1995 Fiscal Year Final Research Report Summary
Preoperative assessment for malignant behavior of upper gastrointestinal tract
Project/Area Number |
05671076
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Research Category |
Grant-in-Aid for General Scientific Research (C)
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Allocation Type | Single-year Grants |
Research Field |
Digestive surgery
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Research Institution | KAGOSHIMA UNIVERSITY |
Principal Investigator |
AIKOU Takashi Kagoshima University Faculty of Medicine Professor, 医学部, 教授 (60117471)
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Co-Investigator(Kenkyū-buntansha) |
BABA Masamichi Kagoshima University University Hospital Assistant Professor, 医学部附属病院, 講師 (60198950)
TANABE Gen Kagoshima University University Hospital Research Associate, 医学部附属病院, 助手 (60207157)
NATSUGOE Shoji Kagoshima University University Hospital Research Associate, 医学部附属病院, 助手 (70237577)
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Project Period (FY) |
1993 – 1995
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Keywords | Carcinoma of the upper gastrointestinal tract / Malignant behavior of the carcinoma / Metastasis / Cell adhesion molecle / Desmosome |
Research Abstract |
Desmosomes are intercellular junctions which play an important role in epithelial cell adhesion. We reported a decrease in number of desmosomes in esophageal cancer cells as shown by electron microscopic study. Desmoglein I (DGI) is a major component of the desmosomal membrane core that plays an important role in epitherial cell adhesion. Normal squamous epitherial cells strongly expressed DGI at their cell-cell boundaries. According to the intensity and pattern of DGI expression, the cancerous tissues were divided into three groups : DGI (++), DGI (+), and DGI (-). DGI (+) or DGI (-) tumors had lymph node metastases more frequently than DGI (++). A good inverse correlation between DGI expression and tumor invasion, lymph node metastasis, lymphatic invasion and vessel invasion was observed. DGI expression in metastatic lymph nodes was the same or of less intensity, than in the primary tumor. Therefore, reduction or loss of DGI expression may promote lymph node metastases. Thorombomodul
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in (TM) is thorombin receptor that identified originally on the endothelium and acts a natural anticoagulant. TM was immunohistochemically expressed in the squamous epithelium mainly at the intercellular bridges. The carcinoma tissues expressed TM mainly at the cell-cell boundaries and in the cytoplasm. When TM expression was compared between the primary and metastatic lesions, TM expression was far fewer in the metastatic lesions than in the primary tumors. The reduction of TM expression seems to play an important role in the metastatic process. In the patinets with gastric carcinoma, a down-regulation of DGI expression and lymph node metastasis, lymphatic invasion and the number of lymph node metastasis. A close relationship between DGI expression and lymph node metastasis was found, compared with C-erbB2, p53, FH6 and PCNA.Furthermore, survival rate of patients with HLA-DR positive cells or with many S-100 protein positive dendritic cells was significantly better than that of the other patients. These results may provide us with some important infomations for malignant behavior of the upper gastrointestinal tract. Less
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Research Products
(15 results)
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[Publications] Shoji Natsugoe, Mituhisa Sagara, Mario Shimada, Toru Kumanohoso, Shimada, Toru Kumanohoso, Kazunobu Tokuda, Daisuke Wakamatus, Yoshihisa Tezuka, Chikara Kusano, Heiji Yoshinaka, Masamichi Baba, Toshitaka Fukumoto, Takashi Aikou: "Expression of desmoglein I cell adhesion molecule in primary tumors and metastatic lymph nodes of esophageal cancer" International Journal of Oncology. 6. 345-348 (1995)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Yoshihisa Tezuka, Suguru Yonezawa, Ikuro Maruyama, Yoshihumi Matsushita, Takeshi Shimizu, Hiroya Obama, Mistuhisa Sagara, Kazusada Shirao, Chikara Kusano, Shoji Natsugoe, Heiji Yoshinaka, Masamichi, Baba, Toshitaka Fukumoto, Takashi Aikou, Eiichi Sato: "Expression of thorombomodulin in esophageal squamous cell carcinoma carcinoma and its relationship to lymph node metastasis" Cancer Research. 55. 4196-4200
Description
「研究成果報告書概要(欧文)」より