1995 Fiscal Year Annual Research Report

分子進化学の新展開

Research Project

Project/Area Number	06273103
Research Institution	The Institute of Statistical Mathematics
Principal Investigator	長谷川政美統計数理研究所, 予測制御系, 教授 (60011657)
Co-Investigator(Kenkyū-buntansha)	岡田典弘東京工業大学, 生命理工学部, 教授 (60132982) 宝来聰国立遺伝学研究所, 総合遺伝系, 助教授 (40126157) 植田信太郎東京大学, 大学院・理学研究科, 助教授 (20143357) 五條堀孝国立遺伝学研究所, 生命情報センター, 教授 (50162136) 宮田隆京都大学, 大学院・理学研究科, 教授 (20022692)
Keywords	分子系統樹 / 最尤法 / 微胞子虫 / 組織特異的遺伝子 / 細胞内局在性遺伝子 / エイズウイルス / 人類進化 / トランスポゾン
Research Abstract	蛋白質のアミノ酸置換とDNAの塩基置換に関して現実に即した置換モデルを構築し、最尤法による分子系統樹推定のための方法を開発した。ミトコンドリアをもたない原生生物のうち、微胞子虫がランブル鞭毛虫などのディプロモナスよりも先に高等真核生物に至る系統から分かれたことを示した(長谷川)。組織特異的に発現する遺伝子、シグナル伝達系に関与する遺伝子、および細胞内局在性を示す遺伝子を解析した結果、これらの遺伝子グループはそれぞれ、脊椎動物の進化の初期、多細胞化が起きた時期、および真核生物の進化の初期に急速に多様化したことが分かった。その多様化は、脊椎動物の進化、多細胞化、および細胞内構造の進化と関連していると考えられる(宮田)。分子進化学的な方法により、エイズウイルスがどのように突然変異を蓄積しているかを調べ、未来進化を予測するための手掛かりを得た(五條堀)。旧世界ザルにおける免疫グロブリンCα遺伝子の解析から、この遺伝子が超優性淘汰によって進化してきた可能性のあることを示した(植田)。3人の現代人とチンパンジー、ボノボ、ゴリラ、オランウータンなどの4種の類人猿で、ミトコンドリアDNAの全塩基配列を解析し、人類進化のついての新たな知見を得た(宝来)。転移性遺伝因子(トランスポゾン)を脊椎動物においてはじめてメダカのアルビノ変異のチロシナーゼ遺伝子内に発見し、活性のあるトランスポゾンであることを証明した(堀)。またSINEというトランスポゾンのゲノム中への挿入パターンが、さまざまな系統学的な問題を解くためのマーカーとして役に立つことを示した(岡田)。昆虫細胞内共生微生物が選択的に合成するシンビオニンを近縁な昆虫種で比較した結果、これらの遺伝子の133番目のコドン変異が適応的に選択されており、分子シャペロンに新たな機能が賦与されていることが示唆された(石川)。

Research Products

(63 results)

All Other

All Publications (63 results)

[Publications] Hashimoto,T.et al.: "Phylogenetic place of a mitochondrion-lacking protozoan,Giardia lamblia,inferred from amino acid sequences of elongation factd 2." Mol.Biol.Evol.12. 782-793 (1995)
[Publications] Hashimoto,T.et al.: "Phylogenetic place of kinetoplastid protozoaninferred from a protein phylogeny of elongation factor 1α." Mol.Biochem.Parasitol.70. 181-185 (1995)
[Publications] Adachi,J.,Hasegawa,M.: "Phylogeny of whales : dependence of the inference on species sampling." Mol.Biol.Evol.12. 177-179 (1995)
[Publications] Adachi,J.,Hasegawa,M.: "Improved dating of the human-chimpanzee separation in the mitochondrial DNA tree : heterogeneity among amino acid sites." J.Mol.Evol.40. 622-628 (1995)
[Publications] Adachi,J.,Hasegawa,M.: "Tempo and mode of synonymous substitutions in mitochondrial DNA of primates." Mol.Biol.Evol.13. 200-208 (1996)
[Publications] Nakamura,Y.et al.: "Phylogenetic place of kinetoplastid protozoa inferred from protein phylogenies of elongation factors 1α and 2." J.Biochem.,. 119. 70-79 (1996)
[Publications] Hashimoto,T.,Hasegawa,M.: "Origin and early evolution of eukaryotes inferred from the amino acid sequences of translation elongation factors 1α/Tu and 2/G" Advances in Biophysics. 32. 73-120 (1996)
[Publications] Adachi,J.,Hasegawa,M.: "Model of amino acid substitution in proteins encoded by mitochondrial DNA." J.Mol.Evol.(in press). (1996)
[Publications] Adachi,J.,Hasegawa,M.: "Instability of quartet analyses of molecular sequence data by the maximum likelihood method : The Cetaceal Artiodactyla relationships." Mol.Phyl.Evol.(in press). (1996)
[Publications] Hasegawa,M.,Adachi,J.: "Phylogenetic position of cetaceans relative to artiodactyls : Reanalysis of mitochondrial and nuclear sequences." Mol.Biol.Evol.(in press). (1996)
[Publications] Kuma,K.et al.: "Functional constraints against variations on molecules from tissue level : slowly evoluting brain specific genes demonstrated by protein kinase and immunoglobulin supergene familes." Mol.Biol.Evol.12. 123-130 (1995)
[Publications] Zhang,R,et al.: "Structures of cDNAs encoding the muscle-type and non-muscle-type Isozymes of lamprey fructose bisphosphate aldolases and the evolution of aldolase genes." J.Biochem.117. 545-553 (1995)
[Publications] Kuma,K.et al.: "Phylogenetic position of Dictyostelium inferred from multiple protein data sets." J.Mol.Evol.41. 238-246 (1995)
[Publications] Yokoyama,N.et al.: "A giant nucleopore protein which binds Ran/TC4" Nature. 376. 184-188 (1995)
[Publications] Iwabe,N.,et al.: "Molecular clock for dating of divergence between animal phyla." Jpn.J.Genet.ハ70. 687-692 (1995)
[Publications] Toshima,J.et al.: "Identification and characterization of a novel protein kinase,TESK1,specifically expressed in testicular germ cells." J.Biol.Chem.270. 31331-31337 (1995)
[Publications] Iwabe,N.et al.: "Evolution of gene families and relationship with organisural evolution : Rapid divergence of tissue-specific genes in the early evolution of chordates." Mol.Biol.Evol.(in press). (1996)
[Publications] Geng,L.et al.: "Determination of HLA class II alleles by genotyping in a Manchu population in the northern part of China and its relationship with Han and Japanese populations." Tissue Antigens. 46. 111-116 (1995)
[Publications] Shiina,T.et al.: "Isolation and characterization of cDNA clones for Japanese quail (Coturnic japonica) major histocompatibility complex (Mhc Coja) class I molecules." Immunogenetics. 42. 213-216 (1995)
[Publications] Ohba,K.et al.: "Relationships between serotypes and genotypes of hepatitis B virus : genetic classification of HBV by use of surface genes." Virus Research. 39. 25-34 (1995)
[Publications] Ohba,K.et al.: "Classification of hepatitis C virus into major types and subtypes based on molecular evolutionary analysis." Virus Research. 36. 201-214 (1995)
[Publications] Ikeo,K.et al.: "Different Evolutionary Histories of Kringle and Protease Domains in Serine Proteases-A Typical Example of Domain Evolution." Journal of Mol.Evol.40. 331-336 (1995)
[Publications] Ohba,K.et al.: "Evolutionary relationship of hepatitis C,pesti-,flavi-,plantviruses,and newly discovered GB hepatitis agents" FEBS Letters. 378. 232-234 (1996)
[Publications] Endo,T.et al.: "Large-Scale Search for Genes on Which Positive Selection May Operate." Molecular Biology and Evolution. (in press). (1996)
[Publications] Fumihito,A.et al.: "Monophyletic Origin and Unique Dispersal Patterns of Domestic Fowls." Proc.Natl.Acad.Sci.U.S.A.(in press). (1996)
[Publications] Yamamoto,H.et al.: "Regulatory regions of vertebrate tyrosinase genes : Divergence functional conservation." Proc.Natl.Acad.Sci.U.S.A.(in press). (1996)
[Publications] Oota,H.et al.: "A Genetic Study of 2,000-Year-Old Human Remarns Form Japan Using Mitochondrial DNA Sequeuces" American Journal of Physical Authropology. 98. 133-145 (1995)
[Publications] Watanabe,Y.et al.: "Characterization of Human-specific DNA Sequences obtained by Genome Subtraction" Human Evolution. 10. 63-68 (1995)
[Publications] Watanabe,Y.et al.: "Short Tandem Repeat Polymouphisns in Japanese macaques : tler short repeat lengths and low informativeness" Mammalian Genome. (in press). (1996)
[Publications] Kurosaki,K.et al.: "Sequence Variation Found in the Flaubiy Region of a Triheric Short taudem Repeat at the PLA2 locus" Japanese Journal of Legal Medrine. (in press). (1996)
[Publications] Horai S.et al.: "Recent African origin of modem humans revealed by complete sequences of hominoid mitochondrial DNAs." Proc.Natl.Acad.Sci.USA.92. 532-536 (1995)
[Publications] Umetsu K.et al.: "Orsomucoid phenotyping with monoclonal antibodies : Polymorphic occurrence of OPM1^*Q0 in aboriginal Taiwanese populations." Hum.Hered.45(4). 181-185 (1995)
[Publications] Hammer M.and Horai S.: "Y chromosomal DNA variation and the peopling of Japan." Am.J.Hum.Genet.56. 951-962 (1995)
[Publications] Jin F.et al.: "Genetic polymorphism of ADA in Taiwan aboriginal populations : New ADA variants detected by isoelectric focusing method." Antropol.Sci.103(3). 227-234 (1995)
[Publications] Hayashi S.et al.: "Molecular phylogeny of gibbons inferred from mitochondrial DNA sequences : Preliminary report." J.Mol.Evol.41(3). 359-365 (1995)
[Publications] Horai S.: "Evolution and origins of man : clues from complete sequences of hominoid mitochondrial DNA." Southeast Asian J.Trop.Med.Publ.Health 26 (Suppl.1). 146-154 (1995)
[Publications] Matsuo,M.et al.: "Mollusk gene encoding lysine tRNA (UUU) contain introns." Gene. 165. 249-253 (1995)
[Publications] Kido,Y.et al.: "Evolution of the Active Squence of the Hpa I Short interspersed Elements." J.Mol.Evol.41. 986-995 (1995)
[Publications] Murata,S.et al.: "Details of Retropositional Genome Dynamics That Provide a Rationale for a Generic." Genetics. 142(in press). (1996)
[Publications] Takasaki,N.et al.: "Characterization of Species-Specifically Amplified SINEs in Three Salmonid Species-Chum Salmon,Pink Salmon,and Kokanee." J.Mol.Evol.(in press). (1996)
[Publications] Koga,A.,Inagaki,H.,Bessho,Y.,Hori,H.: "Insertion of a novel transposable element in the tyrosinase gene is responsible for an albino mutation in the medaka fish,Oryzias latipes." Molecular and General Genetics. 249. 400-405 (1995)
[Publications] Fukuda,Y.,Hori,H.et al.: "Significance of the HLA-DQB matching in one-haplotype identical kidney transplant pairs and the matching analysis by the PCR-heteroduplex-polymorphism method" Tissue antigens. 45. 49-56 (1995)
[Publications] Inagaki,Y.,Hori,H.et al.: "Translation of synonymous codons in family boxes by Mycoplasma capricolum tRNAs with unmodified Uridine or adenine at the first anticodon position" Journal of Molecular Biology. 251. 486-492 (1995)
[Publications] Hori,H.,Watanabe,K.I.: "Medakafish homepage on the internet" The Fish Biology Journal MEDAKA. 7. 71-71 (1995)
[Publications] 堀寛,稲垣秀人: "ネズミの腹はなぜ赤い:体色の分子進化" 細胞工学. 14. 999-1006 (1995)
[Publications] H.Charles,H.Ishikawa,P.Nardon: "Presence of a protein specific of endosymbiosis (symbionin) in the weevil Sitophilus" C.R.Acad.Sci.Paris. 318. 35-41 (1995)
[Publications] T.Sasaki,H.Ishikawa,: "Production of essential amino acids from glutamate by mycetocyte symbionts of the pea aphid,Acyrthosiphon pisum." J.Insect Physiol.41. 41-46 (1995)
[Publications] S.Okazaki,H.Ishikawa,H.Fujiwara: "Structural analysis of TRAS 1,a novel family of telomeric repeat associated retrotransposons in the silkworm,B.mori." Molecular and Cellular Biology. 15. 4545-4552 (1995)
[Publications] Iimura,Y,T.Sasaki,T.Fukatsu,H.Ishikawa: "Diminution of intracellular aymbiont of aphid maintained on artificial diet : A morphological study." Zoological Science. 12. 795-799 (1995)
[Publications] T.Sasaki,M.Kawamura,H.Ishikawa: "Nitrogen recycling in the brown planthopper,Nilaparvata lugens : Involvement of yeast-like endosymbionts in uric acid metabolism." J.Insect Physiol.(in press).
[Publications] T.Fukatsu,H.Ishikawa: "Phylogetic position of yeast-like symbiont of Hamiltonaphis styraci (Homoptera,Aphididae) based on 18S rDNA sequence." Insect Biochenmistry and Molecular Biology. (in press).
[Publications] Adachi,J.,Hasegawa,M.: "The Origin and Past of Modern Humans as Viewod from DNA (S.Brenner and K.Hanihara,eds.)" World Scientific Publ., 23 (1995)
[Publications] 長谷川政美、岸野洋久: "分子系統学" 岩波書店, (1996)
[Publications] 植田信太郎: "分子進化解析の技法とその応用" 共立出版(印刷中), (1996)
[Publications] 宝来聰: "臨床DNA診断法(古庄敏行・井村裕夫、監修編集)" 金原出版, 8 (1995)
[Publications] Horai S.: "The Origin and past of modern humans as viewed from DNA (S.Brenner and K.Hanihara,eds.)" World Scientific, 14 (1995)
[Publications] Horai S.et al.: "Prehistoric dispersal of Mongoloids (T.Akazawa and E.Szathmary,eds.)" Oxford University Press, 14 (1996)
[Publications] 宝来聰: "モンゴロイドの道(科学朝日編)" 朝日新聞社, 12 (1995)
[Publications] 宝来聰: "モンゴロイドの地球第3巻日本人のなりたち(百々幸雄編)" 東京大学出版会, 22 (1995)
[Publications] 宝来聰: "ゆらぎの科学5(武者利光編)" 森北出版, 31 (1995)
[Publications] 宝来聰: "新しい研究法は考古学になにをもたらしたか(田中啄・佐原真編)" クバプロ出版, 6 (1995)
[Publications] 宝来聰: "考古試料分析法(田口勇・斎藤努編)" ニューサイエンス社, 2 (1995)
[Publications] 堀寛(分担): "RNAの世界:遺伝暗号の謎に挑む" クバプロ, 214 (1995)

1995 Fiscal Year Annual Research Report

分子進化学の新展開

Principal Investigator

長谷川 政美 統計数理研究所, 予測制御系, 教授 (60011657)

Research Products

[Publications] Hashimoto,T.et al.: "Phylogenetic place of a mitochondrion-lacking protozoan,Giardia lamblia,inferred from amino acid sequences of elongation factd 2." Mol.Biol.Evol.12. 782-793 (1995)

[Publications] Hashimoto,T.et al.: "Phylogenetic place of kinetoplastid protozoaninferred from a protein phylogeny of elongation factor 1α." Mol.Biochem.Parasitol.70. 181-185 (1995)

[Publications] Adachi,J.,Hasegawa,M.: "Phylogeny of whales : dependence of the inference on species sampling." Mol.Biol.Evol.12. 177-179 (1995)

[Publications] Adachi,J.,Hasegawa,M.: "Improved dating of the human-chimpanzee separation in the mitochondrial DNA tree : heterogeneity among amino acid sites." J.Mol.Evol.40. 622-628 (1995)

[Publications] Adachi,J.,Hasegawa,M.: "Tempo and mode of synonymous substitutions in mitochondrial DNA of primates." Mol.Biol.Evol.13. 200-208 (1996)

[Publications] Nakamura,Y.et al.: "Phylogenetic place of kinetoplastid protozoa inferred from protein phylogenies of elongation factors 1α and 2." J.Biochem.,. 119. 70-79 (1996)

[Publications] Hashimoto,T.,Hasegawa,M.: "Origin and early evolution of eukaryotes inferred from the amino acid sequences of translation elongation factors 1α/Tu and 2/G" Advances in Biophysics. 32. 73-120 (1996)

[Publications] Adachi,J.,Hasegawa,M.: "Model of amino acid substitution in proteins encoded by mitochondrial DNA." J.Mol.Evol.(in press). (1996)

[Publications] Adachi,J.,Hasegawa,M.: "Instability of quartet analyses of molecular sequence data by the maximum likelihood method : The Cetaceal Artiodactyla relationships." Mol.Phyl.Evol.(in press). (1996)

[Publications] Hasegawa,M.,Adachi,J.: "Phylogenetic position of cetaceans relative to artiodactyls : Reanalysis of mitochondrial and nuclear sequences." Mol.Biol.Evol.(in press). (1996)

[Publications] Kuma,K.et al.: "Functional constraints against variations on molecules from tissue level : slowly evoluting brain specific genes demonstrated by protein kinase and immunoglobulin supergene familes." Mol.Biol.Evol.12. 123-130 (1995)

[Publications] Zhang,R,et al.: "Structures of cDNAs encoding the muscle-type and non-muscle-type Isozymes of lamprey fructose bisphosphate aldolases and the evolution of aldolase genes." J.Biochem.117. 545-553 (1995)

[Publications] Kuma,K.et al.: "Phylogenetic position of Dictyostelium inferred from multiple protein data sets." J.Mol.Evol.41. 238-246 (1995)

[Publications] Yokoyama,N.et al.: "A giant nucleopore protein which binds Ran/TC4" Nature. 376. 184-188 (1995)

[Publications] Iwabe,N.,et al.: "Molecular clock for dating of divergence between animal phyla." Jpn.J.Genet.ハ70. 687-692 (1995)

[Publications] Toshima,J.et al.: "Identification and characterization of a novel protein kinase,TESK1,specifically expressed in testicular germ cells." J.Biol.Chem.270. 31331-31337 (1995)

[Publications] Iwabe,N.et al.: "Evolution of gene families and relationship with organisural evolution : Rapid divergence of tissue-specific genes in the early evolution of chordates." Mol.Biol.Evol.(in press). (1996)

[Publications] Geng,L.et al.: "Determination of HLA class II alleles by genotyping in a Manchu population in the northern part of China and its relationship with Han and Japanese populations." Tissue Antigens. 46. 111-116 (1995)

[Publications] Shiina,T.et al.: "Isolation and characterization of cDNA clones for Japanese quail (Coturnic japonica) major histocompatibility complex (Mhc Coja) class I molecules." Immunogenetics. 42. 213-216 (1995)

[Publications] Ohba,K.et al.: "Relationships between serotypes and genotypes of hepatitis B virus : genetic classification of HBV by use of surface genes." Virus Research. 39. 25-34 (1995)

[Publications] Ohba,K.et al.: "Classification of hepatitis C virus into major types and subtypes based on molecular evolutionary analysis." Virus Research. 36. 201-214 (1995)

[Publications] Ikeo,K.et al.: "Different Evolutionary Histories of Kringle and Protease Domains in Serine Proteases-A Typical Example of Domain Evolution." Journal of Mol.Evol.40. 331-336 (1995)

[Publications] Ohba,K.et al.: "Evolutionary relationship of hepatitis C,pesti-,flavi-,plantviruses,and newly discovered GB hepatitis agents" FEBS Letters. 378. 232-234 (1996)

[Publications] Endo,T.et al.: "Large-Scale Search for Genes on Which Positive Selection May Operate." Molecular Biology and Evolution. (in press). (1996)

[Publications] Fumihito,A.et al.: "Monophyletic Origin and Unique Dispersal Patterns of Domestic Fowls." Proc.Natl.Acad.Sci.U.S.A.(in press). (1996)

[Publications] Yamamoto,H.et al.: "Regulatory regions of vertebrate tyrosinase genes : Divergence functional conservation." Proc.Natl.Acad.Sci.U.S.A.(in press). (1996)

[Publications] Oota,H.et al.: "A Genetic Study of 2,000-Year-Old Human Remarns Form Japan Using Mitochondrial DNA Sequeuces" American Journal of Physical Authropology. 98. 133-145 (1995)

[Publications] Watanabe,Y.et al.: "Characterization of Human-specific DNA Sequences obtained by Genome Subtraction" Human Evolution. 10. 63-68 (1995)

[Publications] Watanabe,Y.et al.: "Short Tandem Repeat Polymouphisns in Japanese macaques : tler short repeat lengths and low informativeness" Mammalian Genome. (in press). (1996)

[Publications] Kurosaki,K.et al.: "Sequence Variation Found in the Flaubiy Region of a Triheric Short taudem Repeat at the PLA2 locus" Japanese Journal of Legal Medrine. (in press). (1996)

[Publications] Horai S.et al.: "Recent African origin of modem humans revealed by complete sequences of hominoid mitochondrial DNAs." Proc.Natl.Acad.Sci.USA.92. 532-536 (1995)

[Publications] Umetsu K.et al.: "Orsomucoid phenotyping with monoclonal antibodies : Polymorphic occurrence of OPM1^*Q0 in aboriginal Taiwanese populations." Hum.Hered.45(4). 181-185 (1995)

[Publications] Hammer M.and Horai S.: "Y chromosomal DNA variation and the peopling of Japan." Am.J.Hum.Genet.56. 951-962 (1995)

[Publications] Jin F.et al.: "Genetic polymorphism of ADA in Taiwan aboriginal populations : New ADA variants detected by isoelectric focusing method." Antropol.Sci.103(3). 227-234 (1995)

[Publications] Hayashi S.et al.: "Molecular phylogeny of gibbons inferred from mitochondrial DNA sequences : Preliminary report." J.Mol.Evol.41(3). 359-365 (1995)

[Publications] Horai S.: "Evolution and origins of man : clues from complete sequences of hominoid mitochondrial DNA." Southeast Asian J.Trop.Med.Publ.Health 26 (Suppl.1). 146-154 (1995)

[Publications] Matsuo,M.et al.: "Mollusk gene encoding lysine tRNA (UUU) contain introns." Gene. 165. 249-253 (1995)

[Publications] Kido,Y.et al.: "Evolution of the Active Squence of the Hpa I Short interspersed Elements." J.Mol.Evol.41. 986-995 (1995)

[Publications] Murata,S.et al.: "Details of Retropositional Genome Dynamics That Provide a Rationale for a Generic." Genetics. 142(in press). (1996)

[Publications] Takasaki,N.et al.: "Characterization of Species-Specifically Amplified SINEs in Three Salmonid Species-Chum Salmon,Pink Salmon,and Kokanee." J.Mol.Evol.(in press). (1996)

[Publications] Koga,A.,Inagaki,H.,Bessho,Y.,Hori,H.: "Insertion of a novel transposable element in the tyrosinase gene is responsible for an albino mutation in the medaka fish,Oryzias latipes." Molecular and General Genetics. 249. 400-405 (1995)

[Publications] Fukuda,Y.,Hori,H.et al.: "Significance of the HLA-DQB matching in one-haplotype identical kidney transplant pairs and the matching analysis by the PCR-heteroduplex-polymorphism method" Tissue antigens. 45. 49-56 (1995)

[Publications] Inagaki,Y.,Hori,H.et al.: "Translation of synonymous codons in family boxes by Mycoplasma capricolum tRNAs with unmodified Uridine or adenine at the first anticodon position" Journal of Molecular Biology. 251. 486-492 (1995)

[Publications] Hori,H.,Watanabe,K.I.: "Medakafish homepage on the internet" The Fish Biology Journal MEDAKA. 7. 71-71 (1995)

[Publications] 堀 寛,稲垣秀人: "ネズミの腹はなぜ赤い:体色の分子進化" 細胞工学. 14. 999-1006 (1995)

[Publications] H.Charles,H.Ishikawa,P.Nardon: "Presence of a protein specific of endosymbiosis (symbionin) in the weevil Sitophilus" C.R.Acad.Sci.Paris. 318. 35-41 (1995)

[Publications] T.Sasaki,H.Ishikawa,: "Production of essential amino acids from glutamate by mycetocyte symbionts of the pea aphid,Acyrthosiphon pisum." J.Insect Physiol.41. 41-46 (1995)

[Publications] S.Okazaki,H.Ishikawa,H.Fujiwara: "Structural analysis of TRAS 1,a novel family of telomeric repeat associated retrotransposons in the silkworm,B.mori." Molecular and Cellular Biology. 15. 4545-4552 (1995)

[Publications] Iimura,Y,T.Sasaki,T.Fukatsu,H.Ishikawa: "Diminution of intracellular aymbiont of aphid maintained on artificial diet : A morphological study." Zoological Science. 12. 795-799 (1995)

[Publications] T.Sasaki,M.Kawamura,H.Ishikawa: "Nitrogen recycling in the brown planthopper,Nilaparvata lugens : Involvement of yeast-like endosymbionts in uric acid metabolism." J.Insect Physiol.(in press).

[Publications] T.Fukatsu,H.Ishikawa: "Phylogetic position of yeast-like symbiont of Hamiltonaphis styraci (Homoptera,Aphididae) based on 18S rDNA sequence." Insect Biochenmistry and Molecular Biology. (in press).

[Publications] Adachi,J.,Hasegawa,M.: "The Origin and Past of Modern Humans as Viewod from DNA (S.Brenner and K.Hanihara,eds.)" World Scientific Publ., 23 (1995)

[Publications] 長谷川政美、岸野洋久: "分子系統学" 岩波書店, (1996)

[Publications] 植田 信太郎: "分子進化 解析の技法とその応用" 共立出版(印刷中), (1996)

[Publications] 宝来 聰: "臨床DNA診断法(古庄敏行・井村裕夫、監修編集)" 金原出版, 8 (1995)

[Publications] Horai S.: "The Origin and past of modern humans as viewed from DNA (S.Brenner and K.Hanihara,eds.)" World Scientific, 14 (1995)

[Publications] Horai S.et al.: "Prehistoric dispersal of Mongoloids (T.Akazawa and E.Szathmary,eds.)" Oxford University Press, 14 (1996)

[Publications] 宝来 聰: "モンゴロイドの道(科学朝日編)" 朝日新聞社, 12 (1995)

[Publications] 宝来 聰: "モンゴロイドの地球 第3巻 日本人のなりたち(百々幸雄編)" 東京大学出版会, 22 (1995)

[Publications] 宝来 聰: "ゆらぎの科学5(武者利光編)" 森北出版, 31 (1995)

[Publications] 宝来 聰: "新しい研究法は考古学になにをもたらしたか(田中啄・佐原真編)" クバプロ出版, 6 (1995)

[Publications] 宝来 聰: "考古試料分析法(田口勇・斎藤努編)" ニューサイエンス社, 2 (1995)

[Publications] 堀 寛(分担): "RNAの世界:遺伝暗号の謎に挑む" クバプロ, 214 (1995)

長谷川政美統計数理研究所, 予測制御系, 教授 (60011657)

[Publications] 堀寛,稲垣秀人: "ネズミの腹はなぜ赤い:体色の分子進化" 細胞工学. 14. 999-1006 (1995)

[Publications] 植田信太郎: "分子進化解析の技法とその応用" 共立出版(印刷中), (1996)

[Publications] 宝来聰: "臨床DNA診断法(古庄敏行・井村裕夫、監修編集)" 金原出版, 8 (1995)

[Publications] 宝来聰: "モンゴロイドの道(科学朝日編)" 朝日新聞社, 12 (1995)

[Publications] 宝来聰: "モンゴロイドの地球第3巻日本人のなりたち(百々幸雄編)" 東京大学出版会, 22 (1995)

[Publications] 宝来聰: "ゆらぎの科学5(武者利光編)" 森北出版, 31 (1995)

[Publications] 宝来聰: "新しい研究法は考古学になにをもたらしたか(田中啄・佐原真編)" クバプロ出版, 6 (1995)

[Publications] 宝来聰: "考古試料分析法(田口勇・斎藤努編)" ニューサイエンス社, 2 (1995)

[Publications] 堀寛(分担): "RNAの世界:遺伝暗号の謎に挑む" クバプロ, 214 (1995)