Kimura N.et al.: "GATA-1, GATA-2, and stem cell leukemia gene expression in acute myeloid leukemia" Leukemia. 8(7). 1176-1180 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura N., Akiyoshi T., Uchida T,et al.: "High prevalence of T-cell receptor Ddelta2 (Ddelta) Jdelta rearrangement in CD7-positive stem cell leukemia/lymphoma" submitting to Leukemia.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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