1996 Fiscal Year Final Research Report Summary
Conformational Analysis and Molecular Design of Polypeptides for Creating Advanced Biomaterials
| Project/Area Number |
07680959
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
OKA Masahito Osaka Prefecture University, Research Institute for Advanced Science and Technology Associate Professor, 先端科学研究所, 助教授 (70203966)
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| Project Period (FY) |
1995 – 1996
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| Keywords | proteins / polypeptides / conformation / molecular mechanics / peptide synthesis / circular dicroism / helix / biomaterials |
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| Research Abstract |
Theoretical conformational analysis was tried for the periodic polypeptides having repetitive amino-acid sequences which are found in many native periodic proteins such as collagen, elastin, bactenecin, gamma-Zein, et al., and it was shown that they form new interesting helical conformations which are supposed to relate to the molecular functions of such periodic proteins. Experimental analysis was also tried for the synthetic periodic polypeptides, and experimental results supporting the theoretical results were obtained. Moreover, theoretical conformational analysis was tried for the super secondary structures constructed by the secondary structures such as alpha-helices, beta-strands, and polyproline-II structures. It was shown that there are many super secondary structures having interesting structural character from the viewpoints designing new useful.
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