2000 Fiscal Year Annual Research Report

肝細胞癌の発生・進展における腫瘍血管構築の分子機構と血流画像

Research Project

Project/Area Number	10470143
Research Institution	Kinki University School of Medicine
Principal Investigator	工藤正俊近畿大学, 医学部・附属病院, 教授 (10298953)
Keywords	肝細胞癌 / 腫瘍血管 / 血管新生 / 血流動態 / 多中心性発癌 / ハーモニックイメージング / 血管構築 / 血管新生因子
Research Abstract	1.肝細胞癌の発癌進展に伴う血流動態の変化肝細胞癌の発癌初期には結節は過形成として発癌して発癌するが、動脈血流は低下し門脈血流は保たれることを示した。その後、動脈も門脈も低下する時期を経て動脈性腫瘍血管の新生が誘導されて典型的な動脈優位の肝細胞癌へと発育・進展することをinvivo血流イメージングにより示した。またその変化は病理学的進展、あるいは分子生物学的な血管新生因子の誘導ともよく一致した。 2.血流画像的解析超音波造影剤を用いてハーモニックイメージを行うことにより、上記の血流動態の推移も容易に把握しうることを示した。

Research Products

(29 results)

All Other

All Publications (29 results)

[Publications] Kudo M: "Morphological diagnosis of hepatocellular carcinoma : special emphais on intranodular hemodynamic imaging."Hepato-Gastroenterology. 45. 1226-1231 (1998)
[Publications] Yamamoto T,Kudo M, et al.: "Hepatocellular carcinomas infected with the novel TT DNA virus lack viral integration."Biochem Bioph Res Co. 251. 339-343 (1998)
[Publications] Kim SR,Kudo M, et al.: "A case of well-differentiated minute hepatocellular carcinoma with extrahepatic metastasis."J Gastroenterol Hepatol. 13. 892-896 (1998)
[Publications] Watanabe T,Kudo M, et al.: "Detection of Helicobacter Pylori gene using immunomagnetic separation based PCR from feces."Scand J Gastroenterol. 11. 1140-1143 (1998)
[Publications] Tochio H,Kudo M, et al.: "Association between a focal spared area in the fatty liver and intrahepatic efferent blood flow from the gallbladder wall"AJR. 172. 1249-1253 (1999)
[Publications] Yamamoto T,Kudo M, et al.: "Determination of the clonal origin of multiple human hepatocellular carcinomas by cloning and polymerase chain reaction of the integrated hepatitis B virus DNA."Hepatology. 29. 1446-1452 (1999)
[Publications] Kudo M: "Liver Radiological Examination-Ultrasonography (including Biopsy), In "Abdominal and Gastrointestinal Imaging Multimedia Virtual Textbook", Gourtsoyiannis NE."Medic-Online, Euromultimedia S.A., Luxembourg. (1999)
[Publications] Marusawa H,Kudo M, et al.: "High prevalence of hepatitis B virus serological markers in patients with hepatitis C virus related chronic liver disease in Japan."Gut. 45. 284-288 (1999)
[Publications] Kudo M: "Imaging diagnosis of hepatocellular carcinoma and premalignant /borderline lesions."Seminors in Liver Disease. 19. 297-309 (1999)
[Publications] Watanabe T,Kudo M, et al.: "Cronkhite-Canade syndrome associated with triple gastric cancers : report of a case."Gastrointest Endoscopy. 50. 688-691 (1999)
[Publications] Watanabe T,Kudo M, et al.: "Massive rectal bleeding due to ileal tuberculosis."J Gastroenterol. 34. 525-529 (1999)
[Publications] Kim SR,Kudo M, et al.: "Intlammatory pseudotumor of the liver in patient with chronic hepatitis C : Difficulty in differentiating it from hepatocellular carcinoma."Pathology International. 49. 726-730 (1999)
[Publications] Kudo M: "Riedel's lobe of the liver and its clinical implications."Internal Medicine. 39(2). 87-88 (2000)
[Publications] Kim SR,Kudo M, et al.: "A case of hepatocellular carcinoma transforming from adenomatous hyperplasia in three years with the background of non-B non-C, non-TTV chronic persistent hepatitis."Intervirology. 43(7). 13-15 (2000)
[Publications] Nakaoka R,Kudo M, et al: "Repeated hepatic arterial chemoembolization therapy for management of a patient with metastatic carcinoid tumors of the liver."Am J Gastroenterol. 95(7). 1842-1843 (2000)
[Publications] Kim SR,Kudo M, et al.: "Hepatocellular carcinoma transforming from dysplastic nodule with background of non-B non-C chronic persistent hepatitis."Journal of Hepatology. 33. 857-858 (2000)
[Publications] Nomura H,Kudo M, et al.: "Laparoscopic splenopexy for adult wandering spleen : Sandwich method with two sheets of absorbable knitted mesh."Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. 10(5). 332-334 (2000)
[Publications] Kudo M: "Hepatocellular adenoma in type Ia glycogen storage disease."J Gastroenterol. 36. 65-66 (2001)
[Publications] Ding H,Kudo M, et al.: "Contrast-enhanced subtraction harmonic sonography for evaluating treatment response in patients with hepatpcellular carcinoma."AJR.. (in press). (2001)
[Publications] Kawasaki T,Kudo M, et al.: "Vascularity of advanced gastric carcinoma : evaluation by using power Doppler imaging."J Gastroenterol Hepatol 16 :.. 16(in press). (2001)
[Publications] Kim SR,Kudo M, et al.: "A case of disseminated extrahepatic carcinoma after US-guided biopsy and percutaneous ethanol injection therapy."Hepatology Research.. (in press). (2001)
[Publications] Kawasaki T,Kudo M, et al.: "A case of localized primary sclerosing cholangitis mimicking intrahepatic bile duct cancer."Hepatology Research.. (in press). (2001)
[Publications] Ding H,Kudo M, et al.: "Delection of tumor parenchymal flow in hepatocellular carcinoma : utility of intermittent harmonic imaging in the early arterial phase with dual display mode."Radiology.. (in press). (2001)
[Publications] Ding H,Kudo M, et al.: "Diagnosis of pancreatic islet cell tumor : value of intermittent harmonic imaging."JCU.. (in press). (2001)
[Publications] Kudo M: "Hepatic peribiliary cysts : clinically harmless disease with potential risk due to increase in size and number."J Gastroenterol.. (in press). (2001)
[Publications] Kudo M: "Cerebral vascular resistence in hepatic insufficiency."J Gastroenterol Hepatol.. (in press). (2001)
[Publications] Kudo M: "Blood flow characteristics and hepatocellular carcinoma."Oncology.. (in press). (2001)
[Publications] Kudo M: "Advances in diagnostic imaging of hepatocellular carcinoma.In "Hepatology in the 21st Century : Diagnosis and Therapy.""IASL, APASL, and JSH JOINT POST GRADUATE TEXTBOOK. 9 (2000)
[Publications] Kudo M: "Color Doppler observation of efferent blood flow in liver tumors.In Dynamic Study of Efferent Tumor Blood Fow"BRACCO, Italy, 2001 (in press). (2001)

2000 Fiscal Year Annual Research Report

肝細胞癌の発生・進展における腫瘍血管構築の分子機構と血流画像

Principal Investigator

工藤 正俊 近畿大学, 医学部・附属病院, 教授 (10298953)

Research Products

[Publications] Kudo M: "Morphological diagnosis of hepatocellular carcinoma : special emphais on intranodular hemodynamic imaging."Hepato-Gastroenterology. 45. 1226-1231 (1998)

[Publications] Yamamoto T,Kudo M, et al.: "Hepatocellular carcinomas infected with the novel TT DNA virus lack viral integration."Biochem Bioph Res Co. 251. 339-343 (1998)

[Publications] Kim SR,Kudo M, et al.: "A case of well-differentiated minute hepatocellular carcinoma with extrahepatic metastasis."J Gastroenterol Hepatol. 13. 892-896 (1998)

[Publications] Watanabe T,Kudo M, et al.: "Detection of Helicobacter Pylori gene using immunomagnetic separation based PCR from feces."Scand J Gastroenterol. 11. 1140-1143 (1998)

[Publications] Tochio H,Kudo M, et al.: "Association between a focal spared area in the fatty liver and intrahepatic efferent blood flow from the gallbladder wall"AJR. 172. 1249-1253 (1999)

[Publications] Yamamoto T,Kudo M, et al.: "Determination of the clonal origin of multiple human hepatocellular carcinomas by cloning and polymerase chain reaction of the integrated hepatitis B virus DNA."Hepatology. 29. 1446-1452 (1999)

[Publications] Kudo M: "Liver Radiological Examination-Ultrasonography (including Biopsy), In "Abdominal and Gastrointestinal Imaging Multimedia Virtual Textbook", Gourtsoyiannis NE."Medic-Online, Euromultimedia S.A., Luxembourg. (1999)

[Publications] Marusawa H,Kudo M, et al.: "High prevalence of hepatitis B virus serological markers in patients with hepatitis C virus related chronic liver disease in Japan."Gut. 45. 284-288 (1999)

[Publications] Kudo M: "Imaging diagnosis of hepatocellular carcinoma and premalignant /borderline lesions."Seminors in Liver Disease. 19. 297-309 (1999)

[Publications] Watanabe T,Kudo M, et al.: "Cronkhite-Canade syndrome associated with triple gastric cancers : report of a case."Gastrointest Endoscopy. 50. 688-691 (1999)

[Publications] Watanabe T,Kudo M, et al.: "Massive rectal bleeding due to ileal tuberculosis."J Gastroenterol. 34. 525-529 (1999)

[Publications] Kim SR,Kudo M, et al.: "Intlammatory pseudotumor of the liver in patient with chronic hepatitis C : Difficulty in differentiating it from hepatocellular carcinoma."Pathology International. 49. 726-730 (1999)

[Publications] Kudo M: "Riedel's lobe of the liver and its clinical implications."Internal Medicine. 39(2). 87-88 (2000)

[Publications] Kim SR,Kudo M, et al.: "A case of hepatocellular carcinoma transforming from adenomatous hyperplasia in three years with the background of non-B non-C, non-TTV chronic persistent hepatitis."Intervirology. 43(7). 13-15 (2000)

[Publications] Nakaoka R,Kudo M, et al: "Repeated hepatic arterial chemoembolization therapy for management of a patient with metastatic carcinoid tumors of the liver."Am J Gastroenterol. 95(7). 1842-1843 (2000)

[Publications] Kim SR,Kudo M, et al.: "Hepatocellular carcinoma transforming from dysplastic nodule with background of non-B non-C chronic persistent hepatitis."Journal of Hepatology. 33. 857-858 (2000)

[Publications] Nomura H,Kudo M, et al.: "Laparoscopic splenopexy for adult wandering spleen : Sandwich method with two sheets of absorbable knitted mesh."Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. 10(5). 332-334 (2000)

[Publications] Kudo M: "Hepatocellular adenoma in type Ia glycogen storage disease."J Gastroenterol. 36. 65-66 (2001)

[Publications] Ding H,Kudo M, et al.: "Contrast-enhanced subtraction harmonic sonography for evaluating treatment response in patients with hepatpcellular carcinoma."AJR.. (in press). (2001)

[Publications] Kawasaki T,Kudo M, et al.: "Vascularity of advanced gastric carcinoma : evaluation by using power Doppler imaging."J Gastroenterol Hepatol 16 :.. 16(in press). (2001)

[Publications] Kim SR,Kudo M, et al.: "A case of disseminated extrahepatic carcinoma after US-guided biopsy and percutaneous ethanol injection therapy."Hepatology Research.. (in press). (2001)

[Publications] Kawasaki T,Kudo M, et al.: "A case of localized primary sclerosing cholangitis mimicking intrahepatic bile duct cancer."Hepatology Research.. (in press). (2001)

[Publications] Ding H,Kudo M, et al.: "Delection of tumor parenchymal flow in hepatocellular carcinoma : utility of intermittent harmonic imaging in the early arterial phase with dual display mode."Radiology.. (in press). (2001)

[Publications] Ding H,Kudo M, et al.: "Diagnosis of pancreatic islet cell tumor : value of intermittent harmonic imaging."JCU.. (in press). (2001)

[Publications] Kudo M: "Hepatic peribiliary cysts : clinically harmless disease with potential risk due to increase in size and number."J Gastroenterol.. (in press). (2001)

[Publications] Kudo M: "Cerebral vascular resistence in hepatic insufficiency."J Gastroenterol Hepatol.. (in press). (2001)

[Publications] Kudo M: "Blood flow characteristics and hepatocellular carcinoma."Oncology.. (in press). (2001)

[Publications] Kudo M: "Advances in diagnostic imaging of hepatocellular carcinoma.In "Hepatology in the 21st Century : Diagnosis and Therapy.""IASL, APASL, and JSH JOINT POST GRADUATE TEXTBOOK. 9 (2000)

[Publications] Kudo M: "Color Doppler observation of efferent blood flow in liver tumors.In Dynamic Study of Efferent Tumor Blood Fow"BRACCO, Italy, 2001 (in press). (2001)

工藤正俊近畿大学, 医学部・附属病院, 教授 (10298953)