1995 Fiscal Year Final Research Report Summary
Difference of sensitivity to the chemoprevention (cisplatin vs.cv-3611 or SOD) between young and gerontic mice
Project/Area Number |
06671269
|
Research Category |
Grant-in-Aid for General Scientific Research (C)
|
Allocation Type | Single-year Grants |
Research Field |
Digestive surgery
|
Research Institution | Osaka University |
Principal Investigator |
FUJIMOTO Jiro Osaka Univ., Fac.Med., Surg.II,Instructor, 医学部, 助手 (60028610)
|
Project Period (FY) |
1994 – 1995
|
Keywords | chemoprevention / aging / spontaneous carcinogenesis / CDDP-induced carcinogenesis / SOD / CV-3611 |
Research Abstract |
Difference of suppressive effects of a scavenger of the active oxygen species, 2-0-octadecyl ascorbic acid (CV-3611), on development of spontaneous (sp.) and cisplatin (CDDP)-induced malignant tumors between young and gerontic C3H/He mice. The incidence of tumor was significantly (sg.) higher and mean survival time sg.lower in female mice intraperitoneally injected with 10 times 2 mg/kg CDDP than in the control group, while incidence of tumor was lower and survival time longer in female mice subcutaneously (sc) injected with 10 times 5 mg/kg CV-3611 than in the control group. Mice injected with both CV-3611 and CDDP showed lower tumor incidence and sg.longer survival time than those injected with CDDP alone. Male mice showed the same tendency as female in function of CDDP and CV-3611. Tumor-inducing ability of CDDP in gerontic mice was the same as in young mice, but suppressive effects of CV-3611 in gerontic mice slight. Effects of SOD or CV-3611 on sp.and CDDP-induced carcinogenesis in young C3H/He mice. Cv-3611 (total dose, 50 mg/kg) sg.suppressed and delayd sp.and CDDP-induced malignant tumors in mice. However, in the case of the mice which survived to times 2 mg/kg SOD sc with or without CDDP,suppression and delay of sp.and CDDP-induced carcinogenesis was slight in the male mice, but carcinogenesis was rather enhanced in female mice.
|
Research Products
(12 results)