1998 Fiscal Year Final Research Report Summary
Growth factor of hair cell regeneration in auditory epithelium and cochlear nucleus
| Project/Area Number |
09671775
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
SAKAGAMI Masafumi Hyogo College of Medicine Professor, 医学部, 教授 (10170573)
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| Co-Investigator(Kenkyū-buntansha) |
UMEMOTO Masanori Hyogo College of Medicine Instructor, 医学部, 助手 (30309471)
AKIRA Shizuo Hyogo College of Medicine Professor, 医学部, 教授 (50192919)
SEO Toru Hyogo College of Medicine Assistant Professor, 医学部, 講師 (30258149)
FUKAZAWA Keijiro Hyogo College of Medicine Assistant Professor, 医学部, 講師 (50278842)
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| Project Period (FY) |
1997 – 1998
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| Keywords | auditory epithelium / cochlear nucleus / regeneration / growth factor / adhesion molecule / genesis / acoustic trauma |
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| Research Abstract |
Growth factors and adhesion molecules of embryogenesis and regeneration, because both are similar in auditory epithelium. By immunohistochemistry neurite growth factor (NOF) was expressed in acoustic ganglion and basal membrane at gestational and immmature stages. New adhesion molecule, gicerin, was expressed in auditory epithelium and acoustic ganglion at immature stage, and in the area of active cell proliferation of regenerative epithelium after acoustic trauma. Gicerin may be associated with cell proliferation in the auditory epithelium, and play a role in neurite extension of the acoustic ganglion cells in conjunction with NOF.
Highly polysialylated neural adhesion molecule (NCAM-H) was observed in nerve fibers of auditory epithelium and acoustic ganglion at gestational stage. It was also observed at acoustic ganglion after birth. It is suggested that NCAM-H specifically regulates the afferent nerve fibers' growthand synaptogenesis with hair cells during inner ear development and may be associated with neuronal plasticity.
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