| Research Abstract |
Result of DNA ploidy analysis in the study revealed that non-diploid (including aneuploid and euploid-polyploid) osteosarcoma was more sensitive to chemotherapy than diploid one. Adriamycin binding study showed that adriamycin binding ability was closely correlated with histological response to chemotherapy in human osteosarcomas. Multigrug resistant mouse osteosarcoma cells which was established in the study was resistant not only adriamycine also vincristin, bleomycine, mitomycine etc. This cell line was found to be useful for experimental study on overcoming of resistance. In various overcoming methods for resistance, verapamil, cyclosporin A,MS 209, Tween 20 or 80, electoron magnetic field, radiation were useful in mouse osteosarcoma. However, clinically electron magnetic field and MS 209 may available, because two of these were not toxic for human body.
|
