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1998 Fiscal Year Final Research Report Summary

Genetical and pathogenic study of new parainfluenza virus 3 derived from guinea pig.

Research Project

Project/Area Number 09680831
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionNagasaki University

Principal Investigator

SATO Hiroshi  Nagasaki University, School of Medecine, Associate Professor, 医学部, 助教授 (50072947)

Co-Investigator(Kenkyū-buntansha) KISHIKAWA Masao  Colony of Handycapped People, Research Inst. of Development, Chief Director, 究所, 部長 (80112374)
Project Period (FY) 1997 – 1998
KeywordsParainfluenza virus / Guinea pigs / Virus genome / Zoonosis / Infection experiment
Research Abstract

Parainfluenza 3 virus derived from guineapig(GPIV3) in which we isolated for the first time was carried out for genetic comparison and pathogenicity to the rodents. Following results were obtained.
1. Nucleotide difference found between the coding regions of the genomes of GPIV-3 and human PIV-3(WA strain) was 3.8% - 6.5% while that between GPIV-3 and human PIV-3(JS strain) was 2.1% - 4.4%. Difference in the nucleotide sequence(20.4% - 29.0%) between GPIV-3 and bovine PIV-3, indicated that GPIV-3 was more closely related with HPIV3s than BPIV3.
2. The result of phylogenetic analysis using NJ and UPGMA methods clearly showed that GPIV-3 was a lineage of human PIV-3.
3. These results suggested that GPIV-3 had been probably introduced into guinea pig colonies via infected human.
4. Infection experiments revealed that virus genome could be detected in pulmonary of guineapig and rats at least for 10 days after virus inoculation. Although the consolidation was demonstrated in lungs, precise examination should be continuously followed.

  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] Kazutaka Ohsawa: "Genetic chracterizaion of Parainfluenza virus 3 derived from guines pigs"J. Vet. Med. Sci.. 60(8). 919-922 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kazutaka Ohsawa: "Genetic characterization of parainfluenza virus 3 derived from guinea pigs"J. Vet. Med. Sci.. 60(8). 919-922 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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