1999 Fiscal Year Annual Research Report

肝細胞癌の発生・進展における腫瘍血管構築の分子機構と血流画像

Research Project

Project/Area Number	10470143
Research Institution	Kinki University
Principal Investigator	工藤正俊近畿大学, 医学部・附属病院, 教授 (10298953)
Keywords	肝細胞癌 / 腫瘍血管 / 血管新生 / 血流動態 / 多中心性発癌 / ハーモニックイメージング
Research Abstract	1.分子生物学的解析肝細胞癌の多発結節が多中心性発癌(MO)によるものか肝内転移(IM)によるものかをB型肝癌において検討した。方法は手術的に得られたパラフィン包埋切片もしくは新鮮凍結標本について多発癌におけるB型肝炎ウィルスの組み込みをSowthern blottingにより検討した。異時性のものについて1個がパラフィン包埋でしか残っていないものについても、新鮮標本から得られたHBUDNAの組み込み部分のクローニングにより検討した。その結果、切除の対象となるような小型のB型肝癌のほとんどがMOによることが明らかとなった。 2.血流動態的解析新しく導入された静注用超音波造影剤を用いることにより、癌性血洞レベルの血流表示もハーモニックエコー法で可能であることが明らかとなった。

Research Products

(11 results)

All Other

All Publications (11 results)

[Publications] Tochio H,Kudo M,et al: "Assciation between a focal spared area in the fatty liver and intrahepatic efferent blood flow from the gall bladder"AJR. 172. 1249-1253 (1999)
[Publications] Yamamoto T,Kudo M,et al: "Determination of the clonal origin of mulfiple human hepatocellular carcinomas by cloning and PCR of the integrated hepatitis B virus DNA."Hepatology. 29. 1446-1452 (1999)
[Publications] Marusawa,Kudo M,et al: "High prevalence of hepatitis B virus serological markers in patients with hepatitis C virus related chronic liver ***arse in Japan"Gut. 45. 284-288 (1999)
[Publications] Kudo M: "Imaging diagnosis of hepatocellular carcinona and premalignant/borderline lesions."Sewinors in Liver Disease. 19. 297-309 (1999)
[Publications] Watanabe T,Kudo M,et al: "Cronkhite-Canada syndrome associated with triple gastric cansers"Gastrointest Endoscopy. 50. 688-691 (1999)
[Publications] Watanabe T,Kudo M,et al: "Massire rectal bleeding due to ileal tuberculosis"J Gastroenterol. 34. 525-529 (1999)
[Publications] Kim SR,Kudo M,et al: "Inflammatory psendotumor of the liven in patient with chronil hepatitis C"Pathology International. 49. 726-730 (1999)
[Publications] Kudo M: "Riedel's lobe of the liver and its clinical impliction"Internal Medicine. 39. 87-88 (2000)
[Publications] Kim SR,Kudo M,et al: "A case of hepatocellular carcinona transforming from adenomatous hyperplasia in three years"Intervirology. (in press).
[Publications] Kim SR,Kudo M,et al: "A case of hepatocellular carcinona transforming from dysplastic nodule with background of non-B non-C chronic persistent hepatitis."J Hepatology. (in press).
[Publications] Nakaoka R,Kudo M,et al: "Repeated hepatic arterial chemoembolization therapy for management of a patient with wetastatic carcinold fumors of the liver."Am J Gastroenterol. (in press).

1999 Fiscal Year Annual Research Report

肝細胞癌の発生・進展における腫瘍血管構築の分子機構と血流画像

Principal Investigator

工藤 正俊 近畿大学, 医学部・附属病院, 教授 (10298953)

Research Products

[Publications] Tochio H,Kudo M,et al: "Assciation between a focal spared area in the fatty liver and intrahepatic efferent blood flow from the gall bladder"AJR. 172. 1249-1253 (1999)

[Publications] Yamamoto T,Kudo M,et al: "Determination of the clonal origin of mulfiple human hepatocellular carcinomas by cloning and PCR of the integrated hepatitis B virus DNA."Hepatology. 29. 1446-1452 (1999)

[Publications] Marusawa,Kudo M,et al: "High prevalence of hepatitis B virus serological markers in patients with hepatitis C virus related chronic liver ***arse in Japan"Gut. 45. 284-288 (1999)

[Publications] Kudo M: "Imaging diagnosis of hepatocellular carcinona and premalignant/borderline lesions."Sewinors in Liver Disease. 19. 297-309 (1999)

[Publications] Watanabe T,Kudo M,et al: "Cronkhite-Canada syndrome associated with triple gastric cansers"Gastrointest Endoscopy. 50. 688-691 (1999)

[Publications] Watanabe T,Kudo M,et al: "Massire rectal bleeding due to ileal tuberculosis"J Gastroenterol. 34. 525-529 (1999)

[Publications] Kim SR,Kudo M,et al: "Inflammatory psendotumor of the liven in patient with chronil hepatitis C"Pathology International. 49. 726-730 (1999)

[Publications] Kudo M: "Riedel's lobe of the liver and its clinical impliction"Internal Medicine. 39. 87-88 (2000)

[Publications] Kim SR,Kudo M,et al: "A case of hepatocellular carcinona transforming from adenomatous hyperplasia in three years"Intervirology. (in press).

[Publications] Kim SR,Kudo M,et al: "A case of hepatocellular carcinona transforming from dysplastic nodule with background of non-B non-C chronic persistent hepatitis."J Hepatology. (in press).

[Publications] Nakaoka R,Kudo M,et al: "Repeated hepatic arterial chemoembolization therapy for management of a patient with wetastatic carcinold fumors of the liver."Am J Gastroenterol. (in press).

工藤正俊近畿大学, 医学部・附属病院, 教授 (10298953)