1997 Fiscal Year Final Research Report Summary
ANTICOAGULANT ACTIVITY OF SULFATIDE AND ITS EFFECTS ON ARTERIOSCLEROSIS
| Project/Area Number |
07670141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | SHINSHU UNIVERSITY |
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Principal Investigator |
HARA Atsushi SHINSHU UNIVERSITY,LECTURER, 医学部附属加齢適応研究センター, 講師 (70126697)
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| Co-Investigator(Kenkyū-buntansha) |
UEMURA Kei-ichi SHINSHU UNIVERSITY,ASSOCIATE PROFESSOR, 医学部附属加齢適応研究センター, 助教授 (80012756)
TAKETOMI Tamotsu SHINSHU UNIVERSITY,PROFESSOR, 医学部附属加齢適応研究センター, 教授 (30020704)
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| Project Period (FY) |
1995 – 1997
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| Keywords | SULFATIDE / ANTICOAGULANT / FIBRINOGEN / PROTHROMBIN TIME / THROMBIN / BLEEDING TIME / PLATELET |
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| Research Abstract |
SULFATIDES (GALACTOSYLCERAMIDE I^3-SULFATE), WHICH ARE FOUND IN SERUM LIPOPROTEINS OF VARIOUS MAMMALS,EFFECTIVELY INCREASED PROTHROMBIN TIME (ANTICOAGULANT EFFECT) AND ALSO EFFECTIVELY PROLONGED BLEEDING TIME (ANTI-PLATELET EFFECT). WHEN EQUAL VOLUMES OF A HOMOGENEOUS MICELLAR SOLUTION OF SULFATIDE AND FIBRINOGEN IN PHOSPHATE BUFFERED SALINE WERE MIXED,AN INSOLUBLE COMPLEX PRECIPITATED.ANALYSIS OF THE PRECIPITATED COMPLEX SHOWED THAT THE MOLAR RATIO OF SULFATIDE TO FIBRINOGEN WAS ABOUT 400 : 1. THESE RESULTS INDICATE THAT THE SULFATIDE MICELLEBINDS TIGHTLY TO FIBRINOGEN AND THEREBY INTERFERES WITH BOTH FIBRIN GEL FORMATION (ANTICOAGULANT ACTIVITY) AND PLATELET FUNCTION.
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