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2000 Fiscal Year Final Research Report Summary

Super-Biosystem Constructed by Cognitive Multidimensional Glyco-Molecules

Research Project

Project/Area Number 09240102
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionTeikyo University of Science and Technology (1999-2000)
The University of Tokyo (1997-1998)

Principal Investigator

URYU Toshiyuki  Teikyo University of Science and Technology, Department of Environment Material and Material Engineering, Professor, 理工学部, 教授 (80011005)

Co-Investigator(Kenkyū-buntansha) FURUKAWA Kiyoshi  Tokyo Metropolitan Institute of Gerontology, Department of Biosignal Research, Head, 室長 (10190133)
KOBAYASHI Kazukiyo  Nagoya University, Department of Molecular Design and Engineering, Professor, 大学院・工学研究科, 教授 (10023483)
NISHIMURA Shin-ichiro  Hokkaido University, Division of Biological Sciences, Professor, 大学院・理学研究科, 教授 (00183898)
HATANAKA Kenichi  University of Tokyo, Institute of Industrial Science, Associate Professor, 生産技術研究所, 助教授 (70167584)
AKIYOSHI Kazunari  Kyoto University, Department of Synthetic Chemistry and Biological Chemistry, Associate Professor, 大学院・工学研究科, 助教授 (90201285)
Project Period (FY) 1997 – 2000
KeywordsSaccharide chain synthesis / Aggregate of molecules / Control of biomolecules / Control of cell functions / Saccharide chain recognition / Glycopolymer / Functional polysaccharide / Biofunctional saccharide chain
Research Abstract

(1) 7 simposiums had been held.
(2) Research results of each investigator were concluded.
(3) Research results of each group (A01 : basic research on superfine synthesis of saccharide chain ; A02 : aggregate of saccharide chain ; A03 : control of biomolecules by saccharide chain ; A04 : control of cell functions by cognitive multidimensional glyco-chain) were concluded.
(4) Results of all the researchs includins cooperative researchs were concluded to produce a booklet written in English (316 pages).
(5) Research results were published (946 original papers, 187 reviews, more than 1000 oral presentations, 121 books).
(6) The book of "Design of Glyco-Molecules and Their Biological Functions" was edited.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] K.-J.Jeon, T.Uryu et al.: "NMR Spectroscopic Detection of Interactions between a HIV Protein Sequence and a Highly Anti-HIV Active Curdlan Sulfate"J.Am.Chem.Soc.. 122. 12536-12541 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Matsuura, M.Kiso, K. Kitajima, K.Kobayashi et al.: "A Quantitative Estimation of Carbohydrate-Carbohydrate Interaction Using Clustered Oligosaccharide Chains of Glycolipid Monolayers by Surface Plasmon"J.Am.Chem.Soc.. 122. 7406-7407 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] F.Sallas and S.Nishimura: "Chemo-enzymatic Synthesis of Glycopolymers and Sequential Glycopeptides Bearing Lactosamine and Sialyllewisx Units Pendant Chains"J.Chem.Soc., Perkin Trans. 1. 2000. 2091-2103 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Nakamura, K.Furukawa et al.: "Differential gene expression of β-1,4-galactosyltransferases I, II and V during mouse brain development"J.Neurochem.. 76. 29-38 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Akiyoshi, J.Sunamoto et al.: "Controlled Association of Amphiphilic Polymers in Water ; Thermosensitive Nanopart-icles formed by Self-assembly of Hydrophobically Modified Pullulan"Macromolecules. 33. 3244-3249 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Kunou, K.Hatanaka et al.: "Synthesis of Sulfated Colominic Acid and Their Interaction with Fibroblast Growth Factors"Biomacromolecules. 1. 451-458 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Uryu, K.Katsuraya, K.-J.Jean. and Y.Gao: "Hydrocolloids, Part 2 : Biological and Pharmaceutical Activities of Sulfated Poly-and Oligo-saccharides, Ed.K.Nishinari"Elsevier. 487 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Furukawa, N.Kitamura, T.Sato. and S.Hiraizumi: "The Molecular Immunology of Complex Carbohydrates 2"Plenum Press, New York. 480 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.-J.Jeon, K.Katsuraya, T.Inazu, Y.Kaneko, T.Mimura, and T.Uryu: "NMR Spectroscopic Detection of Interactions between a HIV Protein Sequence and a Highly Anti-HIV Active Curdlan Sulfate"J.Am.Chem.Soc.. 122. 12536-12541 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Matsuura, H.Kitakouji, N.Sawada, H.Ishida, M.Kiso, K.Kitajima, and K.Kobayashi: "A Quantitative Estimation of Carbohydrate-Carbohydrate Interaction Using Clustered Oligosaccharide Chains of Glycolipid Monolayers and of Artificial Glycoconjugate Polymers by Surface Plasmon Resonance"J.Am.Chem.Soc.. 122. 7406-7407 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] F.Sallas and S.-I.Nishimura: "Chemo-Enzymatic Synthesis of Glycopolymers and Sequential Glycopeptides Bearing Lactosamine and Sialyl Lewis x Units Pendant Chains"J.Chem.Soc., Perkin Trans.. 1, 2000. 2091-2103 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Nakamura, N.Yamakawa, T.Sato, H.Tojo, C.Tachi, and K.Furukawa: "Differential Gene Expression of β-1,4-Galactosyltransferases I, II and V during Mouse Brain Development"J.Neurochem.. 76. 29-38 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Akiyoshi, E.-C.Kang, S.Kurumada, J.Sunamoto, T.Principi, F.M.Winnik: "Controlled Association of Amphiphilic Polymers in Water ; Thermosensitive Nanoparticles Formed by Self-Assembly of Hydrophobically Modified Pullulan and PolyNIPAM"Macromolecules. 33. 3244-3249 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Kunou, M.Koizumi, K.Shimizu, M.Kawase, and K.Hatanaka: "Synthesis of Sulfated Colominic Acid and Their Interaction with Fibroblast Growth Factors"Biomacromolecules. 1. 451-458 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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