• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2000 Fiscal Year Final Research Report Summary

Influence of habitual exercise and circumstantial stresses on non-specific immunity and oxidant-antioxidant balance

Research Project

Project/Area Number 10470101
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionNational Institute of Public Health

Principal Investigator

KUMAE Takashi  Industrial Health, National Institute of Public Health, Chief, 労働衛生学部, 室長 (40145363)

Co-Investigator(Kenkyū-buntansha) ARAKAWA Hatsuko  Industrial Health, National Institute of Public Health, Senior Research Officer, 労働衛生学部, 主任研究員 (90222736)
UCHIYAMA Iwao  Industrial Health, National Institute of Public Health, Director, 労働衛生学部, 部長 (20151897)
Project Period (FY) 1998 – 2000
Keywordsnon-specific immunity / reactive oxygen species / antioxidant / stress / exercise / maturation / chemiluminescence / phagocyte
Research Abstract

We presented the results of basic research using rats as an experimental animal at many scientific congresses. The stresses, forced or voluntary exercise, sleep disturbance, and isolation, were loaded to mature rats. The forced and voluntary exercise influenced body weights, however, the producing ability of reactive oxygen species (ROS) from alveolar macrophages was almost not affected by the stresses. ROS was measured by a parallel luminescent measuring system using a 96-well microplate. To develop an index to measure alveolar macrophage activity, the system was remodeled for fluorescence measurement. There were few significant differences among the stress groups on the oxidant-antioxidant balance in mitochondrial and microsomal fractions of rat lungs. These results suggest that non-specific immunity and oxidant-antioxidant balance in lungs are resistant to the stresses loaded after maturation.
To clarify the subjects' circumstances toward forced or voluntary, we surveyed the health, … More psychological, and food-intake statuses in athletes and reported the results to the scientific journals. The effect of endurance training during a 1-month summer camp on the non-specific immunity was investigated and published in Int. J.Sports Med. The results suggest that the non-specific immunity is not directly impaired by the summer camp. The cytotoxic activities of natural killer cells of joggers were not affected by endurance running during a month-long distance run competition. A measurement method for a total antioxidant activity of serum was established to estimate the in vivo oxidant-antioxidant balance and we reported the mechanistic approach and application of the serum total antioxidant activity. The serum total antioxidant activity is a trapping capacity of ROS.The influence of daily-exercise on the oxidant-antioxidant balance of aged residents (over 65 years old) was estimated by serum, however, no significant influence of daily-exeercise was observed. Intensity of daily-exercise may be too low to affect the oxidant-antioxidant balance. Less

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Kumae,T.: "Development of a new simple estimating method for protein, fat, and carbohydrate in cooked foods."Environ.Health Preven.Med.. 4巻. 205-211 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kumae,T.& Kawahara,T: "Effects of endurance running during one month on the cytotoxic activity of natural killer cells and the phagocytic reactive oxygen species production from neutrophils."J.Phys.Fit.Nutr.Immunol.. 10巻1号. 7-14 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kumae,T.: "A study of the fluorescence measurement using a 96-well microplate by a remodeled parallel luminescent measuring system."Luminescence. 14巻. 375-381 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kumae,T.,Yamasaki,K.,shizaki.K.,& Ito,T.: "Effects of endurance training during summer camp on non-specific immunity in long-distance runners."Int.J.Sports Med.. 20巻. 390-395 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kumae,T.,Kurakake,S.,Arakawa,H.,Uchiyama,I.: "A study for prevention of chronic fatigue. Part 2. Effects of strenuous physical exercise performed in a training camp on serum enzyme activity levels and subjective fatigue."Environ.Health Prevent.Med.. 3巻. 89-95 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 熊江隆: "生理的疲労のメカニズムと回復.疲労感の変動とその評価."臨床スポーツ医学. 17巻7号. 801-806 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 熊江隆: "免疫機能の変動.スポーツ医科学.(編)中野昭一"杏林書院,東京.. 309-327 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kumae T.: "A study for reactive oxygen species production from neutrophils in the mouth. Biolumi-nescence and Chemiluminescence. (Eds) A Roda. M Pazzagli, L J Kricka & P E Stanley"John Wiley & Sons, West Sussex.. 273-276 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kumae, T.: "Development of a new simple estimating method for protein, fat, and carbohydrate in cooked foods."Environ. Health Prevent. Med.. 4. 205-211 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kumae, T.& Kawahara, T.: "Effects of endurance running during one month on the cytotoxic activity of natural killer cells and the phagocytic reactive oxygen species production from neutrophils."J.Phys. Fit. Nutr. Immunol.. 10. 7-14 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kumae, T.: "A study of the fluorescence measurement using a 96-well microplate by a remodeled parallel luminescent measuring system."Luminescence. 14. 375-381 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kumae, T., Yamasaki, K., Ishizaki, K.& Ito, T.: "Effects of endurance training during summer camp on non-specific immunity in long- distance runners."Int. J.Sports Med.. 20. 390-395 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sugawara K, Suzuki K, Liu Q, Umeda T, Shimoyama T, Nakaji S, Kugoh S, Yamada M, Kowatari K, Suzuki K, & Kumae T: "Production of reactive oxygen species from human neutrophils in many kinds of environment."Hirosaki Med. J.. 51. S31-S42 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kumae, T.: "A study for reactive oxygen species production from neutrophils in the mouth. Bioluminescence and Chemiluminescence (Eds) Roda A, Pazzagli M, Kricka LJ, Stanley PE."John Wiley & Sons West Sussex. 273-276 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kumae, T., Kurakake, S., Arakawa, H., & Uchiyama, I.: "A study for prevention of chronic fatigue. Part 2. Effects of stenuous physical exercise performed in a training camp on serum enzyme activity levels and subjective fatigue."Environ. Health Prevent. Med.. 3. 89-95 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Arakawa, H.& Kumae T.: "Aging effects on tissue weights and cell populations in bronchoalveolar lavage fluids in Brown-Norway rats."J.Phys. Fit. Nutr. Immunol. 8. 78-86 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2002-03-26  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi