1999 Fiscal Year Final Research Report Summary
Development of a small diameter vascular prosthesis foro coronary artery bypass grafting with a capacity of collateral formation due to angiogenesis because of endogenous cytokines
| Project/Area Number |
09470287
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
ENDO Masahiro Tokyo Women's Medical University, Dept. of Cardiovascular Surgery Professor, 医学部, 教授 (20075302)
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| Co-Investigator(Kenkyū-buntansha) |
TOMIZAWA Yasuko Tokyo Women's Medical University, Dept. of Cardiovascular Surgery Instructor, 医学部, 助手 (00159047)
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| Project Period (FY) |
1997 – 1999
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| Keywords | Small diameter vascular prosthesis / Graft / Endogenous / Cytokines / Endothelialization / CABG / Collateral formation / endogenous |
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| Research Abstract |
Antithrombogenicity is one of the most important factors for development of small diameter vascular prosthesis in the coronary artery position. To obtain permanent anthrombogenicity, rapid endothelialization is important for conduits for coronary artery bypass grafting (CABG). Endogenous cytokines including basic fibroblast growth factor (bFGF) works for angiogenesis. Tissue fragmented vascular grafts were developed using autologous connective tissue. From vaso vasorum, endothelialization started on the lumen. From the fragments, production of endogenous cytokines was expected. Angiogenesis was also studied in a rabbit ear chamber model in this term. Angiogenesis occurred from venous side. With endogenous cytokines, it took 3 weeks for 3 mm in the chamber. It was concluded that angiogenesis due to endogenous cytokines may work for treatment of ischemic heart disease, as endothelialization of bypass graft, and as collateral formation.
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