• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1996 Fiscal Year Final Research Report Summary

Regulation of Gene Expression

Research Project

Project/Area Number 08044247
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionChiba University, School of Medicine

Principal Investigator

TANIGUCHI Masaru  Chiba University, School of Medicine, Professor, 医学部, 教授 (80110310)

Co-Investigator(Kenkyū-buntansha) KUZUYAMA Tomohisa  University of Tokyo, Institute of Molecular and Cellular Biosciences, Assist. (30280952)
YOKOYAMA Kenji  Japan Advanced Institute of Science and Technology, Hokuriku, School of Material (80242121)
YASUDA Kunio  Nara Institute of Science and Technology, Graduate School of Biological Sciences (30025473)
KOSEKI Haruhiko  Chiba University, School of Medicine, Assist. (40225446)
WATANABE Takeshi  Kyusyu University, Medical Institute of Bioregulation, Prof. (40028684)
Project Period (FY) 1996
KeywordsT cell / Immunological tolerance / B cell / Transgenics / Polycomb genes / Crystallin gene / Biosensor / Transcriptional factor
Research Abstract

(1) Immunology
Upon the agreement with CNRS,France in 1989, a joint research program in the field of immunology was first undertaken in 1994. In this fiscal year 1996 the research was focused on the following 4 points : a) Molecular basis for T cell differentiation, T cell tolerance, and pathogenesis of autoimmune disease ; b) Regulation of signal transducing cascade and gene expression during B cell development ; c) Molecular basis underlying signal transduction via antigen receptor complexes ; and d) Development and pathogenesis of immune system. Several remarkable achievements were established by using mouse transgenic techniques and they greatly contributed the establishment of new region of transgenics.
(2) Embryology
a) Functions of mammalian Polycomb group gene products were investigated. Genetic analysis using mel-18 and bmi-1 deficient mice revealed that these gene products were synergically required for the establishment of anterior-posterior axis. b) Enhancer elements required for the tissue specific expression of BETAB1-crystallin were identified by using cell culture and transgenic system.
(3) Molecvlar Recognition
The chemical compound, Thiosrepton, activated transcriptional activity of Thiosrepton-binding protein. Derivatives of Thiosrepton also possessed the same biological activity which was strongly correlated with the length of Deala-side chain.
(4) Biosensor
The highly sensitive biosensor to detect the trace of an insecticide containing organic phosphorus was developed by using Acetylcholine esterace (AChE).

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Akasaka,T.: "A role for mel-18,a Polycomb group-releted vertebrate gene,during the anteroposteior specification of the axial skeleton." Development. 122. 1513-1522 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Duncan,M.K.: "Developmenta regulatio of the chicke βB1-crystalin promoter in transgenic mice" Mechanisms of Development. 57. 79-89 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Taniguchi,M.: "Essential requirement of an invariant Vα14 T cell antigen receptor expression in the development of natural killer T cells" Proc.Natl.Acad.Sci.USA. 93. 11025-11028 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akasaka, T.et al.: "A role for mel-18, a Polycomb group-related vertebrate gene, during the ateroposterior specification of the axial skeleton" Development. 122. 1513-1522 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Duncan, M.K.et al.: "Developmental regulation of the chicken BETAB1-crystalin promoter in transgenic mice" Mechanisms of Development. 57. 79-89 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Taniguchi, M.et al.: "Essential requirement of an invariant Valpha14 T cell antigen receptor expression in the development of natural killer T cells" Proc.Natl.Acad.Sci.USA. 93. 11025-11028 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1999-03-09  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi