1999 Fiscal Year Final Research Report Summary
Physiologic and pathologic functions of a CXC chemokine PBSF/SDF-1 and its receptor CXCR4
| Project/Area Number |
10470092
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Research Institute, Osaka Medical Center for Maternal and Child Health |
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Principal Investigator |
NAGASAWA Takashi Research Institute, Osaka Medical Center for Maternal and Child Health, Department of medical immunity, Lab.head, 免疫部門, 部長 (80281690)
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| Project Period (FY) |
1998 – 1999
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| Keywords | chemokine / bone marrow / B lymphocyte / hematopoiesis / homing / angiogenesis |
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| Research Abstract |
Chemokines are a family of small structurally related molecules that were recognized originally for their ability to regulate cell trafficking in inflammation. We isolated a chemokine, stromal cell-derived factor/pre-B-cell growth stimulating factor (SDF-1/PBSF) as a molecule that stimulates the growth of B lymphocyte precursors and have found its multiple physiological functions in development. We have shown that SDF-1/PBSF is essential for embryonic viability, development of B lymphocyte, colonization of bone marrow by hematopoietic cells and cardiogenesis. Moreover, we identified a murine seven-transmembrane G-protein-coupled receptor for SDF-1/PBSF, termed CXCR4, that also functions as a coreceptor for strains of HIV-1. Here we generated CXCR4 deficient mice and found that CXCR4 was a primary physiologic receptor for SDF-1/PBSF.
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