1997 Fiscal Year Final Research Report Summary
An analysis of inhibitory mechanism of colonic carcinoma and hepatic metastasis by apple pectin
| Project/Area Number |
08671343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY |
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Principal Investigator |
TAZAWA Kenji TOYAMA MED & PHARMA UNIV.SCHOOL OF MEDICINE,PROFESSER, 医学部, 教授 (80018887)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Masatoshi TOYAMA MED & PHARMA UNIV.SCHOOL OF MEDICINE,ASSISTANT, 医学部, 教務職員 (30143861)
HONDA Takashi TOYAMA MED & PHARMA UNIV.SCHOOL OF MEDICINE,VICE PRESIDENT, 副学長 (40019914)
TAKEMORI Shigeru TOYAMA MED & PHARMA UNIV.SCHOOL OF MEDICINE,LECTURER, 附属病院, 講師 (30227061)
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| Project Period (FY) |
1996 – 1997
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| Keywords | Apple pectin / Dietary fiber / Hepatic metastasis / free radical / Carcinogeneses / pectin / Cancer prevention |
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| Research Abstract |
Highly reactive oxygen-derived free radicals may play a role in carcinogenesis and hepatic metastasis. Free radical scavenging activity of apple pectin (Oligosaccharides and Oligogalacturonic acids) and components of Oligosaccharides used for the attenuation of colon carcinogenesis and hepatic metastasis, were investigated in vivo and in vitro. The used exprimental system was a radical scavenging action against superoxide anion radical and hydroxyl radical by the electron spin resonance technique. Oligosaccharides of apple pectin showed radical scavenging activity in a concentration-dependent manner in vitro, while on the han there are not significant in vivo. Components of Oligogalacturonic acids showed radical scabenging activity only in lowest molecular weight. The results indicate that the components of apple pection treated for prevention of carcinogenesis and metastasis were good radical scabenger that could possibly prevent the immune suppression of hepato-portal system.
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Research Products
(12 results)
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[Publications] Ohnishi Y., Fujii H., Kimura F., Mishima T., Murata J., Tazawa K., Fujimaki M., Okada F., Hosokawa M., Saiki I.: "Inhibitory effect of atraditional Chinese medicine, Juzen-taiho-to, on progressive growth of weakly malignant clone cells derived from murine fibrosarcoma" Jpn.J.Cancer Res.87. 1039-1044 (1996)
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「研究成果報告書概要(欧文)」より
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[Publications] Tazawa K., Ohnishi Y., Ohkami H., Okamoto M., Yuguchi T., Yamashita I., Masuyama K., Yamamoto K., Takemori S., Arai H., Sakamoto T., Fujimaki M.: "Intestinal flora and cancer control : inhibitory effect of oral administration of Lactobacillus casei in a model of hepatic metastasis of rat" In : Ohigashi H., Osawa T.eds.International Conference on Food Factors : Chemistry and Cancer Prevention. Spring-Verlag, Tokyo. 367-370 (1997)
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「研究成果報告書概要(欧文)」より
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