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1995 Fiscal Year Final Research Report Summary

Effect of Lymphokine on Saltatory Nerve Conduction in Single Myelinated Nerve Fibers.

Research Project

Project/Area Number 06670651
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

KAJI Ryuji  Faculty of Medicine, Kyoto University Lecture, 医学研究科, 講師 (00214304)

Co-Investigator(Kenkyū-buntansha) KOHARA Nobuo  Faculty of Medicine, Kyoto University Assistant, 医学研究科, 助手 (20252439)
KIMURA Jun  Faculty of Medicine, Kyoto University Professor, 医学研究科, 教授 (10204976)
Project Period (FY) 1994 – 1995
Keywordslymphokine / anti-GM1 antibody / conduction block / multifocal motor neuropathy / Guillan-Barre syndrome / Na Channel / single fiber recording
Research Abstract

Antiganglioside antibodies are found in the axonal form of Guillain-Barre syndrome and multifocal motor neuropathy. Several studies indicated that they may produce conduction block through Na channel inactivation. To confirm this contention, we devised a method to analyze saltatory conduction in single myelinated fiber under the influence of the sera. Despite the premise, we found conduction block in only 2 out of 38 fibers examined with high-titer anti-GM1 rabbit serum. None showed conduction block by human sera. Only one out of 25 exhibited block after exposure to lymphokine produced by lymphocytes incubated with the anti sera. These finding do not support the view that these sera play an important role in the pathogenesis of these diseases.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Hirota N, Kaji R, Bostock H, Shindo K, et al: "The effect of anti-GM1 antibodies on saltatory conduction and fransmembrane curret in vivo." (in preparation).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaji R et al: "Anti-GM1 antibodies and impaired blood-nerve barrier may interfere with remylination in multifocal motor neuropathy." Muscle Nerve. 17. 108-110 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Watanabe T et al: "U1tra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy." J. Neurol. Sci.122. 140-143 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mezaki T et al: "Comparison of therapeutic efficacies of types A and F botulinum toxins for blepharospasm." Neurology. 45. 506-508 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaji R et al: "Physiological study of cervical dystonia: task specific abnormality in contingent negative variation." Brain. 118. 511-522 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaji R et al: "Tonic vibration reflex and muscle afferent block in writer′s cramp." Ann Neurol. 38. 155-162 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hirota N,Kaji R,Bostock H,Shindo K,et al.: "The effect of anti-GM1 antibodies on saltatory conduction and fransmembrane curret in vivo." (in preparation).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaji R et al.: "Anti-GM1 antibodies and impaired blood-nerve barrier may interfere with remylination in multifocal motor neuropathy." Muscle Nerve. 17. 108-110 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe T et al.: "Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy." J.Neurol.Sci. 122. 140-143 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mezaki T et al.: "Comparison of therapeutic efficacies of types A and F botulinum toxins for blepharospasm." Neurology. 45, March. 506-508 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaji R et al.: "Physiological study of cervical dystonia : task specific abnormality in contingent negative variation." Brain. 118. 511-522 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaji R et al.: "Tonic vibration reflex and muscle afferetn block in writer's cramp" Ann Neurol. 38. 155-162 (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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