• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1995 Fiscal Year Final Research Report Summary

MECHANISM OF HOST-DEPENDENT SELECTION OF INFLUENZA VIRUSES AND APPLICATION FOR THE DEVELOPMENT OF THE UNIVERSAL INFLUENZA VACCINE

Research Project

Project/Area Number 06454211
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Virology
Research InstitutionUNIVERSITY OF SHIZUOKA SCHOOL OF PHARMACEUTICAL SCIENCE

Principal Investigator

SUZUKI Yasuo  UNIVERSITY OF SHIZUOKA,SCHOOL OF PHARMACEUTICAL SCIENCE,PROFESSOR, 薬学部, 教授 (00046278)

Project Period (FY) 1994 – 1995
KeywordsINFLUENZA VIRUS / SIALIC ACID / EVOLUTION / RECEPTOR / SUGAR CHAIN / SIALIDASE / シアリターゼ
Research Abstract

1) Influenza viruses isolated from equine which contains Neu5Gc species of the sialic acid on the epitherial cells in the trachea preferentially bind to the Neu5Gc-containing glycoproteins and glycolipids, whereas, the viruses isolated from human which contains only Neu5Ac species binds to Neu5Ac-glycolipids. These results indicate that influenza virus isolates recognize the same sialic acid species in the receptor glycoproteins and glycolipids, such as Neu5Ac (N-acetyl-neuraminic acid) and Neu5Gc (N-glycolylneuraminic acid) , and also influenza viruses may be selected by the receptor sialic acid species on the host cell membranes.
2) Influenza viruses which isolated from MDCK cells recognize Neu5Ac2-6Gal-sequence, however, some influenza viruses which isolated from embryonic eggs (including CAM culture) preferentially bind to Neu5Ac2-3Gal sequence, indicating that the viral selection may be occurred depending on the host cell embrane receptor terminal sialic acid linkages, such as Neu5Ac2-3, and Neu5Ac2-6.
3) We found the common structure of the influenza virus receptor sialosugar chains, which is not affected by the antigenic variation and host cell selection.

  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Xu,G.,Suzuki,Y.,et al: "Sialidase of swine influenza viruses-Drift of the recognition specificity to sialyl linkages during the year of isolation" Glycoconugate J.12. 156-161 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki,Y.,Jyono,M.,et: "Labeling of influenza virus with alkylamice-modified horse radish peroxidase" Anal Biochem.228. 42-47 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kajihara,J.,Suzuki,Y. et al.: "Sulfatids,a specific sugar ligand for L-selectin,blocks CC14 induced liver inflammation" Biosci. Biotech. Biochem.59. 155-157 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Irie,F.,Suzuki,Y.,Hirabayashi,Y.: "Characterization of four monosialo and a novel disialo Asn-N-glycosides from the urine of a patient with aspartylglycosaminurea" Glycoconjugate J.12. 290-297 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mulligan,M. S.,Suzuki,Y. et al.: "Anti-inflammatory effects of sulfatides in selectin-dependent acute lung injury" International Immunol.7. 1107-1113 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyamoto,D.,Suzuki,Y. et al.: "Glycolipid acceptor specificity of a human Gabeta(1-3/1-4) GlcNAcalpha2,3-sialyltransferase" Biochem. Biophys. Res. Commun.217. 852-858 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ahmed,K.,Suzuki,Y. etal.: "Effects of anti-receptor antibodies on the adherence of Moraxella catarralis" Bacterial Adhearance. 9. 15-16 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki,Y.: "Sulafted glycolipids-Potential receptors for viruses and as their role in inflammation in kedney ans lung" Neurochemistry. 65. S67C (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki,Y.: "Variation of influenza viruses,their recognition of the receptor sugar chains and the development of anti-influenza drugs" Abstract for the 1st Internatinal symposium on cell adhesion and anti-adhesion. 1. 11-24 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 鈴木康夫: "インフルエンザウイルス腫抗原の分子進化とその受容体シアロ糖鎖識別機構" 学術月報. 48. 589-595 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 鈴木康夫(編・著): "ガングリオシド研究法I" 学会出版センター, 259 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 鈴木康夫(編・著): "ガングリオシド研究法II" 学会出版センター, 273 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Xu, G., Suzuki, Y., et.al.: "Sialidase of swine influenza A viruses -Drift of the recognition specificity to sialyl linkages during the year of isolation" Glycoconjugate J.12. 156-161 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, T., Jyono, M., Suzuki, Y., et.al.: "Labeling of influenza virus with alkylamine-modified horse radish peroxidase" Anal.Biochem.228. 42-47 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kajihara, J., Suzuki, Y., et.a.: "Sulfatide, a specific sugar ligand for L-selectin, blocks CC14 induced liver inflammation in rats." Biosci., Biotech., Biochem.59. 155-157 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Irie, F., Suzuki, Y., Hirabayashi, Y., et.al.: "Characterization of four monosialo and a novel disialo Asn-N-glycosides from the urine of a patient with aspartylglycosaminursa." Glycoconjugate J.12. 290-297 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mulligan, M.S., Suzuki, Y., et.al.: "Anti-inflammatory effects of sulfatides in selectin-dependent acute lung injury." International Immunol.7. 1107-1113 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyamoto, D.Suzuki, Y., et.al.: "Glycolipid acceptor specificity of human Gal beta (1-3/1-4) GlcNAc alpha2,3-sialyltransferase." Biochem.Biophys.Res.Commun.217. 852-858 (1995)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1997-03-04  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi