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1997 Fiscal Year Final Research Report Summary

Risk Assessment of Asbestos Workers

Research Project

Project/Area Number 08045070
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionUniversity-to-University Cooperative Research
Research Field Public health/Health science
Research InstitutionTeikyo University

Principal Investigator

YANO Eiji  Teikyo University, School of Medicine, Professor, 医学部, 教授 (50114690)

Co-Investigator(Kenkyū-buntansha) KELSEY Karl T  Harvard School of Public Health, Associate Professor, 公衆衛生学部, 准教授
CHRISTIANI David C  Harvard School of Public Health, Professor, 公衆衛生学部, 教授
YAMANOUCHI Yasuko  Teikyo University, School of Medicine, Instructor, 医学部, 助手 (40246038)
Project Period (FY) 1996 – 1997
Keywordsasbestos / dust / reactive oxygen metabolites / respiratory function / selection bias / smoking / ethnicity / molecular epidemiology
Research Abstract

To provide basic information for an earlier diagnosis and effective prevention program for asbestos related diseases, using recent progressed research technologies of epidemiology, cyotogenetics, and molecular epidemiology, health risk assessment of asbestos workers wasmperformed with the special reference to type of exposed dust, sex, race, and smoking in addition to bias related to epidemiological studies. The major results obtained were as follows :
1. The mechanism of human PMN to generate ROM by crocidolite was shown to involve both to direct cell surface membrane interactions, together with an apparent phagocytic-dependent process.
2. Results of the first pulmonary function test were shown to associate with the mortality and participation in a subsequent reexamination, suggesting a selection effects in a longitudinal study of pulmonary function. 3. Pulmonary function of nonsmoking female asbestos workers without asbestosis were examined and found that asbestos-esposure per se predominantly contributes to restircted lung volume and reduced DLco. 4. Pulmonary dysfunction among workers exposed to silica, asbestos, or coalmine dust were compared and all the three dusts was found to cause functional abnormalities that precede radiographic changes of pneumoconiosis. 5. The ethnic distribution of the polymorphism of the NAD (P) H quinone oxidoreductase, was described and its implications for anti-tumour drug development and use were discussed. 6. A case-control study to investigate the association of the GSTT1 and GSTM1 polymorphisms with lung cancer in minority populations suggested that lung cancer risk is increased more than additively for individuals who have both GSTT1 and GSTM1 null polymorphisms. 7. The current strengths and limitations of environmental molecular epidemiology in controlling disease caused by air toxics are illustrated with examples.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] T Ishizaki,E Yano et al: "Cellular mechanisms of reactive oxygen metabolisms generation from human polymorphonuclear leukocytes induced by crocidolite asbestos." Environmental,Research. 75. 135-140 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 苅田香苗, 王 暁蓉, 他: "呼吸機能検査受診者の15年後の追跡調査-再受診者の特性について-" 日本公衆衛生雑誌. 43. 318 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] XR Wang, E Yano,et al: "Respiratory impairments due to dust exposure:a comparative study among workers exposed to silica,asbestos,and coalmine dust." American Journal of Industrial Medicine. 31. 495-502 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] XR Wang, E Yano,et al: "Pulmonary function of nonsmoking female asbestos workers without radiographic signs of asbestosis." Archives of Environmental Health. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] KT Kelsey,D Ross,et al: "Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy." British Journal of Cancer. 76. 852-854 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] KT Kelsey,MR.Spitz,et al: "Polymorphisms in the glutathione S-transferase class mu and theta genes interact and increase susceptibility to lung cancer in minority populations(Texas,United States)." Cancer Causes and Control. 8. 554-559 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] DC Christiani: "Utilization of biomarker data for clinical and environmental intervention." Environmental Health Perspectives. 104 Suppl 15(2). 921-924 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T Ishizaki, E Yano, PH.Evans: "Cellular mechanisms of reactive oxygen metabolites generation from human polymorphonuclear leukocytes induced by crocidolite asbestos" Environ Res. 75. 135-140 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Karita et al.: "Fifteen years' follow-up of examinee of pulmonary function test-selection effects on an estimation of long-term changes (in Japanese)" Jpn J Public Health. 43. 318 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] XR Wang, E Yano, K Nonaka, MZ Wang, ZM Wang: "Respiratory impairments due to dust exposure : a comparative study among workers exposed to silica, asbestos, and coalmine dust." Am J Indust Med. 31. 495-502 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] XR Wang, E Yano, K Nonaka, MZ Wang, ZM Wang.: "Pulmonary function of nonsmoking female asbestos workers without radiographic signs of asbestosis." Arch Environ Health. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] KT Kelsey, D Ross, RD Traver, DC Christiani, Z-F Zuo, MR Spitz, M Wang, X Xu, B-K Lee, BS Schwartz, JK Wiencke: "Ethic variation in the prevalence of a common NAD (P) H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy." Br J Cancer. 76. 852-854 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] KT.Kelsey, Mr.Spitz, Z-F Zuo, JK.Wiencke: "Polymorphisms in the glutathione S-transferase class mu and theta genes interact and increase susceptibility to lung cancer in minority populations (Texas, United States)." Cancer Causes and Control. 8. 554-559 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] DC Christiani: "Utilization of biomarker data for clinical and environmental intervention." Environ Health Perspect. 104 : (suppl5). 921-924 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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