1997 Fiscal Year Final Research Report Summary
Amotivational syndrome induced by organic solvent inhalation
| Project/Area Number |
08671098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
FUKUI Kenji Kyoto Prefectural University of Medicine, School of Medicine, Professor, 医学部, 教授 (50165263)
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| Project Period (FY) |
1996 – 1997
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| Keywords | Organic solvent / Amotivational syndrome / Hippocampus / Electron microscopy / Neurotoxicity / Behavioral pharmacology |
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| Research Abstract |
We examined changes of the dentate gyrus of the rat hippocampus following 1 or 3 month toluene exposure, using glial fibrillary acidic protein (GFAP) immunocytochemistry, and electron microscopy.
In 1 month toluene-treated rats, the number and intensity of of GFAP-immunoreactive (IR) processes were markedly increased, and thick GFAP-IR processes appeared, entering into the granular cell layr. However, no apparent degenerative features were observed. In 3 months toluene-treated rats, some of granular cells showed degenerative features such as swelling of perikarya, the decrease of cell organelles and infusion of adjacent cytoplasmic membrane.
These results suggest that the neurotoxic effects of toluene and the protective function of astrocytes are balanced at least for 1 month, but the balance is broken up and results in neurodamages for 3 months exposure.
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