1999 Fiscal Year Final Research Report Summary
Novel synthesis of indole derivatives based on the palladium catalyzed cross-coupling reaction with indolylborates as a key reaction
| Project/Area Number |
09672151
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
ISHIKURA Minoru Health Sciences University of Hokkaido, Faculty of Pharmaceutical Sciences, associate Prof., 薬学部, 助教授 (10146011)
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| Co-Investigator(Kenkyū-buntansha) |
KATAGIRI Nobuya Health Sciences University of Hokkaido, Faculty of Pharmaceutical Sciences, Prof., 薬学部, 教授 (60089787)
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| Project Period (FY) |
1997 – 1999
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| Keywords | indolylborate / indole / borate / cross-coupling reaction / ellipticine / yuehchukene |
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| Research Abstract |
Indolylborates, readily available from the corresponding 2-lithioindoles and triethylborane in situ, are valuable synthetic intermediates, and the development of their synthetic capabilities has been our continuing interest. During these studies, the palladium catalyzed cross-coupling reaction with indolylborates has been proven to be an effective protocol for the preparation of substituted indole derivatives. In these studies, the followings have been achieved by the use of the cross-coupling reaction as a key reaction;
1. Synthesis of ellipticine and its analogues by the palladium catalyzed tandem cyclization cross-coupling reaction
2. Synthesis of yuehchukene and its analogues by the palladium catalyzed carbonylative cross-coupling reaction.
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