2001 Fiscal Year Final Research Report Summary
Infrared Laser-Induced Giant Temperature-Jumps: Nonlinear Relaxation and Its Application to Dynamic Thermotherapy
| Project/Area Number |
10559016
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
広領域
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| Research Institution | Toyama University |
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Principal Investigator |
SUZUKI Honoh Toyama University, Chemistry, Associate Professor, 理学部, 助教授 (10216434)
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| Co-Investigator(Kenkyū-buntansha) |
NAGIRA Kazuhiko Dojin Laboratories, Research Division, Chief Researcher, 研究部研究課, 課長
INADA Yasuhiro Nagoya University, Chemistry, Research Associate, 大学院・理学研究科, 助手 (60242814)
FUNAHASHI Shigenobu Nagoya University, Chemistry, Professor, 大学院・理学研究科, 教授 (30022700)
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| Project Period (FY) |
1998 – 2000
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| Keywords | Infrared dyes / Temperature-jumps / Liposomes |
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| Research Abstract |
Giant temperature-jumps can be generated by utilizing a YAG laser and infrared-absorbing dyes as an efficient photo-thermal energy conversion system. In this study, the giant T-jumps have been applied to nonlinear relaxation phenomena in solution and liposomes that have potential use in drug delivery and cancer therapy.
1. Optical set-up and observation of laser-induced breakdown spectra: The lasers and optics purchased with this grant have been used to build a system for the observation of transient emission and absorption spectra. Laser-induced breakdown spectra (LIBS) at metal-air and metal-water interfaces have been observed.
2. Structure determination of metal complexes and observation of nonlinear relaxation in solution: Crystal structures of various metal complexes have been determined by X-ray diffraction. Giant T-jump experiments have been performed in thermochromic metal-complex solutions, and three distinct stages have been observed: thermal lensing, non-exponential thermochromism, and micro-bubble formation.
3. Development of the micro-flow-cell utilizing a liquid-core optical fiber: A novel micro-flow-cell has been developed to minimize scattering due to thermal lensing, which utilizes fluoro-polymer tubes to form a liquid-core optical fiber.
4. Application to liposomes: Infrared dyes have been doped in liposomes with various charges, sizes and distributions. Rupture of liposomes has been observed by detecting calcein fluorescence.
5. Future directions: Search for liposomes with optimal properties for medical and therapeutic use is being continued.
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