1999 Fiscal Year Final Research Report Summary
Relationship between infection and CD8 T cells - role of Tc2 cells
Project/Area Number |
10670791
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Dermatology
|
Research Institution | Okayama University |
Principal Investigator |
ARATA Jiro Okayama University Medical school, Professor, 医学部, 教授 (70033082)
|
Project Period (FY) |
1998 – 1999
|
Keywords | Atopic dermatitis / Infection / IgE / Tc1 cells / Tc2 cells |
Research Abstract |
The present study was performed to determine whether there is a relationship between infection and CD8 T cells. Tc2 cells have also been observed in CD8 T cells from patients infected with leprosy and human immunodeficiency virus (HIV). It remains unclear whether a dichotomy in Th1/Th2 or Tc1/Tc2 exists in atopic dermatitis. CD8+ memory/effector T cells circulating in atopic dermatitis (AD) patients were investigated. CD8+ CD45RO+ T cells were expressed type 2 cytokine (IL-4 and IL-13) expression in AD patients with high IgE levels. Spontaneous mRNA expression of IL-4 in blood CD8+ CD45RO+ T cells isolated from AD patients with high IgE levels was increased, as determined by reverse transcriptase polymerase chain reaction. Therefore, in AD patients with high IgE levels, type 2 cytokine (IL-4 and IL-13) expression is associated with IgE production, in both CD4+ CD45RO+ T cell and CD8+ CD45RO+ T cell subsets.
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Research Products
(4 results)