2001 Fiscal Year Final Research Report Summary
Basic Research for AIDS control
| Project/Area Number |
10180103
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| Research Category |
特定領域研究
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
UCHIYAMA Takashi Kyoto University, Graduate School of Medicine, professor, 医学研究科, 教授 (80151900)
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| Co-Investigator(Kenkyū-buntansha) |
MITUYA Yoshiaki Kumamoto University, Faculty of Medicine, Professor, 医学部, 教授 (20136724)
MATSUSHITA Shuzo Kumamoto University, Center for AIDS Research, Professor, エイズ学研究センター, 教授 (00199788)
KOYANAGI Yoshio Tohoku University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (80215417)
HORI Toshiyuki Kyoto University, Graduate School of Medicine, Lecturer, 医学研究科, 講師 (70243102)
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| Project Period (FY) |
2002
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| Keywords | HIV-1 / Host Factors / Pathophysiology / Immune response / AIDS Control / Chemokine / Chemokine Receptor |
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| Research Abstract |
This research project focused on AIDS control, had been done for 4 years from 1998 to 2001, and divided into three major groups which had their own goals. These are as follows ; A01 : Host factors necessary for HIV-1 replication, in which we intended to better understand the viral life cycle by identifying host factors necessary for HIV-1 replication and elucidating their interaction with the virus. A02 : Pathophysiology and immunology of HIV-1 infection, in which we tried to elucidate the mechanism of immune response to HIV-1, establishment of persistent infection, and destruction of immune system in infected individuals. A03 : Prevention and control of AIDS, in which we pursued to establish a novel therapeutic strategy targeted to each step of the viral life cycle as well as to elucidate the mechanism of drug resistance of HIV-1. We had been worked from these three major aspects and got 4 major research results as follows. 1) Studies on chemokine and chemokine receptors. 2) Host factors which bind to tat protein to regulate the viral transcription. 3) Specific immune response to HIV-1 mainly focusing on HIV-1-specific CTL response and basic research for vaccine development. 4) Analysis of pathophysiology of HIV-1 infection and pathogenic factors using unique animal models. Among them, 1) studies on chemokine and chemokine receptors were the most important issue of this project and done by many investigators across the subgroups intensively, resulting in the major progress in this field including the elucidation of the detailed mechanism of viral entry through chemokine receptors, development of a novel treatment targeted for chemokine receptors, genetic analysis of polymorphism of chemokine/chemokine receptors affecting progression of AIDS. These results were outstanding worldwide.
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