1999 Fiscal Year Final Research Report Summary
T Cell Response with Stress Proteins
| Project/Area Number |
09470067
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
SATO Noriyuki Sch of Med, Sapporo Medical University, 医学部, 教授 (50158937)
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| Project Period (FY) |
1997 – 1999
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| Keywords | hsp70 / molecular chaperones / T cells / antigenic peptides / polyamines / MHC class I / TAP / rat TCR Vδ6 |
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| Research Abstract |
Our study indicated the important role of the 70 kA heat shock proteins (hsp70) for feeding the major histocompatibility antigen complexes (MHC) class I-bound antigenic peptides to the transporters associated with the antigen processing (TAP), and revealed a novel possibility that the repertoire of MHC class I-bound peptides may be limited, at least in part, in the cytosol by their affinity to molecular chaperone hsp70. We also indicated an involvement of polyamines in the interaction between hsp70 and TAP, suggesting the possible role of polyamines in the tumor escape mechanisms.
It was also suggested that some form of hsp70 is expressed on the cell surface with as yet unknown mechanism. Our current data support the notion that an hsp70-like molecule could be presented together with the cellular peptides antigens to particular T cells with the T-cell receptor (TCR) γδ chains. Since the expression of this hsp70-like molecule on the cell surface is usually induced along with cell transformation by activated oncogenes, it is likely that T cells with the TCR Vδ6 family contribute to the host's resistance to tumor cells.
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[Publications] Kamuguchi, K., Torigoe, T., Fujiwara, O., Hirohashi, Y., Sahara, H., I, Sato, N.: "73 kD heat shock cognate protein is associated with transporters associated with antigen processing (TAP) and involved in feeding of MHV vlass I-presentable antigenic peptides to TAP."J. Exp. Med.. in press.
Description
「研究成果報告書概要(和文)」より
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[Publications] Hatamoto, K., Torigoe, T., Mano, Y., Asai, Y., Sato, N.: "Transduction of TAT fusion protein disrupts the interaction between retinoblastoma protein and 70 kD heat shock protein in cells, leading to growth acceleration"Cell Growth Different. in press.
Description
「研究成果報告書概要(和文)」より
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[Publications] Matsuura, A., Kinebuchi, M., Kikuchi, K., Sato, N., et al.: "NK T cell in the rat : organ-specific distribution on NK T cells expressing distinct Val4 chains"J. Immunol. , March,2000. (2000)
Description
「研究成果報告書概要(和文)」より
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[Publications] Nagata, M., Akazawa, T., Tamura, Y., Sagae, S., Kudo, R., Sato, N. et al: "The expression of a novel natural killer inhibitory molecule, Cho-1, on the chorionic cytotrophoblast cells of successful pregnancy, but not of spontaneous abortion"Clin. Exp. Immunol.. in press.
Description
「研究成果報告書概要(和文)」より
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[Publications] Maeda, A., Ohguro, H., Maeda, T., Sato, N., Kuroki, Y., Nakagawa, T. et al.: "Aberrant expression of photoreceptor specific calcium binding protein (recoverin) in cancer cell lines"Cancer. Res. , April, 2000. (2000)
Description
「研究成果報告書概要(和文)」より
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[Publications] Suzuki, K., Sahara, H., Okada, Y., Hirata, K., Kikuchi, K., Sato, N., et al: "Identification of natural antigenic peptides of a human gastric signet ring cell caricinoma recognized by HLA-A31-restricted cytotoic T lymphocytes"J. Immunol.. 163. 2783-2791 (1999)
Description
「研究成果報告書概要(和文)」より
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[Publications] Sato, N., Okada, Y., Suzuki, K., Wada, Y., Hirata, K., Kikuchi, K., et al: "Gann Monogro. Jap. J. Cancer Res."Natural antigenic peptides of gastric signet ring cell carcinomas. 10 (1999)
Description
「研究成果報告書概要(和文)」より
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[Publications] Kamuguchi,K., Torigoe,T., Fujiwara,O., Hirohashi,Y., Sahara,H., Hiraii,I., Sato,N.: "73 kD heat shock cognate protein is associated with transporters associated with antigen processing (TAP) and involved in feeding of MHV vlass I-presentable antigenic peptides to TAP"J. Exp. Med.. in press.
Description
「研究成果報告書概要(欧文)」より
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[Publications] Hatamoto,K., Torigoe,T., Mano,Y., Asai,Y., Sato,N.: "Transduction of TAT fusion protein disrupts the interaction between retinoblastoma protein and 70 kD heat shock protein in cells, leading to growth acceleration."Cell Growth Different. in press.
Description
「研究成果報告書概要(欧文)」より
-
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[Publications] Nagata,M., Akazawa,T., Tamura,T., Sagae,S., Kudo,R., Sato,N.: "The expression of a novel natural killer inhibitory molecule, Cho-1, on the chorionic cytotrophoblast cells of successful pregnancy, but not of spontaneous abortion."Clin. Exp. Immunol.. in press.
Description
「研究成果報告書概要(欧文)」より
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[Publications] Maeda,A., Ohguro,H., Maeda,T., Sato,N., Kuroki,Y., Nakagawa,T.: "Aberrant expression of photoreceptor specific calcium binding protein (recoverin) in cancer cell lines."Cancer. Res.,. (2000)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Suzuki,K., Sahara,H., Okada,Y., Hirata,K., Kikuchi,K., Sato,N.: "Identification of natural antigenic peptides of a human gastric signet ring cell carcinoma recognized by HLA-A31-restricted cytotoic T lymphocytes."J. Immunol.. 163. 2783-2791 (1999)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Sato,N., Okada,Y., Suzuki,K., Wada,Y., Hirata,K., Kikuchi,K.: "Natural antigenic peptides of gastric signet ring cell carcinomas"Gann Monogr. Jap. J. Cancer Res.. 48. 31-41 (1999)
Description
「研究成果報告書概要(欧文)」より
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