1997 Fiscal Year Final Research Report Summary
The role of cytokine on the defense against cutaneous mycosis
Project/Area Number |
07670976
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Dermatology
|
Research Institution | Fukuoka University |
Principal Investigator |
KOGA Tetsuya Fukuoka University, School of Medicine, Associate Professor, 医学部, 助教授 (20195697)
|
Project Period (FY) |
1995 – 1997
|
Keywords | dermatophytosis / sporotrichosis / cytokine / IFN-gamma / IL-8 / GM-CSF / keratinocyte / T cell |
Research Abstract |
1. T cell-derived cytokines (IFN-gamma, GM-CSF) are involved in he elicitation of the delayd-type hypersensitivity response. We showed that the production of IFN-gamma, GM-CSF in response to stimulation with trichophytin was detressed in the peripheral blood mononuclear cells obtained from patients who had chronic dermatophyte infection, when compared with that in the PBMC obtained from non-chromatophyte infected patients. It is possible that decreased release of cytokines at the site of infection might explain the inability of chronically infected patients to eradicate dermatophytes from the skin. 2. Subcorneal pustules during dermatophytic infections are not a characteristic of DTH.The stimulation of trichophytin significantly enhanced the release of IL-8 from keratinocytes, perhaps accounting for the accumulation of neutrophils beneath the stratum cornum. It therefore appears that some clinical manifestations of dermatophytosis and host defenses can be attributed to DTH and keratinocyte-stimulation by dermatophyte antigen. 3. IFN-gamma was present in the culture supernatant, after a 72-hour incubation with sporotrichin of the peripheral blood mononuclear cells obtained from the patient with sporotrichosis. These findings suggest that IFN-gamma produced by sporotrichin-specific T cells may thus play a role in the development of cutaneous lesions in sporotrichosis.
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Research Products
(12 results)