1996 Fiscal Year Final Research Report Summary
Pathophysiological・Biochemical Cooperative Studies by Linkage Analysis on Hypertension Genes in SHR
| Project/Area Number |
07308076
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 総合 |
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| Research Field |
Laboratory animal science
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
YAMORI Yukio Professor, Graduate School of Human and Environmental Studies, Kyoto University, 大学院・人間・環境学研究科, 教授 (80025600)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAO Kazuwa Protessor, Kyoto University, Faculty of Medicine, 医学部, 教授 (00172263)
NINOMIYA Ishio Professor, Institute of Health Sciences, Hiroshima University school of Medicine, 医学部, 教授 (80033976)
KUROKAWA Kiyoshi Professor, School of Medicine, Tokai University, 医学部, 教授 (30167390)
SAWAMURA Makoto Assistant, Graduate School of Human and Environmental Studies, Kyoto University, 大学院・人間・環境学研究科, 助手 (00187303)
NARA Yasuo Associate Professor, Graduate School of Human and Environmental Studies, Kyoto U, 大学院・人間・環境学研究科, 助教授 (80116417)
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| Project Period (FY) |
1995 – 1996
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| Keywords | Hypertension / Stroke / Gene / Linkage analysis / Renal function / Cardiac hypertrophy / Endocrine system / Intracellular message transduction |
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| Research Abstract |
Linkage analyzes of genes related to hypertension and stroke were cooperatively carried out in the F_2 generation obtained by cross breeding of spontaneously hypertensive rats (SHR) or stroke-prone SHR (SHRSP) with their control normotensive Wistar-Kyoto (WKY) rats which had been established all as the reference strains such as SHR/Izm, SHRSP/Izm and WKY/Izm. These sets of F_2 rats were carefully observed for the development of hypertension, stroke and other phenotypes related to these pathophysiological conditions, and the following results of the linkage analyzes were obtained.
1) Strong linkage with systolic blood pressure (SBP) was detected at 3 loci on Chromosome (Chr.) 1 (DIMIT2), Chr.3 (D3Mgh16) and Chr.4 (TRY1), and less strong linkage was observed at 2 loci on Chr.9 and 10. Blood pressure distribution in the F_2 rats was explained mostly by the genetic influence of these 5 loci.
2) On Chr.1 the major gene related to SBP located within 35cM from gene loci of LSN and MYL2.
3) Among the F_2 obtained from crosses between SHRSP/Izm and WKY/Izm. 9 rats developed stroke within 1 year after birth. One locus on Chr.4 was detected to associate with the development of stroke but not with blood pressure, indicating firstly the possible involvement of this region in the pathogenesis of stroke unrelated to hypertension itself.
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Research Products
(16 results)
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[Publications] Matsumoto, C., Nara, Y., Ikeda, K., Tamada, T., Mashimo, T., Nabika, T., Sawamura, M., Yamori, Y.: "Cosegregation of the new region on chromosome 3 with salt-induced hypertension in female F2 progeny from stroke-prone spontaneously hypertensive and Wistar-Kyoto rats." Clin. Exp. Pharmacol. Physiol.23. 1028-1034 (1996)
Description
「研究成果報告書概要(和文)」より
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[Publications] Nara, Y., Ikeda, K., Matsumoto, C., Nabika, T., Sawamura, M., Yamori, Y.: "In search of genes causing spontaneous hypertension." Clin. Exp. Pharmacol. Physiol.22 (Suppl. 2). S382-S385 (1995)
Description
「研究成果報告書概要(和文)」より
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[Publications] Matsumoto, C., Nara, Y., Ikeda, K., Nabika, T., Sawamura, M., Yamori, Y.: "A new locus on chromosome 3 strongly linked with salt-sensitive high blood pressure in female F2 from SHRSP and WKY rats." Clin. Exp. Pharmacol. Physiol.22 (Suppl. 1). S2-S3 (1995)
Description
「研究成果報告書概要(和文)」より
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[Publications] Takava, K., Ogawa, Y., Hiraoka, J., Hosoda, K., Yamori, Y., Nakao, K., Koletskv, RJ.: "Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat." Nature Genetics. 14. 130-131 (1996)
Description
「研究成果報告書概要(和文)」より
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[Publications] Matsumoto, C., Nara, Y., Ikeda, K., Tamada, T., Mashimo, T., Nabika, T., Sawamura, M., Yamori, Y.: "Cosegregation of the new region on chromosome 3 with salt-induced hypertension in female F2 progeny from stroke-prone spontaneously hypertensive and Wistar-Kyoto rats." Clin.Exp.Pharamcol.Physiol.23. 1028-1034 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Nara, Y., Ikeda, K., Matsumoto, C., Nabika, T., Sawamura, M., Yamori, Y.: "In search of genes causing spontaneous hypertension." Clin.Exp.Pharmacol.Physiol.22(Suppl.2). S382-S385 (1995)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Matsumoto, C., Nara, Y., Ikeda, K., Nabika, T., Sawamura, M., Yamori, Y.: "A new locus on chromosome 3 strongly linked with salt-sensitive high blood pressure in female F2 from SHRSP and WKY rats." Clin.Exp.Pharmacol.Physiol.22(Suppl.1). S2-S3 (1995)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Nara, Y., Ikeda, K., Matsumoto, C., Mashimo, T., Tamada, T., Sawamura, M., Yamori, Y., Nabika, T.: "Salt-sensitive hypertension genes in female stroke-prone SHR." Ketsuatsu. 3(no.2). 62-67 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Takaya, K., Ogawa, Y., Hiraoka, J., Hosoda, K., Yamori, Y., Nakao, K., Koletsky, RJ.: "Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat." Nature Genetics.14. 130-131 (1996)
Description
「研究成果報告書概要(欧文)」より
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