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1999 Fiscal Year Final Research Report Summary

Prediction of durability of artificial organs using an accerelated fatigue tester

Research Project

Project/Area Number 09470288
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionWaseda University

Principal Investigator

UMEZU Mitsuo  Waseda University, School of Science and Engineeing, Professor, 理工学部, 教授 (90132927)

Co-Investigator(Kenkyū-buntansha) AKUTSU Toshinosuke  Kanto Gakuin University, School of Engineering, Professor, 工学部, 教授 (90231852)
KITAMURA Nobuo  Kyoto Prefectural University of Medicine, School of Medicine, Professor, 医学部, 教授 (70075513)
KAWAZOE Kohei  Iwate Medical College, School of Medidne, Professor, 医学部, 教授 (50075561)
UCHIYAMA Akihiko  Waseda University, School of Science and Engineering, Professor, 理工学部, 教授 (50063615)
FUJIMOTO Tetsuo  Waseda University, Advanced Research Inst for Sci.and Eng.Assoc.Professor, 理工学総合研究センター, 助教授 (50267473)
Project Period (FY) 1997 – 1999
Keywordsaccerelated fatigue tester / ISO standard / Polymer valve / Jellyfish valve / FEM / load / temerature / fracture
Research Abstract

In order to predict a durability of heart valve prostheses, two types of commercially available (ISU-Standard) accerelated fatigue tests were employed, while improving a life time of Jellyfish polymer valve.
A chronic animal experiment of Jellyfish valves incorporated into conventional sac-type blood pumps for over 300days exhibited that there were a fracture and calcification on this flexible membrane. Therefore, a long durability (approx. 1 year guarantee) of Jellyfish valve has been developing. while clearing a cause of the problems.
First of all, design improvement of Jellyfish valve was attempted. Results of finite element analysis during closed phase of Jellyfish valve indicated that mechanical strain generated on valve membrane fracture and calcification in the animal experiment. Moreover further analysis suggested that an additional circular rim located at 7.0mm in radius was quite effective to avoid strain concentration. In vitro steady and pulsatile tests demonstrated that a modified valve with 0.5mm width rim located at 70mm in radius had a comparable hydrodynamic performance to the original Jellyfish valve.
For the next step, commercially available two types of accelerated fatigue tests were employed. Fatigue tests successfully revealed that a durability of the modified valve was much more extended than the original Jellyfish valve by 7 times.
Thus, chronic animal experiment with conventional sac-type blood pumps in which the modified valves were incorporated was performed for months. Hemolysis related to the application of the modified valve was not observed. This would be owing to the tapered configuration of the additional rim with 0.1mm width of inflow side.
From the data above, the modified polymer valve showed great promise for clinical artificial heart application, and it was also clarified that our prevent fatigue tester could provide comparative durability data of polymer valves.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] M.Umezu: "Application of rotational moulding for the development of artificial organs"Rotation (The magazine of the Int.Rotation Molding Industry). 7(3). 24-31 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩崎清隆,梅津光生 他: "医療用高分子材料の疲労が血液適合性に与える影響の検討"第14回ライフサポート学会講演予稿集. 106-107 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Iwasaki, M.Umezu, et al.: "Development of a durable polymer valve based on finete element analysis"APCMBE, Proc.. 252 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩崎清隆,梅津光生 他: "高分子製人工弁の加速耐久試験確立に向けての力学的検討"人工臓器. (掲載予定). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Umezu: "Development of a mechanical circulatory simulator to evaluate hemodynamics of artificial organs"9^<th> International Conference on Biomedical Engineering. 3(6). 153-155 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Umezu, T.Fujimoto, et al.: "Three types of in-vitro evaluation test system for blood pump performance"Proc.Of 4^<th> Int.Conf.on BME. 1-2 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Umezu: "Mock circulatory system (in Japanese)"SICE. 38(5). 312-316 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Fujimoto, M.Umezu, et al.: "Effects of cardiac function on an arterial vascular graft implantation"Artif Organs. 23(7). 685 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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