1996 Fiscal Year Final Research Report Summary
The expression of Immediate Eearly Gene (IEG) during development.
Project/Area Number |
07808092
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | TOKYO INSTITUTE OF PSYCHIATRY |
Principal Investigator |
MURASHIMA Yoshiya TOKYO INST.PSYCHIAT DEPT.Neurophy siology, Dept.Director, 神経生理研究部門, 副参事研究員 (50182118)
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Project Period (FY) |
1995 – 1996
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Keywords | Epileptie Mutant / Abnormal Plasticity / Immediate Eearly Gene / GABA / GAD |
Research Abstract |
To examine the hypothesized role of the IEG response in synaptic plasticity and further the formation of abnormal plasticity in epileptogenesis, we studied the expression of IEGs in El mice, a well known mutant model of epilepsy. In the present study, it was obserbed that zif was expressed maximally 30 min after seizure in both cerebrum and cerebellum under the same condition of the seizure threshold. There were no regional differences. Results as examined with seizure history indicate that in the limbic system the maximum expression site shifts from the pyriform cortex and entorhinal cortex to the dentate gyrus and further to ther hippocampal CA3 and CA1 by frequent seizures. On the other hand, results with development indicate that through the development as well as repetitive seizures, the c-fos expression site shifts gradually from the primary input system of the hippocampus ; i.e., the pyriform cortex, entorhinal cortex and dentate gyrus, to the hippocampal CA1. It is also indicated as for the parietal cortex that the expression site is initially localized and then becomes universal. It is further demonstrated that the expression site finally becomes universal and weak in all over the cortex.
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Research Products
(9 results)
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[Publications] "Regional, differences, of, immediate, early, gene, expressions, and, GABAergic, abnormalities, in, the, brain, of, EL,mice." Epilepsy, Res.26. 3-14 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] "GABAergic, abnormalities, and, IEG,expressions, might, be, involved, in, the, formation, of abnormal, plasticity, in, EL,mice." Epilepsia. 37 (3). 61-62 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] "Role, of, Immediate, Eary, Genes, expression, during, establishment, of epileptogenesis, in, the, brain, of, EL,mice." Psychiatr, Clin.Neurosci. 49. 201-206 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Role, of, free, radicals, through, the, hippocampus, specific, Cu, Zu-SOD,abnormalitiesin, the, formation, of, abnormal, plasticity, in, epileptic, mutant, EL,mice.In, Free, radicals, in, brain, physiology, and, disorders, (Eds., Mori, A., et, al) Elsevier, , North, holland, , London, , Paris, , New, York., 157-172 (1996)
Description
「研究成果報告書概要(欧文)」より